BMC Medical Genetics

Table 4 Associations of AGT, AGTR1, and ACE polymorphisms with high blood pressure by sex (multivariate analysis)

From: Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents

		Boys		Girls
Model	Genotypes	aOR^a (95% CI)	P value	aOR^a (95% CI)	P value
	AGT
Co-dominant	MM	1.00		1.00
	MT	1.20 (0.70–2.03)	0.509	1.03 (0.58–1.84)	0.926
	TT	0.72 (0.39–1.33)	0.296	0.72 (0.34–1.54)	0.400
Dominant	MM	1.00		1.00
Dominant	MT + TT	0.99 (0.61–1.64)	0.994	0.94 (0.54–1.63)	0.817
Recessive	MM + MT	1.00		1.00
Recessive	TT	0.65 (0.39–1.07)	0.091	0.71 (0.37–1.36)	0.301
Additive		0.85 (0.63–1.15)	0.304	0.87 (0.60–1.25)	0.448
	AGTR1
Co-dominant	AA	1.00		1.00
	AC	0.84 (0.53–1.33)	0.451	0.99 (0.59–1.68)	0.986
	CC	0.66 (0.29–1.48)	0.309	1.21 (0.44–3.33)	0.771
Dominant	AA	1.00		1.00
Dominant	AC + CC	0.80 (0.52–1.24)	0.323	1.02 (0.62–1.69)	0.929
Recessive	AA + AC	1.00		1.00
Recessive	CC	0.71 (0.32–1.56)	0.391	1.21 (0.45–3.25)	0.700
Additive		0.82 (0.58–1.15)	0.256	1.05 (0.70–1.57)	0.821
	ACE
Co-dominant	II	1.00		1.00
	ID	2.05 (1.19–3.53)	0.010	0.92 (0.51–1.67)	0.793
	DD	1.43 (0.76–2.69)	0.226	0.89 (0.44–1.82)	0.749
Dominant	II	1.00		1.00
Dominant	ID + DD	1.82 (1.09–3.04)	0.022	0.91 (0.52–1.60)	0.752
Recessive	II + ID	1.00		1.00
Recessive	DD	0.89 (0.53–1.48)	0.646	0.94 (0.52–1.70)	0.834
Additive		1.20 (0.88–1.63)	0.253	0.94 (0.66–1.35)	0.745

Abbreviations: AGT angiotensinogen, AGTR1 angiotensin II receptor 1, ACE angiotensin-converting enzyme, aOR adjusted odds ratio, CI confidence intervals
^aadjusted for the body mass index and waist circumference

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