Willcocks LC, Lyons PA, Rees AJ, Smith KGC: Pathogenesis of ANCA-associated systemic vasculitis: genetic variation and infections. Arthritis Research & Therapy. 2009,
Google Scholar
Knight A, Sandin S, Askling J: Risks and relative risks of Wegener's granulomatosis among close relatives of patients with the disease. Arthritis and Rheumatism. 2008, 58 (1): 302-307. 10.1002/art.23157.
Article
PubMed
Google Scholar
Jagiello P, Gross WL, Epplen JT: Complex genetics of Wegener granulomatosis. Autoimmunity Reviews. 2005, 4 (1): 42-47. 10.1016/j.autrev.2004.06.003.
Article
CAS
PubMed
Google Scholar
Heckmann M, Holle JU, Arning L, Knaup S, Hellmich B, Nothnagel M, Jagiello P, Gross WL, Epplen JT, Wieczorek S: The Wegener's granulomatosis quantitative trait locus on chromosome 6p21.3 as characterised by tagSNP genotyping. Annals of the Rheumatic Diseases. 2008, 67 (7): 972-979. 10.1136/ard.2007.077693.
Article
CAS
PubMed
Google Scholar
Brand O, Gough S, Heward J: HLA, CTLA-4 and PTPN22: the shared genetic master-key to autoimmunity?. Expert Reviews in Molecular Medicine. 2005, 7 (23): 1-15. 10.1017/S1462399405009981.
Article
PubMed
Google Scholar
Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, et al: Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics. 2007, 39 (7): 857-864. 10.1038/ng2068.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hafler JP, Maier LM, Cooper JD, Plagnol V, Hinks A, Simmonds MJ, Stevens HE, Walker NM, Healy B, Howson JM, et al: CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity. 2009, 10 (1): 5-10. 10.1038/gene.2008.82.
Article
CAS
PubMed
Google Scholar
Carr EJ, Clatworthy MR, Lowe CE, Todd JA, Wong A, Vyse TJ, Kamesh L, Watts RA, Lyons PA, Smith KGC: Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis. BMC Medical Genetics. 2009, 10: 22-10.1186/1471-2350-10-22.
Article
PubMed
PubMed Central
Google Scholar
Giscombe R, Wang X, Huang D, Lefvert AK: Coding sequence 1 and promoter single nucleotide polymorphisms in the CTLA-4 gene in Wegener's granulomatosis. The Journal of Rheumatology. 2002, 29 (5): 950-953.
CAS
PubMed
Google Scholar
Slot MC, Sokolowska MG, Savelkouls KG, Janssen RG, Damoiseaux JG, Cohen Tervaert JW: Immunoregulatory gene polymorphisms are associated with ANCA-related vasculitis. Clinical Immunology (Orlando, Fla). 2008, 128 (1): 39-45. 10.1016/j.clim.2008.03.506.
Article
CAS
Google Scholar
Jagiello P, Aries P, Arning L, Wagenleiter SE, Csernok E, Hellmich B, Gross WL, Epplen JT: The PTPN22 620W allele is a risk factor for Wegener's granulomatosis. Arthritis and Rheumatism. 2005, 52 (12): 4039-4043. 10.1002/art.21487.
Article
CAS
PubMed
Google Scholar
Wieczorek S, Hoffjan S, Chan A, Rey L, Harper L, Fricke H, Holle JU, Gross WL, Epplen JT, Lamprecht P: Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients. Genes and Immunity. 2009, 10 (6): 591-5. 10.1038/gene.2009.44.
Article
CAS
PubMed
Google Scholar
Steiner K, Moosig F, Csernok E, Selleng K, Gross WL, Fleischer B, Bröker BM: Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis. Clinical and Experimental Immunology. 2001, 126 (1): 143-150. 10.1046/j.1365-2249.2001.01575.x.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhou Y, Huang D, Paris PL, Sauter CS, Prock KA, Hoffman GS: An analysis of CTLA-4 and proinflammatory cytokine genes in Wegener's granulomatosis. Arthritis and Rheumatism. 2004, 50 (8): 2645-2650. 10.1002/art.20385.
Article
CAS
PubMed
Google Scholar
Spriewald BM, Witzke O, Wassmuth R, Wenzel RR, Arnold ML, Philipp T, Kalden JR: Distinct tumour necrosis factor alpha, interferon gamma, interleukin 10, and cytotoxic T cell antigen 4 gene polymorphisms in disease occurrence and end stage renal disease in Wegener's granulomatosis. Annals of the Rheumatic Diseases. 2005, 64 (3): 457-461. 10.1136/ard.2004.025809.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, Hagen EC, Hoffman GS, Hunder GG, Kallenberg CG: Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis and Rheumatism. 1994, 37 (2): 187-192. 10.1002/art.1780370206.
Article
CAS
PubMed
Google Scholar
Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007, 447 (7145): 661-678. 10.1038/nature05911.
Article
Google Scholar
Gonzalez JR, Armengol L, Sole X, Guino E, Mercader JM, Estivill X, Moreno V: SNPassoc: an R package to perform whole genome association studies. Bioinformatics. 2007, 23 (5): 644-645. 10.1093/bioinformatics/btm025.
Article
PubMed
Google Scholar
Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, Thompson CB, Griesser H, Mak TW: Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (New York, NY). 1995, 270 (5238): 985-988.
Article
CAS
Google Scholar
Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH: Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995, 3 (5): 541-547. 10.1016/1074-7613(95)90125-6.
Article
CAS
PubMed
Google Scholar
Stamper CC, Zhang Y, Tobin JF, Erbe DV, Ikemizu S, Davis SJ, Stahl ML, Seehra J, Somers WS, Mosyak L: Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature. 2001, 410 (6828): 608-611. 10.1038/35069118.
