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Genetic studies of the Roma (Gypsies): a review

BMC Medical Genetics20012:5

https://doi.org/10.1186/1471-2350-2-5

©  Kalaydjieva et al, licensee BioMed Central Ltd. 2001

  • Received: 15 January 2001
  • Accepted: 2 April 2001
  • Published:
Open Peer Review reports

Abstract

Background

Data provided by the social sciences as well as genetic research suggest that the 8-10 million Roma (Gypsies) who live in Europe today are best described as a conglomerate of genetically isolated founder populations. The relationship between the traditional social structure observed by the Roma, where the Group is the primary unit, and the boundaries, demographic history and biological relatedness of the diverse founder populations appears complex and has not been addressed by population genetic studies.

Results

Recent medical genetic research has identified a number of novel, or previously known but rare conditions, caused by private founder mutations. A summary of the findings, provided in this review, should assist diagnosis and counselling in affected families, and promote future collaborative research. The available incomplete epidemiological data suggest a non-random distribution of disease-causing mutations among Romani groups.

Conclusion

Although far from systematic, the published information indicates that medical genetics has an important role to play in improving the health of this underprivileged and forgotten people of Europe. Reported carrier rates for some Mendelian disorders are in the range of 5 -15%, sufficient to justify newborn screening and early treatment, or community-based education and carrier testing programs for disorders where no therapy is currently available. To be most productive, future studies of the epidemiology of single gene disorders should take social organisation and cultural anthropology into consideration, thus allowing the targeting of public health programs and contributing to the understanding of population structure and demographic history of the Roma.

Keywords

  • Newborn Screening
  • Autosomal Dominant Polycystic Kidney Disease
  • Epidermolysis Bullosa
  • Founder Population
  • Single Gene Disorder

Introduction

The Roma (Gypsies) became one of the peoples of Europe around one thousand years ago, when they first arrived in the Balkans [1,2]. The current size of the European Romani population, around 8 million [2], is equivalent to that of an average European country (Figure 1). While human rights and socio-economic issues related to the Roma are increasingly becoming the focus of political debate and media coverage throughout Europe, their poor health status [[3–6]] is rarely discussed and still awaits the attention of the medical profession.
Figure 1
Figure 1

Romani population size in different European countries The collection of this type of data depends on declared ethnic identity which, in the case of the Roma, can be affected by a number of political and social circumstances. The estimates in the figure are the average of the numbers provided by different sources, such as census data, ministries of internal affairs and human rights organizations [2].

This review of genetic studies of the Roma was prompted by two recent developments: (i) Studies conducted over the last decade have resulted in the identification of a number of novel single gene disorders and disease-causing mutations. The accumulating data are already sufficient to outline a pattern and draw conclusions about public health policies and future research. (ii) The economic and political changes in Eastern Europe and the wars in former Yugoslavia have led to the west-bound migration of large numbers of Roma [7,8], changing the traditional demographic profile of Gypsy minorities across Europe. A predictable consequence of this new diaspora is that medical practitioners in many countries will encounter Romani patients with previously unknown or very rare disorders. A summary of the available information should facilitate diagnostic investigations and counselling in these affected families and stimulate international collaboration.

Materials and Methods

Literature searches were performed using the U.S.A National Library of Medicine PubMed/MEDLINE databases for the period 1960 to December 2000. Database searches using the keyword "Gypsies" identified 297 articles whilst the keyword "Gypsy" produced 573 articles. The discrepancy is due mainly to the inclusion of articles about the "gypsy retransposable element" and the "gypsy moth". Searches using the terms "Roma", "Romani" and "Romany" yielded results that were not relevant to the topic (eg. Roma, the capital of Italy) or else incomplete.

The majority of the 297 articles dealt with issues beyond the focus of this review, namely social problems related to the health of the Roma (28.6%), or general medical problems (29.6%). The remainder were reports on genetic research, of which 41 studies (13.8%) were in the field of clinical genetics, 44 (14.8%) were molecular studies of genetic disorders, and 39 (13.1%) covered population genetic research. In the clinical and molecular genetics fields, we have given preference to publications which were not limited to single case descriptions, and dealt with disorders with public health impact. Population genetics papers were selected on the basis of the compatibility of study design, specifically the analysis of comparable polymorphic systems.

Complementary data on history, linguistics, cultural anthropology and demography were found through standard library and bibliographic searches, and included publications recommended by consulting experts in Romani studies (Drs. Elena Marushiakova and Vesselin Popov from the Bulgarian Academy of Sciences and Dr. Ian Hancock from the University of Texas at Austin).

