Figure 2

Mean P value differences (observed-random) in 50,000 simulations. The right panel shows a skewed distribution of simulated random minus actual Kaplan-Meier log-rank P values (N = 89), indicating that observed P values collectively were lower than expected. With the removal of 16 positive associations (P < 0.1), the remaining genetic variables closely approximated a random distribution, as shown in the left panel.