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Table 4 Frequencies and associations of the major haplotypes (frequency ≥ 0.05) of three haploblocks in the UCP2-UCP3 gene region

From: Variation in the UCP2 and UCP3genes associates with abdominal obesity and serum lipids: The Finnish Diabetes Prevention Study

Haploblock

Marker

Frequency

Association

Block 1

DelIns

rs660339

    
 

Del

C

  

0.519a

NS

 

Ins

T

  

0.300

NS

 

Del

T

  

0.177

NS

Block 2

rs659366

rs653529

rs15763

rs1726745

  
 

G

A

G

A

0.359a

NS

 

G

A

G

G

0.203

NS

 

A

G

A

G

0.202

↓ WHR, p = 0.050b

 

A

G

G

G

0.175

NS

Block 3

rs3781907

rs11235972

rs1800849

   
 

A

G

C

 

0.584a

NS

 

G

A

T

 

0.288

↑ cholesterol, p = 0.006c

↑ LDL, p = 0.024c

 

A

A

T

 

0.084

↓ΔLDL, p = 0.037c

  1. a The most frequent haplotype is the reference, with which the others are compared
  2. b Adjusted for age and gender
  3. c Adjusted for age, gender and BMI
  4. ↑, higher in comparison with the reference haplotype; ↓, lower in comparison with the reference haplotype