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Table 4 Associations of AGT, AGTR1, and ACE polymorphisms with high blood pressure by sex (multivariate analysis)

From: Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents

   Boys Girls
Model Genotypes aORa (95% CI) P value aORa (95% CI) P value
  AGT     
Co-dominant MM 1.00   1.00  
MT 1.20 (0.70–2.03) 0.509 1.03 (0.58–1.84) 0.926
TT 0.72 (0.39–1.33) 0.296 0.72 (0.34–1.54) 0.400
Dominant MM 1.00   1.00  
MT + TT 0.99 (0.61–1.64) 0.994 0.94 (0.54–1.63) 0.817
Recessive MM + MT 1.00   1.00  
TT 0.65 (0.39–1.07) 0.091 0.71 (0.37–1.36) 0.301
Additive   0.85 (0.63–1.15) 0.304 0.87 (0.60–1.25) 0.448
  AGTR1     
Co-dominant AA 1.00   1.00  
AC 0.84 (0.53–1.33) 0.451 0.99 (0.59–1.68) 0.986
CC 0.66 (0.29–1.48) 0.309 1.21 (0.44–3.33) 0.771
Dominant AA 1.00   1.00  
AC + CC 0.80 (0.52–1.24) 0.323 1.02 (0.62–1.69) 0.929
Recessive AA + AC 1.00   1.00  
CC 0.71 (0.32–1.56) 0.391 1.21 (0.45–3.25) 0.700
Additive   0.82 (0.58–1.15) 0.256 1.05 (0.70–1.57) 0.821
  ACE     
Co-dominant II 1.00   1.00  
ID 2.05 (1.19–3.53) 0.010 0.92 (0.51–1.67) 0.793
DD 1.43 (0.76–2.69) 0.226 0.89 (0.44–1.82) 0.749
Dominant II 1.00   1.00  
ID + DD 1.82 (1.09–3.04) 0.022 0.91 (0.52–1.60) 0.752
Recessive II + ID 1.00   1.00  
DD 0.89 (0.53–1.48) 0.646 0.94 (0.52–1.70) 0.834
Additive   1.20 (0.88–1.63) 0.253 0.94 (0.66–1.35) 0.745
  1. Abbreviations: AGT angiotensinogen, AGTR1 angiotensin II receptor 1, ACE angiotensin-converting enzyme, aOR adjusted odds ratio, CI confidence intervals
  2. aadjusted for the body mass index and waist circumference