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Table 1 Main characteristics of the included studies

From: The association between interleukin-6 gene -174G/C single nucleotide polymorphism and sepsis: an updated meta-analysis with trial sequential analysis

First author Year Country Age group Type of case Type of control Ethnicity Case Control HWEa in control
GG GC CC GG GC CC
Schluter B 2002 USA Adult Sepsis, severe sepsis Healthy Caucasian 25 46 24 71 94 42 Yes
Non-survivor Survivor 2 17 6 11 8 6 Yes
Harding D 2003 UK Infant Septicemia Preterm infant Mainly Caucasian 24 27b 30 76b N/A
Balding J 2003 Ireland Adult Meningococcal sepsis Healthy Caucasian 59 97 27 123 209 68 Yes
Non-survivor Survivor 13 10 2 46 87 25 Yes
Treszl A 2003 Hungary Neonate Sepsis VLBWc neonate Caucasian 18 13 2 34 29 7 Yes
Barber RC 2004 USA Adult Severe sepsis ICU patients with no or mild sepsis Mixed 17 19b 69 54b N/A
Ahrens P 2004 Germany Infant Sepsis VLBWc infants Caucasian 24 21 5 97 177 32 No
Michalek J 2006 Czech Republic aged 0–19 years SIRSd, sepsis, severe sepsis, septic shock and MODSe Healthy Caucasian 103 172 48 160 345 139 Yes
McDaniel DO 2006 USA not clearf Sepsis ICU patients African American 16g 0 6g 0 N/A
Caucasian 12g 3 13g 8 N/A
Sipahi T 2006 Turkey aged 0–15 years Severe sepsis Healthy not clear 26 14 4 52 19 6 No
Non-survivor Survivor 9 5 1 17 9 3 Yes
Baier RJ 2006 USA Infant Sepsis VLBWc infant African American 94 18 2 110 9 0 Yes
Caucasian 12 16 3 7 16 3 Yes
Non-survivor Survivor African American 10 1 0 84 17 2 Yes
Caucasian 1 1 1 11 15 2 Yes
Göpel W 2006 Germany Infant Sepsis VLBWc infant Mainly Caucasian 29 50 18 128 143 49 Yes
Sabeinikovs O 2008 Latvia Infant Non-survivor Survivor Caucasian 10 21 13 20 32 7 Yes
Abdel-Hady H 2009 Egypt Neonate Sepsis Neonates investigated for neonatal hyperbilirubinemia Caucasian 17 26 11 28 32 11 Yes
Non-survivor Survivor 2 5 6 15 21 5 Yes
Solé-Violán J 2010 Spain Adult Severe sepsis and septic shock CAPh Caucasian 141 144 36 392 341 84 Yes
Davis SM 2010 USA Female adult Puerperal group streptococcus sepsis Healthy Caucasian 10 11 2 21 22 9 Yes
Carregaro F 2011 Brazil Adult Sepsis, severe sepsis and septic shock Healthy Mainly Caucasiani 49 39 9 94 96 17 Yes
Accardo Palumbo A 2011 Italy aged 13–82 years Sepsis Burned patient not clear 14g 2 22g 4 N/A
Watanabe E 2012 USA Adult Non-survivor Survivor Caucasian 113 149 46 245 363 125 Yes
Martín-Loeches I 2012 Spain Adult Sepsis, severe sepsis and septic shock Healthy Caucasian 581 516 130 438 413 102 Yes
Feng B 2015 China Adult Non-survivor Survivor Asian 42 20 1 139 72 3 Yes
Allam G 2015 Saudi Arabia Infant Early-onset sepsis Healthy not clear 39 20 10 13 32 23 Yes
Lorente L 2016 Spain Adult Non-survivor Survivor not clear 47 36 3 76 74 27 Yes
Mao ZR 2016 China Adult Sepsis Healthy Asian 56 37 95 97 66 37 No
Jimenez-Sousa MA 2017 Spain Adult Septic shock Healthy Not clear 93 90 19 43 51 13 Yes
  1. aHardy-Weinberg equilibrium
  2. bGC and CC
  3. cvery low birth weight
  4. dsystemic inflammatory response syndrome
  5. emultiple organ disorder syndrome
  6. fpatients in surgery intensive care unit
  7. gGG and GC
  8. hcommunity-acquired pneumonia
  9. iCaucasian ancestry mainly, together with small amount of Asian and African ancestry