Chan CB, Kashemsant N: Regulation of insulin secretion by uncoupling protein. Biochem Soc Trans. 2006, 34 (Pt 5): 802-805.
Article
CAS
PubMed
Google Scholar
Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, Miroux B, Couplan E, Alves-Guerra MC, Goubern M, Surwit R, Bouillaud F, Richard D, Collins S, Ricquier D: Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet. 2000, 26 (4): 435-439. 10.1038/82565.
Article
CAS
PubMed
Google Scholar
De Souza CT, Araujo EP, Stoppiglia LF, Pauli JR, Ropelle E, Rocco SA, Marin RM, Franchini KG, Carvalheira JB, Saad MJ, Boschero AC, Carneiro EM, Velloso LA: Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action. FASEB J. 2007, 21 (4): 1153-1163. 10.1096/fj.06-7148com.
Article
CAS
PubMed
Google Scholar
Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB: Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 2001, 105 (6): 745-755. 10.1016/S0092-8674(01)00378-6.
Article
CAS
PubMed
Google Scholar
Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH: Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet. 1997, 15 (3): 269-272. 10.1038/ng0397-269.
Article
CAS
PubMed
Google Scholar
Solanes G, Vidal-Puig A, Grujic D, Flier JS, Lowell BB: The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. J Biol Chem. 1997, 272 (41): 25433-25436. 10.1074/jbc.272.41.25433.
Article
CAS
PubMed
Google Scholar
Saunders CL, Chiodini BD, Sham P, Lewis CM, Abkevich V, Adeyemo AA, de Andrade M, Arya R, Berenson GS, Blangero J, Boehnke M, Borecki IB, Chagnon YC, Chen W, Comuzzie AG, Deng HW, Duggirala R, Feitosa MF, Froguel P, Hanson RL, Hebebrand J, Huezo-Dias P, Kissebah AH, Li W, Luke A, Martin LJ, Nash M, Ohman M, Palmer LJ, Peltonen L, Perola M, Price RA, Redline S, Srinivasan SR, Stern MP, Stone S, Stringham H, Turner S, Wijmenga C, A Collier D: Meta-Analysis of Genome-wide Linkage Studies in BMI and Obesity. Obesity (Silver Spring). 2007, 15 (9): 2263-2275. 10.1038/oby.2007.269.
Article
Google Scholar
Walder K, Norman RA, Hanson RL, Schrauwen P, Neverova M, Jenkinson CP, Easlick J, Warden CH, Pecqueur C, Raimbault S, Ricquier D, Silver MH, Shuldiner AR, Solanes G, Lowell BB, Chung WK, Leibel RL, Pratley R, Ravussin E: Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians. Hum Mol Genet. 1998, 7 (9): 1431-1435. 10.1093/hmg/7.9.1431.
Article
CAS
PubMed
Google Scholar
Kubota T, Mori H, Tamori Y, Okazawa H, Fukuda T, Miki M, Ito C, Fleury C, Bouillaud F, Kasuga M: Molecular screening of uncoupling protein 2 gene in patients with noninsulin-dependent diabetes mellitus or obesity. J Clin Endocrinol Metab. 1998, 83 (8): 2800-2804. 10.1210/jc.83.8.2800.
CAS
PubMed
Google Scholar
Cassell PG, Neverova M, Janmohamed S, Uwakwe N, Qureshi A, McCarthy MI, Saker PJ, Albon L, Kopelman P, Noonan K, Easlick J, Ramachandran A, Snehalatha C, Pecqueur C, Ricquier D, Warden C, Hitman GA: An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes. Diabetologia. 1999, 42 (6): 688-692. 10.1007/s001250051216.
Article
CAS
PubMed
Google Scholar
Ukkola O, Tremblay A, Sun G, Chagnon YC, Bouchard C: Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding. Eur J Clin Nutr. 2001, 55 (11): 1008-1015. 10.1038/sj.ejcn.1601261.
Article
CAS
PubMed
Google Scholar
Rosmond R, Bouchard C, Bjorntorp P: Lack of association between the uncoupling protein-2 Ala55Val gene polymorphism and phenotypic features of the Metabolic Syndrome. Biochim Biophys Acta. 2002, 1588 (2): 103-105.
Article
CAS
PubMed
Google Scholar
Wang H, Chu WS, Lu T, Hasstedt SJ, Kern PA, Elbein SC: Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. Am J Physiol Endocrinol Metab. 2004, 286 (1): E1-7. 10.1152/ajpendo.00231.2003.
