Balen AH, Conway GS, Kaltsas G, Techatrasak K, Manning PJ, West C, Jacobs HS. Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod. 1995;10:2107–11.
Article
CAS
PubMed
Google Scholar
Wijeyaratne CN, Udayangani SAD, Balen AH. Ethnic-specific polycystic ovary syndrome: epidemiology, significance and implications. Expert Rev Endocrinol Metab. 2013;8(1):71–9.
Article
CAS
PubMed
Google Scholar
Studen KB, Pfeifer M. Cardiometabolic risk in polycystic ovary syndrome. Endocr Connect. 2018;7(7):R238–51.
Article
CAS
Google Scholar
Apridonidze T, Essah PA, Iurno MJ, Nestler JE. Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005;90:1929–35.
Article
CAS
PubMed
Google Scholar
Barber TM, Bennett AJ, Groves CJ, Sovio U, Ruokonen A, Martikainen H, Pouta A, Hartikainen AL, Elliott P, Lindgren CM, Freathy RM, Koch K, Ouwehand WH, Karpe F, Conway GS, Wass JA, Järvelin MR, Franks S, McCarthy MI. Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome. Diabetologia. 2008;51(7):1153–8.
Article
CAS
PubMed
Google Scholar
Alexander CJ, Tangchitnob E, Lepor NE. Polycystic ovary syndrome: a major unrecognized cardiovascular risk factor in women. Rev Cardiovasc Med. 2009;10:83–90.
PubMed
Google Scholar
Diamanti-Kandarakis E, Piperi C, Spina J, Argyrakopoulou G, Papanastasiou L, Bergiele A, Panidis D. Polycystic ovary syndrome: the influence of environmental and genetic factors. Hormones (Athens) Rev. 2006;5(1):17–34.
Article
Google Scholar
Diamanti-Kandarakis E, Christakou C, Kandarakis H, Alexandraki KI. Early onset adiposity: a pathway to polycystic ovary syndrome in adolescents? Hormones (Athens). 2007;6(3):210–7.
Google Scholar
Diamanti-Kandarakis E, Christakou C, Palioura E, Kandaraki E, Livadas S. Does polycystic ovary syndrome start in childhood? Pediatr Endocrinol Rev. 2008;5(4):904–11.
PubMed
Google Scholar
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316(5826):889–94.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wehr E, Schweighofer N, Moller R, Giuliani A, Pieber TR, Obermayer-Pietsch B. Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome. Metabolism. 2010;59:575–80.
Article
CAS
PubMed
Google Scholar
De Luis DA, Aller R, Conde R, Izaola O, De La Fuente B, Sagrado MG. Relation of the rs9939609 gene variant in fto with metabolic syndrome in obese female patients. J Diabetes Complicat. 2013;27(4):346–50.
Article
Google Scholar
Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. 2001;411(6837):613–7.
Article
CAS
PubMed
Google Scholar
Ojeda SR, Urbanski HF, Ahmed CE. The onset of female puberty: studies in the rat. Recent Prog Horm Res. 1986;42:385–442.
CAS
PubMed
Google Scholar
Luan X, Zhou Y, Wang W, Yu H, Li P, Gan X, Wei D, Xiao J. Association study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girls. Eur J Endocrinol. 2007;157(1):113–8.
Article
CAS
PubMed
Google Scholar
Levine JE. In: Encyclopedia of hormones. Henry H, Norman A, editors. Gonadotropin-releasing hormone (GnRH); 2003. p. 157–65.
Google Scholar
Sam S. Obesity and polycystic ovary syndrome. Obes Manag. 2007;3(2):69–73.
Article
PubMed
PubMed Central
Google Scholar
Barber TM, Franks S. The link between polycystic ovary syndrome and both type 1 and type 2 diabetes mellitus. Women Health. 2012;8(2):147–54.
Article
CAS
Google Scholar
Yan Q, Hong J, Gu W, Zhang Y, Liu Q, Su Y, Zhang Y, Li X, Cui B, Ning G. Association of the common rs9939609 variant of FTO gene with polycystic ovary syndrome in Chinese women. Endocrine. 2009;36(3):377–82.
