Table 5 Associations of UCP2 and UCP3 gene variants with waist-to-hip ratio (WHR) and serum lipid concentrations in previous studies
| Â | Ref. | Subjects (number, ethnicity) | Variant | Risk allele | Association |
|---|---|---|---|---|---|
WHR | [43] | 710, South Indian 450, Caucasoid | UCP3: rs1800849 | T | Higher WHR |
| Â | [27] | 162, Caucasoid | UCP3: rs1800849 | T | Higher WHR |
| Â | [34] | 460, Asian | UCP3: haplotype including rs1800849 | C in haplotype CGTACC | Higher WHR |
Lipids | [28] | 1175, Caucasoid | UCP3: rs1800849 | T | Higher total and LDL-cholesterol conc. |
| Â | [13] | 796, several | UCP2: rs659366 UCP2: rs660339 UCP2: Del/Ins | Heterozygous genotype combination GTI/ATD | Higher triglyceride concentration |
| Â | [56] | 681, Caucasoid | UCP2: rs659366 | A | Higher triglyceride, total and LDL-cholesterol conc. |
| Â | [55] | 658, Asian | UCP2: rs659366 UCP2: rs660339 | A T | Lower HDL-cholesterol concentration |
| Â | [32] | 282, Japanese | UCP3: rs1800849 | C | Lower HDL-cholesterol concentration |