The "Track Record" of Genetics

Genetic studies of the Roma have been conducted for over 70 years, with thousands of individuals sampled across Europe. During the years of the Third Reich, Gypsies, together with Jews, attracted the special attention of German geneticists [9]. A grant proposal signed by Nobel prize winner Ferdinand Sauerbruch and funded by the Deutsche Forschungsgemeinschaft designed the "genetic and medical research" at the death camp in Auschhwitz [9]. The Race Hygiene and Population Biology Research Centre, established in 1936, organised thorough records of Jewish and Romani pedigrees and provided "the scientific basis" for the "final solution", the annihilation of millions of Jews and Roma in the concentration camps of Nazi-occupied Europe.

Post-war genetic research has been preoccupied with the Indian origins of the Roma [[10–16]], pursuing the "Indian connection" even in studies meant to focus on severe genetic disorders [17]. Most studies have remained in the realm of scientific exploration, away from the health needs of the Roma. Many publications display judgemental and paternalistic attitudes, that would be considered unacceptable if used with regard to other populations.

This historical "track record", the persisting practices of discrimination and marginalisation [[3–6]], and the fact that, unlike the Jews, the Finns and the French Canadians, the Roma are still the "object" of investigations conducted by outsiders, are all likely to impact on the attitudes of the Roma towards genetics. Building up the trust and collaboration necessary for both public health programs and research, should become a goal of the health care systems of Europe.

Population Genetics

Population genetic studies have used mostly "classical" polymorphisms to investigate Romani individuals from different European counties and address three main questions: (i) similarity between Roma and Indians; (ii) relatedness to European populations; (iii) affinities between Romani populations from different countries [[10–24]]. Single locus comparisons have resulted in controversy, with some pointing to close genetic affinity between Roma and Indians, and others indicating that the Roma are indistinguishable from Europeans. Heterogeneity between countries has become apparent and has led to the conclusion that the European Roma are composed of two different populations, characterised respectively by a high and a low frequency of blood group B [23], or defined as East and West European Roma, with the former closely related to Indian populations [16]. Heterogeneity of Romani populations within the same country has been suggested by the very small number of studies addressing this issue [19,21,25,26].

In an attempt to summarise the existing data, we have conducted a multilocus re-analysis of several marker systems using comparable studies of the Roma in different European countries [11,22,23,24,26,27], Europeans [[28–33]] and north Indian populations [[34–36]]. The comparisons (Figure 2, Table 1) provide a general indication that most of the Roma are genetically closer to Indians than to European populations, hardly surprising in view of the linguistic theories on the Indian origins of the Roma proposed two centuries ago [1]. More importantly, the analysis highlights the internal diversity of the Roma, who appear to be genetically far more heterogeneous than autochthonous European populations.
Figure 2
Figure 2

Multilocus comparison between Romani populations from different European countries, autochthonous European populations and populations from north India The polymorphic systems included in the analysis comprised A1A2BO, MN, haptoglobin and Rh (CDE), with a total of 11 independent alleles. Information on these markers was available for the Roma in Slovakia (n = 350) [26], Hungary (n = 507) [11], England (n = 109) [23], Slovenia (n = 350) [27], Sweden (n = 115) [24] and Wales (n = 84) [22], for non-Roma Europeans (n = 5169) and for two north Indian populations, Rajput (n = 175) [34,35] and Punjabi (n = 140) [35,36]. Genetic distances between pairs of populations were computed by means of Reynold's coancenstry coefficient [84] and displayed as a neighbour-joining tree [85]. The robustness of the branches in the tree was assessed with a bootstrap approach [86]. The analysis was conducted using the PHYLIP 3.57c package [87].

Table 1

Multi-locus reanalysis of previously published data on European Roma

Populations

Proportion of the variance explained by differences

 

between groups

within groups

All Roma (n = 1287) versus

1.81 ± 1.45%

0.58 ± 0.29%

non-Roma Europeans

  

(n = 5169)

  

Roma (n = 1287) versus

0.36 ± 0.69%

2.8 ± 0.39%

North Indians (n = 315)

  

Between Romani

3.47 ± 0.46%

 

populations (n = 1287) in

  

Europe

  

Between European

0.19 ± 0.12%

 

Populations (n = 5169)

  

The populations and references included in the comparison are as indicated in figure 2. Genetic variance was apportioned between and within populations and between and within groups of populations by means of the Analysis of Molecular Variance [88], as implemented in the Arlequin 1.1 package [89].