Article
CAS
PubMed
Google Scholar
Krempler F, Esterbauer H, Weitgasser R, Ebenbichler C, Patsch JR, Miller K, Xie M, Linnemayr V, Oberkofler H, Patsch W: A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans. Diabetes. 2002, 51 (11): 3331-3335. 10.2337/diabetes.51.11.3331.
Article
CAS
PubMed
Google Scholar
Sesti G, Cardellini M, Marini MA, Frontoni S, D'Adamo M, Del Guerra S, Lauro D, De Nicolais P, Sbraccia P, Del Prato S, Gambardella S, Federici M, Marchetti P, Lauro R: A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. Diabetes. 2003, 52 (5): 1280-1283. 10.2337/diabetes.52.5.1280.
Article
CAS
PubMed
Google Scholar
Le Fur S, Le Stunff C, Dos Santos C, Bougneres P: The common -866 g/a polymorphism in the promoter of uncoupling protein 2 is associated with increased carbohydrate and decreased lipid oxidation in juvenile obesity. Diabetes. 2004, 53 (1): 235-239. 10.2337/diabetes.53.1.235.
Article
CAS
PubMed
Google Scholar
Esterbauer H, Schneitler C, Oberkofler H, Ebenbichler C, Paulweber B, Sandhofer F, Ladurner G, Hell E, Strosberg AD, Patsch JR, Krempler F, Patsch W: A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet. 2001, 28 (2): 178-183. 10.1038/88911.
Article
CAS
PubMed
Google Scholar
Dhamrait SS, Stephens JW, Cooper JA, Acharya J, Mani AR, Moore K, Miller GJ, Humphries SE, Hurel SJ, Montgomery HE: Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2. Eur Heart J. 2004, 25 (6): 468-475. 10.1016/j.ehj.2004.01.007.
Article
CAS
PubMed
Google Scholar
Dalgaard LT, Pedersen O: Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes. Diabetologia. 2001, 44 (8): 946-965. 10.1007/s001250100596.
Article
CAS
PubMed
Google Scholar
Kovacs P, Ma L, Hanson RL, Franks P, Stumvoll M, Bogardus C, Baier LJ: Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians. Diabetologia. 2005, 48 (11): 2292-2295. 10.1007/s00125-005-1934-9.
Article
CAS
PubMed
Google Scholar
Oberkofler H, Iglseder B, Klein K, Unger J, Haltmayer M, Krempler F, Paulweber B, Patsch W: Associations of the UCP2 gene locus with asymptomatic carotid atherosclerosis in middle-aged women. Arterioscler Thromb Vasc Biol. 2005, 25 (3): 604-610. 10.1161/01.ATV.0000153141.42033.22.
Article
CAS
PubMed
Google Scholar
Argiles JM, Busquets S, Lopez-Soriano FJ: The role of uncoupling proteins in pathophysiological states. Biochem Biophys Res Commun. 2002, 293 (4): 1145-1152. 10.1016/S0006-291X(02)00355-8.
Article
PubMed
Google Scholar
Schrauwen P, Hesselink M: UCP2 and UCP3 in muscle controlling body metabolism. J Exp Biol. 2002, 205 (Pt 15): 2275-2285.
CAS
PubMed
Google Scholar
Nabben M, Hoeks J: Mitochondrial uncoupling protein 3 and its role in cardiac- and skeletal muscle metabolism. Physiol Behav. 2008, 94 (2): 259-269. 10.1016/j.physbeh.2007.11.039.
Article
CAS
PubMed
Google Scholar
Schrauwen P, Xia J, Walder K, Snitker S, Ravussin E: A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians. Int J Obes Relat Metab Disord. 1999, 23 (12): 1242-1245. 10.1038/sj.ijo.0801057.
Article
CAS
PubMed
Google Scholar
Schrauwen P, Xia J, Bogardus C, Pratley RE, Ravussin E: Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians. Diabetes. 1999, 48 (1): 146-149. 10.2337/diabetes.48.1.146.
Article
CAS
PubMed
Google Scholar
Herrmann SM, Wang JG, Staessen JA, Kertmen E, Schmidt-Petersen K, Zidek W, Paul M, Brand E: Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio. J Mol Med. 2003, 81 (5): 327-332.
PubMed
Google Scholar
Meirhaeghe A, Amouyel P, Helbecque N, Cottel D, Otabe S, Froguel P, Vasseur F: An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort. Diabetologia. 2000, 43 (11): 1424-1428. 10.1007/s001250051549.
