Fig. 3From: Insertion of an extra copy of Xq22.2 into 1p36 results in functional duplication of the PLP1 gene in a girl with classical Pelizaeus-Merzbacher diseaseHypothetical model of mechanism for the insertion of PLP1 in 1p36. Based on the FoSTeS mechanism proposed by Lupski and coll. [10] (upper situation) we propose an alternative model to explain the insertion of an extra copy of the PLP1 gene in chromosome 1p36 (lower situation)Back to article page