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Table 2 Genotype and allele associations for CTLA4 rs3087243 and PTPN22 rs2476601 in AAV

From: Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis

 

Controls

AAV cases

 
 

n

Frequency

n

Frequency

P value

CTLA4 rs3087243

     

GG

2726

0.30

198

0.34

 

GA

4453

0.49

282

0.49

 

AA

1861

0.21

95

0.17

0.02*

G

9905

0.55

678

0.59

 

A

8175

0.45

472

0.41

6.4 × 10-3 ** §

PTPN22 rs2476601

     

GG

6044

0.82

471

0.75

 

GA

1298

0.18

146

0.23

 

AA

70

0.01

9

0.01

5.2 × 10-4 *

G

13386

0.90

1088

0.87

 

A

1438

0.10

164

0.13

1.4 × 10-4 **§§

  1. * P value calculated by χ2 test on 3 × 2 contingency table
  2. ** P value calculated by χ2 test on 2 × 2 contingency table
  3. § Odds ratio (OR) for minor allele (A) = 0.84
  4. §§ OR for minor allele = 1.40
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BMC Medical Genetics

ISSN: 1471-2350

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