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Table 2 Results of the meta-analysis, heterogeneity test and Egger’s test

From: The association between interleukin-6 gene -174G/C single nucleotide polymorphism and sepsis: an updated meta-analysis with trial sequential analysis

  Meta-analysis Heterogeneity test Egger’s test
  no. of studies OR (95% CI) P value I 2 P value P value
The association between IL-6 -174G/C polymorphism and the risk of sepsis
Overall       
 GC + CC vs GG 18 0.965 (0.782–1.192) 0.743 72.80% < 0.001 0.694
 CC vs. GC + GG 18 0.992 (0.726–1.356) 0.96 72.90% < 0.001 0.81
 GC vs. GG 16 0.950 (0.798–1.133) 0.57 52.00% 0.008 0.696
 CC vs.GG 16 0.992 (0.686–1.435) 0.966 77.80% < 0.001 0.989
 C vs. G 16 1.014 (0.831–1.236) 0.894 84.20% < 0.001 0.705
Non-adult       
 GC + CC vs GG 9 0.796 (0.522–1.214) 0.29 78.40% < 0.001 0.754
 CC vs. GC + GG 8 0.785 (0.614–1.003) 0.053 41.50% 0.101 0.337
 GC vs. GG 8 0.879 (0.578–1.336) 0.545 72.90% 0.001 0.694
 CC vs.GG 8 0.779 (0.427–1.421) 0.415 69.60% 0.002 0.38
 C vs. G 8 0.896 (0.643–1.248) 0.516 80.10% < 0.001 0.475
Adult       
 GC + CC vs GG 9 1.112 (0.900–1.374) 0.324 59.20% 0.012 0.464
 CC vs. GC + GG 10 1.080 (0.700–1.666) 0.73 79.50% < 0.001 0.73
 GC vs. GG 9 0.988 (0.874–1.117) 0.851 0% 0.711 0.816
 CC vs.GG 9 1.208 (0.766–1.905) 0.416 79.60% < 0.001 0.904
 C vs. G 9 1.124 (0.868–1.455) 0.375 86.40% < 0.001 0.63
Caucasian       
 GC + CC vs GG 16 0.857 (0.699–1.050) 0.136 65.20% < 0.001 0.725
 CC vs. GC + GG 17 0.892 (0.771–1.033) 0.127 6.70% 0.376 0.712
 GC vs. GG 15 0.912 (0.756–1.099) 0.333 52.50% 0.009 0.954
 CC vs.GG 15 0.853 (0.643–1.132) 0.271 55.00% 0.005 0.962
 C vs. G 15 0.913 (0.787–1.059) 0.228 66.20% < 0.001 0.821
Healthy control       
 GC + CC vs GG 10 0.919 (0.686–1.232) 0.574 78.60% < 0.001 0.709
 CC vs. GC + GG 10 0.985 (0.623–1.557) 0.949 84.30% < 0.001 0.979
 GC vs. GG 10 0.894 (0.791–1.010) 0.072 47.30% 0.047 0.871
 CC vs.GG 10 0.896 (0.531–1.511) 0.681 85.50% < 0.001 0.995
 C vs. G 10 0.964 (0.726–1.282) 0.803 89.30% < 0.001 0.747
Mendelian population       
 GC + CC vs GG 13 0,947 (0.768–1.167) 0.607 66.60% < 0.001 0.701
 CC vs. GC + GG 13 0.903 (0.777–1.049) 0.101 27.7%% 0.165 0.807
 GC vs. GG 13 0.971 (0.805–1.171) 0.758 53.10% 0.012 0.645
 CC vs.GG 13 0.880 (0.647–1.197) 0.416 61.50% 0.002 0.698
 C vs. G 13 0.945 (0.806–1.109) 0.489 71.00% < 0.001 0.81
The association between IL-6 -174G/C polymorphism and the mortality of sepsis  
Overall       
 GC + CC vs GG 10 1.050 (0.705–1.563) 0.812 57.90% 0.011 0.059
 CC vs. GC + GG 10 1.299 (0.665–2.538) 0.444 62.20% 0.005 0.173
 GC vs. GG 10 1.045 (0.709–1.540) 0.825 51.10% 0.031 0.143
 CC vs.GG 10 1.340 (0.611–2.939) 0.465 67.00% 0.001 0.113
 C vs. G 10 1.103 (0.795–1.531) 0.558 69.50% 0.001 0.134
Non-adult       
 GC + CC vs GG 4 1.434 (0.810–2.538) 0.216 0% 0.449 0.883
 CC vs. GC + GG 4 2.957 (1.442–6.066) 0.003 0% 0.434 0.684
 GC vs. GG 4 1.098 (0.588–2.050) 0.77 0% 0.746 0.871
 CC vs.GG 4 3.221 (1.431–7.250) 0.005 3% 0.38 0.872
 C vs. G 4 1.631 (1.101–2.416) 0.015 31.90% 0.221 0.783
Adult       
 GC + CC vs GG 6 1.005 (0.593–1.705) 0.985 73.10% 0.002 0.126
 CC vs. GC + GG 6 1.204 (0.342–4.236) 0.772 86.50% < 0.001 0.486
 GC vs. GG 6 1.078 (0.639–1.818) 0.778 70.30% 0.005 0.127
 CC vs.GG 6 0.868 (0.341–2.208) 0.766 66.60% 0.01 0.302
 C vs. G 6 0.940 (0.654–1.352) 0.739 70.90% 0.004 0.377
Caucasian       
 GC + CC vs GG 9 1.206 (0.723–2.007) 0.474 65.70% 0.003 0.094
 CC vs. GC + GG 9 1.376 (0.656–2.884) 0.399 67.90% 0.002 0.097
 GC vs. GG 9 1.143 (0.713–1.834) 0.579 55.50% 0.021 0.174
 CC vs.GG 9 1.430 (0.598–3.420) 0.422 71.30% < 0.001 0.071
 C vs. G 9 1.180 (0.802–1.737) 0.401 73.50% < 0.001 0.101