Genetic Disorders of the Roma

Diseases and mutations identified to-date

As a result of traditionally low socio-economic status and limited access of the Roma to health care, their unique genetic heritage has long escaped the attention of European medicine and is now being randomly "discovered".

To date, nine Mendelian disorders caused by private "Romani" mutations have been described (Table 2).
Table 2

Mendelian disorders of the Roma caused by private founder mutations

Disorder

OMIM*

Inheritance

Map

Gene

Mutation

Ref.

   

Location

   

Primary congenital

231300

AR

2p21

CYP1B1

E387K

45,54

Glaucoma

      

Galactokinase

230200

AR

17q24

GK1

P28T

44

Deficiency

      

Polycystic kidney

173900

AD

4q21-q23

PKD2

R306X**

90

Disease

      

Hereditary motor and

601455

AR

8q24

NDRG1

R148X

37,39

Sensory neuropathy-Lom

      

Hereditary motor and

605285

AR

10q23

  

40

Sensory neuropathy-Russe

      

Congenital cataracts facial

604168

AR

18qter

  

42

dysmorphism neuropathy

      

Limb girdle muscular

253700

AR

13q12

SGCG

C283Y

43,65,

dystrophy type 2C

     

91

Congenital myasthenia

254210

AR

17p13

CHRNE

1267delG

46

Glanzmann

273800

AR

17q21

ITGA2B

IVS15DS,

64,92

Thrombasthenia

    

G-A+1

 

* Using the OMIM numbers, detailed clinical information can be obtained at http://www3.ncbi.nlm.nih.gov/Omim/ ** The R306X mutation in PKD2 has been identified in Romani families from Bulgaria. It has not been confirmed in the Hungarian ADPKD families, but appears probable because of a reported common migration history of all affected groups.

The list includes three novel neurological disorders, namely hereditary motor and sensory neuropathies type Lom (HMSN-L) [[37–39]] and type Russe (HMSN-R) [40], and the congenital cataracts facial dysmorphism neuropathy syndrome (CCFDN) [41,42].

In addition, a number of previously known but rare disorders have been identified and shown to be caused by novel private mutations (Table 2). Examples include limb-girdle muscular dystrophy type 2C (LGMD2C) [43], galactokinase deficiency [44], primary congenital glaucoma [45], and congenital myasthenia [46].

In view of the lack of systematic studies, the list cannot be comprehensive and is likely to represent the biases and interests of individual medical researchers working in this field. Data in the literature, particularly from the Spanish Collaborative Study of Congenital Malformations [47], point to the existence of a number of additional rare single gene disorders, whose molecular basis is still to be identified. These include hereditary idiopathic torsion dystonia (ITD) [48], epidermolysis bullosa [49], albinism [49], and some rare autosomal recessive malformation syndromes, such as Bowen-Conradi, Jarcho-Levin, Meckel, Smith-Lemli-Opitz, and Fraser [47,49].

A third group of Mendelian disorders includes common conditions, where the mutation prevalent in the surrounding or in global populations is likely to have been introduced by admixture, for example cystic fibrosis and delF508 [50], phenylketonuria and the R252W and IVS10nt546 mutations [51,52], and medium chain acyl-coenzyme A dehydrogenase (MCAD) deficiency and G985 [53].

Molecular genetic findings

With the exception of phenylketonuria, Mendelian disorders have been described as genetically homogeneous, with a single mutation accounting for all affected individuals and related polymorphic haplotypes unambiguously indicating a common origin and founder effect [[37–40],[42–46]].

At the same time, many studies emphasise the small size of the conserved region of homozygosity and the diversity of disease haplotypes observed even within single affected kindreds [37,40,42,44,54] (Figure 3). Haplotype diversification, generated by numerous historical recombinations and marker mutations [39] as a consequence of the old age [37,43] and high frequencies of disease-causing mutations, has important implications for gene mapping studies: (i) Homozygosity mapping, relying on consanguinity in the affected families, is not applicable in studies using the standard genetic maps and can result in spuriously negative results [54]. (ii) The diversity of historical recombinations becomes a powerful tool in the subsequent refined genetic mapping and positional cloning of disease genes [55,39].
Figure 3
Figure 3

Genetic mapping of hereditary motor and sensory neuropathy type Russe (HMSN-R): findings in the region of linkage on chromosome 10q23 This affected family originates from a closed endogamous Romani group where consanguineous marriages are common. The linkage study was conducted using the ABI Prism Linkage Mapping Sets LMS and LMS version 2 (PE Biosystems), with an average intermarker distance of 10 cM. The ABI panel markers flanking the HMSN-R region (shown in blue) presented with different alleles in the affected individuals. Haplotype heterozygosity, resulting from historical recombinations and a recent cross-over event (individual R-11), extended into the 10 cM interval containing the gene and could have resulted in exclusion of the region if homozygosity mapping had been used. In the set of affected families included in the original study [40], the conserved region of homozygosity (red bars) was found to span only <500 kb. Courtesy of Dr. Tamara Rogers.