Article
CAS
PubMed
Google Scholar
Otabe S, Clement K, Dina C, Pelloux V, Guy-Grand B, Froguel P, Vasseur F: A genetic variation in the 5' flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity. Diabetologia. 2000, 43 (2): 245-249. 10.1007/s001250050037.
Article
CAS
PubMed
Google Scholar
Liu YJ, Liu PY, Long J, Lu Y, Elze L, Recker RR, Deng HW: Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families. Physiol Genomics. 2005, 22 (2): 197-203. 10.1152/physiolgenomics.00031.2005.
Article
CAS
PubMed
Google Scholar
Halsall DJ, Luan J, Saker P, Huxtable S, Farooqi IS, Keogh J, Wareham NJ, O'Rahilly S: Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population. Int J Obes Relat Metab Disord. 2001, 25 (4): 472-477. 10.1038/sj.ijo.0801584.
Article
CAS
PubMed
Google Scholar
Hamada T, Kotani K, Fujiwara S, Sano Y, Domichi M, Tsuzaki K, Sakane N: The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population. Metabolism. 2008, 57 (3): 410-415. 10.1016/j.metabol.2007.10.019.
Article
CAS
PubMed
Google Scholar
van Abeelen AF, de Krom M, Hendriks J, Grobbee DE, Adan RA, Schouw van der YT: Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes. Eur J Endocrinol. 2008, 158 (5): 669-676. 10.1530/EJE-07-0834.
Article
CAS
PubMed
Google Scholar
Cha MH, Shin HD, Kim KS, Lee BH, Yoon Y: The effects of uncoupling protein 3 haplotypes on obesity phenotypes and very low-energy diet-induced changes among overweight Korean female subjects. Metabolism. 2006, 55 (5): 578-586. 10.1016/j.metabol.2005.11.012.
Article
CAS
PubMed
Google Scholar
Dalgaard LT, Sorensen TI, Drivsholm T, Borch-Johnsen K, Andersen T, Hansen T, Pedersen O: A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population. J Clin Endocrinol Metab. 2001, 86 (3): 1398-1402. 10.1210/jc.86.3.1398.
CAS
PubMed
Google Scholar
de Luis DA, Aller R, Izaola O, Gonzalez Sagrado M, Conde R, Perez Castrillon JL: Lack of association of -55CT polymorphism of UCP3 gene with fat distribution in obese patients. Ann Nutr Metab. 2007, 51 (4): 374-378. 10.1159/000107685.
Article
CAS
PubMed
Google Scholar
Uusitupa M, Louheranta A, Lindström J, Valle T, Sundvall J, Eriksson J, Tuomilehto J: The Finnish Diabetes Prevention Study. Br J Nutr. 2000, 83 (Suppl 1): S137-42.
CAS
PubMed
Google Scholar
Eriksson J, Lindström J, Valle T, Aunola S, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Lauhkonen M, Lehto P, Lehtonen A, Louheranta A, Mannelin M, Martikkala V, Rastas M, Sundvall J, Turpeinen A, Viljanen T, Uusitupa M, Tuomilehto J: Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme. Diabetologia. 1999, 42 (7): 793-801. 10.1007/s001250051229.
Article
CAS
PubMed
Google Scholar
Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M, Finnish Diabetes Prevention Study Group: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001, 344 (18): 1343-1350. 10.1056/NEJM200105033441801.
Article
CAS
PubMed
Google Scholar
Albareda M, Rodriguez-Espinosa J, Murugo M, de Leiva A, Corcoy R: Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test. Diabetologia. 2000, 43 (12): 1507-1511. 10.1007/s001250051561.
Article
CAS
PubMed
Google Scholar
Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972, 18 (6): 499-502.
CAS
PubMed
Google Scholar
de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D: Efficiency and power in genetic association studies. Nat Genet. 2005, 37 (11): 1217-1223. 10.1038/ng1669.
Article
CAS
PubMed
Google Scholar
Cassell PG, Saker PJ, Huxtable SJ, Kousta E, Jackson AE, Hattersley AT, Frayling TM, Walker M, Kopelman PG, Ramachandran A, Snehelatha C, Hitman GA, McCarthy MI: Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin. Diabetologia. 2000, 43 (12): 1558-1564. 10.1007/s001250051569.
Article
CAS
PubMed
Google Scholar
Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005, 21 (2): 263-265. 10.1093/bioinformatics/bth457.
