Rader DJ, Cohen J, Hobbs HH: Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. J Clin Invest. 2003, 111: 1795-1803. 10.1172/JCI200318925.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang L, Fan C, Topol SE, Topol EJ, Wang Q: Mutation of MEF2A in an inherited disorder with features of coronary artery disease. Science. 2003, 302: 1578-1581. 10.1126/science.1088477.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang Q, Rao S, Shen GQ, Li L, Moliterno DJ, Newby LK, Rogers WJ, Cannata R, Zirzow E, Elston RC, Topol EJ: Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am J Hum Genet. 2004, 74: 262-271. 10.1086/381560.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marenberg ME, Risch N, Berkman LF, Floderus B, de Faire U: Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med. 1994, 330: 1041-1046. 10.1056/NEJM199404143301503.
Article
CAS
PubMed
Google Scholar
Tegos TJ, Kalodiki E, Sabetai MM, Nicolaides AN: The genesis of atherosclerosis and risk factors: a review. Angiology. 2001, 52: 89-98.
Article
CAS
PubMed
Google Scholar
Burke B, Stewart CL: Life at the edge: the nuclear envelope and human disease. Nat Rev Mol Cell Biol. 2002, 3: 575-585. 10.1038/nrm879.
Article
CAS
PubMed
Google Scholar
Hegele RA, Kraw ME, Ban MR, Miskie BA, Huff MW, Cao H: Elevated serum C-reactive protein and free fatty acids among nondiabetic carriers of missense mutations in the gene encoding lamin A/C (LMNA) with partial lipodystrophy. Arterioscler Thromb Vasc Biol. 2003, 23: 111-116. 10.1161/01.ATV.0000047460.27435.B8.
Article
CAS
PubMed
Google Scholar
De Sandre-Giovannoli A, Bernard R, Cau P, Navarro C, Amiel J, Boccaccio I, Lyonnet S, Stewart CL, Munnich A, Le Merrer M, Levy N: Lamin a truncation in Hutchinson-Gilford progeria. Science. 2003, 300: 2055-10.1126/science.1084125.
Article
CAS
PubMed
Google Scholar
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS: Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature. 2003, 423: 293-298. 10.1038/nature01629.
Article
CAS
PubMed
Google Scholar
Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI: Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997, 390: 45-51. 10.1038/36285.
Article
CAS
PubMed
Google Scholar
Shimada T, Takeshita Y, Murohara T, Sasaki K, Egami K, Shintani S, Katsuda Y, Ikeda H, Nabeshima Y, Imaizumi T: Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse. Circulation. 2004, 110: 1148-1155. 10.1161/01.CIR.0000139854.74847.99.
Article
PubMed
Google Scholar
Arking DE, Krebsova A, Macek M, Macek M, Arking A, Mian IS, Fried L, Hamosh A, Dey S, McIntosh I, Dietz HC: Association of human aging with a functional variant of klotho. Proc Natl Acad Sci U S A. 2002, 99: 856-861. 10.1073/pnas.022484299.
Article
CAS
PubMed
PubMed Central
Google Scholar
Arking DE, Becker DM, Yanek LR, Fallin D, Judge DP, Moy TF, Becker LC, Dietz HC: KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet. 2003, 72: 1154-1161. 10.1086/375035.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lin F, Worman HJ: Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C. J Biol Chem. 1993, 268: 16321-16326.
CAS
PubMed
Google Scholar
Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, et al: Initial sequencing and analysis of the human genome. Nature. 2001, 409: 860-921. 10.1038/35057062.
Article
CAS
PubMed
Google Scholar
dbSNP. [http://www.ncbi.nlm.nih.gov/SNP/]
Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2004
Google Scholar
Fallin D, Cohen A, Essioux L, Chumakov I, Blumenfeld M, Cohen D, Schork NJ: Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease. Genome Res. 2001, 11: 143-151. 10.1101/gr.148401.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chapman DG, Nam JM: Asymptotic power of chi square tests for linear trends in proportions. Biometrics. 1968, 24: 315-327.
Article
CAS
PubMed
Google Scholar
Cardon LR, Bell JI: Association study designs for complex diseases. Nat Rev Genet. 2001, 2: 91-99. 10.1038/35052543.
Article
CAS
PubMed
Google Scholar
Hegele RA: SNP judgments and freedom of association. Arterioscler Thromb Vasc Biol. 2002, 22: 1058-1061. 10.1161/01.ATV.0000026801.56080.14.
Article
CAS
PubMed
Google Scholar
Botstein D, Risch N: Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat Genet. 2003, 33 (Suppl): 228-237. 10.1038/ng1090.
Article
CAS
PubMed
Google Scholar
Terwilliger JD, Haghighi F, Hiekkalinna TS, Goring HH: A bias-ed assessment of the use of SNPs in human complex traits. Curr Opin Genet Dev. 2002, 12: 726-734. 10.1016/S0959-437X(02)00357-X.
Article
CAS
PubMed
Google Scholar
Colhoun HM, McKeigue PM, Davey Smith G: Problems of reporting genetic associations with complex outcomes. Lancet. 2003, 361: 865-872. 10.1016/S0140-6736(03)12715-8.
Article
PubMed
Google Scholar
Freedman ML, Reich D, Penney KL, McDonald GJ, Mignault AA, Patterson N, Gabriel SB, Topol EJ, Smoller JW, Pato CN, Pato MT, Petryshen TL, Kolonel LN, Lander ES, Sklar P, Henderson B, Hirschhorn JN, Altshuler D: Assessing the impact of population stratification on genetic association studies. Nat Genet. 2004, 36: 388-393. 10.1038/ng1333.
Article
CAS
PubMed
Google Scholar
Greenland P, Knoll MD, Stamler J, Neaton JD, Dyer AR, Garside DB, Wilson PW: Major risk factors as antecedents of fatal and nonfatal coronary heart disease events. Jama. 2003, 290: 891-897. 10.1001/jama.290.7.891.
Article
PubMed
Google Scholar
Zhao LP, Hsu L, Davidov O, Potter J, Elston RC, Prentice RL: Population-based family study designs: an interdisciplinary research framework for genetic epidemiology. Genet Epidemiol. 1997, 14: 365-388. 10.1002/(SICI)1098-2272(1997)14:4<365::AID-GEPI3>3.0.CO;2-2.
Article
CAS
PubMed
Google Scholar
Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D: The structure of haplotype blocks in the human genome. Science. 2002, 296: 2225-2229. 10.1126/science.1069424.
Article
CAS
PubMed
Google Scholar