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Table 2 Risk factors for PCOS

From: In depth analysis of the association of FTO SNP (rs9939609) with the expression of classical phenotype of PCOS: a Sri Lankan study

Risk factor

Genotype

Cases N = 55

Controls N = 110

Crude OR (95% CI)

Adjusted OR (95%CI) Model a

BMI (mean, SE)

–

26.89 ± 0.72

25.25 ± 0.34

1.1 (1.01–1.18)

1.1 (1.01–1.2)

Serum testosterone (mean, SE)

–

4.713 ± 0.46

3.415 ± 0.26

1.2 (1.03–1.29)

 

Serum kisspeptin (mean, SD)

–

4.873 ± 0.24

4.127 ± 0.13

1.37 (1.1–1.71)

1.4 (1.14–1.85)

FTO (rs9939609)

(No, %)

AA

22 (40%)

15 (13.6%)

4.9 (2.16–11.0)

5.7 (2.41–13.63)

AT

13 (23.6%)

23 (20.9%)

2.0 (0.86–4.65)

2.2 (0.9–5.35)

TTR

20 (36.3%)

72 (65.4%)

1

 
  1. aLogistic Regression (LR) model showing adjusted odds ratio (OR) of factors significant for PCOS
  2. Logistic regression analysis was carried out for all the SNPs of Kiss1, GPR54, GnRH, FSHB, FSHR, LHCGR, INSR and FTO along with hormonal (kisspeptin and testosterone levels) characteristics. Only the variables with significant association are shown in the table
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BMC Medical Genetics

ISSN: 1471-2350

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