Article
CAS
PubMed
Google Scholar
Osman HG, El-Refaeey AAA, El-Sokkary AMA, El-Sokkary MMA, El-Saeed RA. A study on fat mass and obesity associated (FTO) gene rs9939609 variant in Egyptian women with polycystic ovarian syndrome. Aust J Basic Appl Sci. 2014;8(13):98–104.
Google Scholar
Al-Tu'ma FJ, HadiFarhan N, Al-Safi WG. Association between fat mass and obesity Geners9939609 polymorphism with PCOS women in Iraqi population. Ijppr Human. 2015;5(1):62–72.
CAS
Google Scholar
Mehta J, Kamdar V, Dumesic D. Phenotypic expression of polycystic ovary syndrome in south Asian women. Obstet Gynecol Surv. 2013;68(3):228–34.
Article
PubMed
Google Scholar
Attaoua R, Ait El Mkadem S, Radian S, Fica S, Hanzu F, Albu A, Gheorghiu M, Coculescu M, Grigorescu F. FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome. Biochem Biophys Res Commun. 2008;373:230–4.
Article
CAS
PubMed
Google Scholar
Song DK, Lee H, Oh JY, Hong YS, Sung YA. FTO gene variants are associated with PCOS susceptibility and hyperandrogenemia in young Korean women. Diabetes Metab J. 2014;38(4):302–10.
Article
PubMed
PubMed Central
Google Scholar
Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19–25.
Google Scholar
Schlesselman J. Case-control studies: design, conduct, analysis, vol. 354. New York: Oxford University Press; 1982.
Google Scholar
Umayal B, Jayakody SN, Chandrasekharan NV, Wijesundera WS, Wijeyaratne CN. Polycystic ovary syndrome (PCOS) and kisspeptin - a Sri Lankan study. J Postgrad Med. 2019;65(1):18–23.
Article
CAS
PubMed
PubMed Central
Google Scholar
Branavan U, Muneeswaran K, Wijesundera S, Jayakody S, Chandrasekharan V, Wijeyaratne C. Identification of selected genetic polymorphisms in polycystic ovary syndrome in Sri Lankan women using low cost genotyping techniques. PLoS One. 2018;13(12):e0209830 https://doi.org/10.1371/journal.pone.0209830.
Article
PubMed
PubMed Central
Google Scholar
Branavan U, Muneeswaran K, Wijesundera WSS, Senanayake A, Chandrasekharan NV, Wijeyaratne CN. Association of Kiss1 and GPR54 gene polymorphisms with polycystic ovary syndrome among Sri Lankan women. Biomed Res Int. 2019; https://doi.org/10.1155/2019/6235680.
Article
CAS
Google Scholar
Valkenburg O, Uitterlinden AG, Piersma D, Hofman A, Themmen AP, de Jong FH, Fauser BC, Laven JS. Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome. Hum Reprod. 2009;24:2014–22.
Article
CAS
PubMed
Google Scholar
Chen ZJ, Zhao H, He L, Shi Y, Qin Y, Shi Y, Li Z, You L, Zhao J, Liu J, Liang X, Zhao X, Zhao J, Sun Y, Zhang B, Jiang H, Zhao D, Bian Y, Gao X, Geng L, Li Y, Zhu D, Sun X, Xu JE, Hao C, Ren CE, Zhang Y, Chen S, Zhang W, Yang A, Yan J, Li Y, Ma J, Zhao Y. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet. 2011;43:55–9.
Article
PubMed
CAS
Google Scholar
Shi Y, Zhao H, Shi Y, Cao Y, Yang D, Li Z, Zhang B, Liang X, Li T, Chen J, Shen J, Zhao J, You L, Gao X, Zhu D, Zhao X, Yan Y, Qin Y, Li W, Yan J, Wang Q, Zhao J, Geng L, Ma J, Zhao Y, He G, Zhang A, Zou S, Yang A, Liu J, Li W, Li B, Wan C, Qin Y, Shi J, Yang J, Jiang H, Xu JE, Qi X, Sun Y, Zhang Y, Hao C, Ju X, Zhao D, Ren CE, Li X, Zhang W, Zhang Y, Zhang J, Wu D, Zhang C, He L, Chen ZJ. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet. 2012;44:1020–5.