Epidemiological data

Reported gene frequencies are high for both private and "imported" mutations, and often exceed by an order of magnitude those for global populations. For example, galactokinase deficiency whose worldwide frequency is 1:150,000 to 1:1,000,000 [56,57] affects 1 in 5,000 Romani children [44]; autosomal dominant polycystic kidney disease (ADPKD) has a global prevalence of 1:1000 individuals worldwide [58] and 1:40 among the Roma in some parts of Hungary [17]; primary congenital glaucoma ranges between 1:5,000 and 1:22,000 worldwide [59,60] and about 1:400 among the Roma in Central Slovakia [61,62].

Carrier rates for a number of disorders have been estimated to be in the 5 to 20% range (Table 3).
Table 3

Reported carrier rates for single gene disorders among the Roma

Disorder

Country

General

High-risk

Ref.

  

Roma

groups

 

Primary congenital glaucoma

Slovakia

5%

*11%

45,54

Galactokinase

Bulgaria

2%

*4%-5%

44

Deficiency

    

Autosomal dominant polycystic

Hungary

 

2.4%

17

kidney disease

    

Hereditary motor and sensory

Bulgaria

*2%

*20%

37,39

neuropathy-Lom

    

Limb girdle muscular dystrophy

**Bulgaria

2%

6%

93,66

type 2C

    

MCAD deficiency

***Spain

 

*2.5%-10%

53

Phenylketonuria

Czecho

6%

 

94

 

slovakia

   

Oculocutaneous albinism

Spain

3.4%

 

49

Fraser syndrome

Spain

2.7%

 

47

Epidermolysis bullosa

Spain

2.4%

 

49

Most estimates are based on prevalence figures. *Carrier rates determined through direct mutation detection are indicated in red. **The LGMD2C carrier rates for the general Romani population of Bulgaria are probably an overestimate since the screening was conducted in a geographical region where the high risk groups are clustered. ***The screening for the G985 mutation in Spain, performed in Gypsy groups residing in different parts of the country, revealed substantial differences between groups.

Although incomplete, the available data already lead to some practical conclusions: (i) What may appear to be a novel disorder confined to a single family, could in fact be an indication of a common problem affecting large numbers of individuals. Research should therefore extend beyond case descriptions and aim at more comprehensive epidemiological information. (ii) The emphasis on consanguinity in affected families displaces the focus from an obvious need for public health intervention to patterns of personal behaviour. In the face of the reported high gene frequencies, consanguinity is no more relevant than it would be as a cause of beta-thalassemia in Mediterranean countries. (iii) High gene frequencies may result in the parallel segregation of phenotypically similar but genetically distinct disorders within the same kindred [40,42]. This clustering should be borne in mind in diagnostic studies, where assumptions based on pedigree structure should be avoided and independent clinical and genetic assessment should be conducted in all cases.

Research into Mendelian disorders has provided ample evidence of genetic stratification, with mutations occurring at high frequencies in some Romani communities and altogether absent in others, located in close geographic proximity. In some cases, such as Glanzmann thrombasthenia [63,64], LGMD2C [65,66], galactokinase deficiency [44], CCFDN [42] and HMSN-R [40], the identity of the affected groups has been specified. Other studies, for example of congenital glaucoma [61,62] and ADPKD [17] provide only an indication of the area of residence of the affected communities. In the few cases where gene frequencies can be compared between high-risk groups and the general Romani population of the same country, substantial differences become apparent (Table 3).