Article
CAS
PubMed
Google Scholar
Tregouet DA, Escolano S, Tiret L, Mallet A, Golmard JL: A new algorithm for haplotype-based association analysis: the Stochastic-EM algorithm. Ann Hum Genet. 2004, 68 (Pt 2): 165-177. 10.1046/j.1529-8817.2003.00085.x.
Article
CAS
PubMed
Google Scholar
Storey JD, Tibshirani R: Statistical significance for genomewide studies. Proc Natl Acad Sci USA. 2003, 100 (16): 9440-9445. 10.1073/pnas.1530509100.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gable DR, Stephens JW, Cooper JA, Miller GJ, Humphries SE: Variation in the UCP2-UCP3 gene cluster predicts the development of type 2 diabetes in healthy middle-aged men. Diabetes. 2006, 55 (5): 1504-1511. 10.2337/db05-1645.
Article
CAS
PubMed
Google Scholar
Damcott CM, Feingold E, Moffett SP, Barmada MM, Marshall JA, Hamman RF, Ferrell RE: Genetic variation in uncoupling protein 3 is associated with dietary intake and body composition in females. Metabolism. 2004, 53 (4): 458-464. 10.1016/j.metabol.2003.11.019.
Article
CAS
PubMed
Google Scholar
Despres JP, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, Rodes-Cabau J, Bertrand OF, Poirier P: Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol. 2008, 28 (6): 1039-1049. 10.1161/ATVBAHA.107.159228.
Article
CAS
PubMed
Google Scholar
Lee CM, Huxley RR, Wildman RP, Woodward M: Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis. J Clin Epidemiol. 2008, 61 (7): 646-653. 10.1016/j.jclinepi.2007.08.012.
Article
PubMed
Google Scholar
Cheurfa N, Dubois-Laforgue D, Ferrarezi DA, Reis AF, Brenner GM, Bouche C, Le Feuvre C, Fumeron F, Timsit J, Marre M, Velho G: The common -866G>A variant in the promoter of UCP2 is associated with decreased risk of coronary artery disease in type 2 diabetic men. Diabetes. 2008, 57 (4): 1063-1068. 10.2337/db07-1292.
Article
CAS
PubMed
Google Scholar
Bulotta A, Ludovico O, Coco A, Di Paola R, Quattrone A, Carella M, Pellegrini F, Prudente S, Trischitta V: The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy. J Clin Endocrinol Metab. 2005, 90 (2): 1176-1180. 10.1210/jc.2004-1072.
Article
CAS
PubMed
Google Scholar
Sasahara M, Nishi M, Kawashima H, Ueda K, Sakagashira S, Furuta H, Matsumoto E, Hanabusa T, Sasaki H, Nanjo K: Uncoupling protein 2 promoter polymorphism -866G/A affects its expression in beta-cells and modulates clinical profiles of Japanese type 2 diabetic patients. Diabetes. 2004, 53 (2): 482-485. 10.2337/diabetes.53.2.482.
Article
CAS
PubMed
Google Scholar
D'Adamo M, Perego L, Cardellini M, Marini MA, Frontoni S, Andreozzi F, Sciacqua A, Lauro D, Sbraccia P, Federici M, Paganelli M, Pontiroli AE, Lauro R, Perticone F, Folli F, Sesti G: The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes. Diabetes. 2004, 53 (7): 1905-1910. 10.2337/diabetes.53.7.1905.
Article
PubMed
Google Scholar
Cha MH, Kim IC, Kim KS, Kang BK, Choi SM, Yoon Y: Association of UCP2 and UCP3 gene polymorphisms with serum high-density lipoprotein cholesterol among Korean women. Metabolism. 2007, 56 (6): 806-813. 10.1016/j.metabol.2007.01.023.
Article
CAS
PubMed
Google Scholar
Reis AF, Dubois-Laforgue D, Bellanne-Chantelot C, Timsit J, Velho G: A polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetes. Mol Genet Metab. 2004, 82 (4): 339-344. 10.1016/j.ymgme.2004.06.008.
Article
CAS
PubMed
Google Scholar
O'Rahilly S: Uncoupling protein 2: Adiposity angel and diabetes devil?. Nat Med. 2001, 7 (7): 770-772. 10.1038/89877.
Article
PubMed
Google Scholar
Bezaire V, Seifert EL, Harper ME: Uncoupling protein-3: clues in an ongoing mitochondrial mystery. FASEB J. 2007, 21 (2): 312-324. 10.1096/fj.06-6966rev.
Article
CAS
PubMed
Google Scholar