Article
CAS
PubMed
Google Scholar
Zhang X, Schwartz JC, Almo SC, Nathenson SG: Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling. Proceedings of the National Academy of Sciences of the United States of America. 2003, 100 (5): 2586-2591. 10.1073/pnas.252771499.
Article
CAS
PubMed
PubMed Central
Google Scholar
Oaks MK, Hallett KM, Penwell RT, Stauber EC, Warren SJ, Tector AJ: A native soluble form of CTLA-4. Cellular Immunology. 2000, 201 (2): 144-153. 10.1006/cimm.2000.1649.
Article
CAS
PubMed
Google Scholar
Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S: CTLA-4 control over Foxp3+ regulatory T cell function. Science. 2008, 322 (5899): 271-275. 10.1126/science.1160062.
Article
CAS
PubMed
Google Scholar
Rudd CE: The reverse stop-signal model for CTLA4 function. Nature Reviews Immunology. 2008, 8 (2): 153-160. 10.1038/nri2253.
Article
CAS
PubMed
Google Scholar
Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, et al: Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature. 2003, 423 (6939): 506-511. 10.1038/nature01621.
Article
CAS
PubMed
Google Scholar
Kavvoura FK, Akamizu T, Awata T, Ban Y, Chistiakov DA, Frydecka I, Ghaderi A, Gough SC, Hiromatsu Y, Ploski R, et al: Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis. The Journal of Clinical Endocrinology and Metabolism. 2007, 92 (8): 3162-3170. 10.1210/jc.2007-0147.
Article
CAS
PubMed
Google Scholar
Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, et al: Shared and distinct genetic variants in type 1 diabetes and celiac disease. The New England Journal of Medicine. 2008, 359 (26): 2767-2777. 10.1056/NEJMoa0807917.
Article
CAS
PubMed
PubMed Central
Google Scholar
Daha NA, Kurreeman FA, Marques RB, Stoeken-Rijsbergen G, Verduijn W, Huizinga TW, Toes RE: Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis. Arthritis and Rheumatism. 2009, 60 (5): 1255-1260. 10.1002/art.24503.
Article
PubMed
Google Scholar
Purohit S, Podolsky R, Collins C, Zheng W, Schatz D, Muir A, Hopkins D, Huang Y, She J: Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes. Journal of Autoimmune Diseases. 2005, 2: 8-10.1186/1740-2557-2-8.
Article
PubMed
PubMed Central
Google Scholar
Wang X, Zhao X, Giscombe R, Lefvert A: A CTLA-4 gene polymorphism at position -318 in the promoter region affects the expression of protein. Genes and Immunity. 2002, 3 (4): 233-234. 10.1038/sj.gene.6363869.
Article
PubMed
Google Scholar
Maier LM, Anderson DE, De Jager PL, Wicker LS, Hafler D: Allelic variant in CTLA4 alters T cell phosphorylation patterns. Proceedings of the National Academy of Sciences of the United States of America. 2007, 104 (47): 18607-18612. 10.1073/pnas.0706409104.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA: Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature. 2007, 445 (7130): 931-935. 10.1038/nature05478.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li QJ, Chau J, Ebert PJ, Sylvester G, Min H, Liu G, Braich R, Manoharan M, Soutschek J, Skare P, et al: miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell. 2007, 129 (1): 147-161. 10.1016/j.cell.2007.03.008.
Article
CAS
PubMed
Google Scholar
Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F, et al: Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nature Genetics. 2005, 37 (12): 1317-1319. 10.1038/ng1673.
Article
CAS
PubMed
Google Scholar
Arechiga AF, Habib T, He Y, Zhang X, Zhang ZY, Funk A, Buckner JH: Cutting edge: The PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. Journal of Immunology (Baltimore, Md: 1950). 2009, 182 (6): 3343-3347.
Article
CAS
Google Scholar
Hasegawa K, Martin F, Huang G, Tumas D, Diehl L, Chan AC: PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science (New York, NY). 2004, 303 (5658): 685-689.
Article
CAS
Google Scholar
Vang T, Miletic AV, Arimura Y, Tautz L, Rickert RC, Mustelin T: Protein tyrosine phosphatases in autoimmunity. Annual Review of Immunology. 2008, 26: 29-55. 10.1146/annurev.immunol.26.021607.090418.
Article
CAS
PubMed
Google Scholar
Barrett J, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, et al: Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nature Genetics. 2008, 40 (8): 955-962. 10.1038/ng.175.
Article
CAS
PubMed
PubMed Central
Google Scholar
Criswell LA, Pfeiffer KA, Lum RF, Gonzales B, Novitzke J, Kern M, Moser KL, Begovich AB, Carlton VE, Li W, et al: Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. American Journal of Human Genetics. 2005, 76 (4): 561-571. 10.1086/429096.
Article
CAS
PubMed
PubMed Central
Google Scholar
Brand OJ, Lowe CE, Heward JM, Franklyn JA, Cooper JD, Todd JA, Gough SC: Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clin Endocrinol (Oxf). 2007, 66 (4): 508-512.
CAS
Google Scholar
Lowe CE, Cooper JD, Brusko T, Walker NM, Smyth DJ, Bailey R, Bourget K, Plagnol V, Field S, Atkinson M, et al: Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nature Genetics. 2007, 39 (9): 1074-1082. 10.1038/ng2102.
Article
CAS
PubMed
Google Scholar
Tait KF, Marshall T, Berman J, Carr-Smith J, Rowe B, Todd JA, Bain SC, Barnett AH, Gough SC: Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository. Diabetic Medicine: A Journal of the British Diabetic Association. 2004, 21 (4): 358-362.
Article
CAS
Google Scholar