Article
CAS
PubMed
Google Scholar
Boteju WMM, Karunarathna GDKN, Udayangani SAD, Silva KGH, Wijeyaratne CN. Markers of hyperandrogenism in south Asians with polycystic ovary syndrome. Sri Lanka J Diabetes Endocrinol Metab. 2014;4:3–8.
Article
Google Scholar
Balasooriya S, Fernando MA. Seasonal variation of menarche in Sri Lanka. Ceylon Med J. 1988;33:105–9.
Google Scholar
Jakubowski L. Genetic aspects of polycystic ovary syndrome. Endokrynol Pol. 2005;56(3):285–93.
PubMed
Google Scholar
Legro RS, Kunselman AR, Dodson WC, Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab. 1999;84(1):165–9.
CAS
PubMed
Google Scholar
Barber TM, McCarthy MI, Wass JA, Franks S. Obesity and polycystic ovary syndrome. Clin Endocrinol. 2006;65(2):137–45.
Article
CAS
Google Scholar
Li T, Wu K, You L, Xing X, Wang P, Cui L, Liu H, Cui Y, Bian Y, Ning Y, Zhao H, Tang R, Chen ZJ. Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome. PLoS One. 2013;8:e66250.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tan S, Scherag A, Janssen OE, Hahn S, Lahner H, Dietz T, Scherag S, Grallert H, Vogel CI, Kimmig R, Illig T, Mann K, Hebebrand J, Hinney A. Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS). BMC Med Genet. 2010;11:12.
Article
PubMed
PubMed Central
CAS
Google Scholar
Liu AL, Xie HJ, Xie HY, Liu J, Yin J, Hu JS, Peng CY. Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis. BMC Med Genet. 2017;18(1):89.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ewens KG, Jones MR, Ankener W, Stewart DR, Urbanek M, Dunaif A, Legro RS, Chua A, Azziz R, Spielman RS, Goodarzi MO, Strauss JF 3rd. Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. Fertil Steril. 2011;95(8):2538–41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Russell MA, Morgan NG. Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion. Clin Sci (Lond). 2011;120:403–13.
Article
CAS
Google Scholar
Wijeyaratne CN, Seneviratne Rde A, Dahanayake S, Kumarapeli V, Palipane E, Kuruppu N, et al. Phenotype and metabolic profile of south Asian women with polycystic ovary syndrome (PCOS): results of a large database from a specialist endocrine clinic. Hum Reprod. 2011;26(1):202–13.
Article
CAS
PubMed
Google Scholar
Rutters F, Nieuwenhuizen AG, Bouwman F, Mariman E, Westerterp-Plantenga MS. Associations between a single nucleotide polymorphism of the FTO gene (rs9939609) and obesity-related characteristics over time during puberty in a Dutch children cohort. J Clin Endocrinol Metab. 2011;96:E939–42.
Article
CAS
PubMed
Google Scholar
Magno FCCM, Guaraná HC, Fonseca ACP, Cabello GMK, Carneiro JRI, Pedrosa AP, Ximenes AC, Rosado EL. Influence of FTO rs9939609 polymorphism on appetite, ghrelin, leptin, IL6, TNFα levels, and food intake of women with morbid obesity. Diabetes Metab Syndr Obes. 2018;11:199–207.
Article
PubMed
PubMed Central
Google Scholar
Oakley AE, Clifton DK, Steiner RA. Kisspeptin signaling in the brain. Endocr Rev. 2009;30(6):713–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pankov YA. Kisspeptin and leptin in the regulation of fertility. Mol Biol (Mosk). 2015;49(5):707–15.
Article
CAS
Google Scholar
Smith JT, Acohido BV, Clifton DK, Steiner RA. KiSS-1 neurones are direct targets for leptin in the ob/ob mouse. J Neuroendocrinol. 2006;18(4):298–303.
Article
CAS
PubMed
Google Scholar
Kowalska I, Malecki MT, Straczkowski M, Skupien J, Karczewska-Kupczewska M, Nikolajuk A, Szopa M, Adamska A, Wawrusiewicz-Kurylonek N, Wołczynski S, Sieradzki J, Gorska M. The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes. Diabetes Metab. 2009;35:328–31.
Article
CAS
PubMed
Google Scholar