At the same time, founder mutations have spread with the Romani diaspora and are shared by affected individuals throughout Europe (Figure 4). International collaboration has already made a substantial contribution to the study of disease phenotypes in large samples of genetically homogeneous patients [46, [67–71]] as well as to the refined mapping of disease genes [55]. Such collaboration will be essential for future research into new disorders, founder mutations and factors modifying disease severity, and for understanding the epidemiology of genetic diseases of the Roma. The first steps to European collaboration have been made, with the founding of the Gypsy Genetic Heritage Consortium in 1997, and the forthcoming ENMC workshop on neuromuscular disorders in Gypsies.
Figure 4
Figure 4

Distribution of reported founder mutations in Europe The figure is based on available information referring to the following disorders: • Infantile cataracts due to galactokinase deficiency in Bulgaria [44], Austria [95], Switzerland [96], Italy [97], Hungary and Spain [our unpublished findings]. • Hereditary motor and sensory neuropathy - Lom in Bulgaria [37,38], Italy [68], Slovenia [69], Germany [70], Spain [71], France and Romania [55] and Hungary [our unpublished findings]. • Congenital cataracts facial dysmorphism neuropathy syndrome in Bulgaria [41,42], Romania, Hungary and the United States [our unpublished findings]. • Limb girdle muscular dystrophy type 2C in France, Spain, Italy, Germany [43], Portugal [91] and Bulgaria [65,66,93]. • Congenital myasthenia in Serbia, Macedonia, Greece, Bohemia and Germany [46]. • Hereditary motor and sensory neuropathy - Russe in Bulgaria [40], Romania and Spain [our unpublished findings]. The existing data are the product of ad-hoc collaborative studies and are not likely to represent the true spread of Romani founder mutations. The distribution of LGMD2C in Western Europe and in Bulgaria leads to the prediction that the disorder occurs and awaits detection along the entire European migration route, spanning the Balkans and Central Europe. Filling the gaps in the map will be particularly useful in the case of treatable disorders which are strong candidates for newborn screening, such as galactokinase deficiency and congenital myasthenia.

Discussion

The pattern emerging from genetic research is that of a conglomerate of founder populations which extend across Europe but at the same time differ within individual countries, and whose demographic history, internal structure and relationships are poorly understood. An insight is provided by the social sciences.

The 18th century theory on the Indian origins of the Roma [reviewed in 1], is based on the similarities between Romani and languages spoken in the Indian subcontinent and is supported by genetic evidence. However the lack of close relationship to any specific language or dialect has left unresolved the question of the original ethnic composition of the proto-Roma, with both single [72,73] and diverse [74] origins proposed by linguists. Translated into the language of genetics, this is a relevant question related to the homogeneity or diversity of the founding population.

Inferred from linguistic influences retained in all Romani dialects, the major migration routes pass through Persia, Armenia, Greece and the Slavic-speaking parts of the Balkans [1]. The first documents pointing to the arrival of the Roma in the Balkans date from the 11th-12th century [1,75]. By the 15th century, mention of their presence can be found in historical records from all parts of Europe [1,2].

Historical demographic data are limited, however tax registries and census data give an approximate idea of population size and rate of demographic growth through the centuries (Table 4). A small size of the original population is suggested by the fact that although most of the migrants arriving in Europe in the 11th-12th century remained within the limits of the Ottoman Empire [1,75], the overall number of Roma in its Balkan provinces in the 15th century was estimated at only 17,000.
Table 4

Data on the historical demography of the Roma [ref. 1,75,98]

Source

Period

Region

Population size

Ottoman Empire Tax

15th century

Balkan Provinces

17,000

Registries

16th century

Balkan Provinces

65,000

 

16th century

Bulgaria only

5,700

Ottoman Empire

17th century

Balkan Provinces

11-15,000 males of

Army List

  

military age

Austro-Hungarian Empire

1772

Transylvania

39,000

Census Data

1837

Transylvania

53,000

 

1893

Transylvania

105,000

Bulgaria

1881-1885

Bulgaria

62,324

Census Data

   

During its subsequent history in Europe, this founder population split into numerous socially divided and geographically dispersed endogamous groups, with historical records from different parts of the continent consistently describing the travelling Gypsies as "a group of 30 to 100 people led by an elder" [1,2]. These splits, a possible compound product of the ancestral tradition of the jatis of India, and the new social pressures in Europe (e.g. Gypsy slavery in Romania [76] and repressive legislation banning Gypsies from most western European countries [1,2]), can be regarded as secondary bottlenecks, reducing further the number of unrelated founders in each group. The historical formation of the present-day 8 million Romani population of Europe is therefore the product of the complex initial migrations of numerous small groups, superimposed on which are two large waves of recent migrations from the Balkans into Western Europe, in the 19th - early 20th century, after the abolition of slavery in Rumania [1,2,76] and over the last decade, after the political changes in Eastern Europe [7,8].

The Group is still the primary building block of the social organisation of the Roma [1,2]. Group identity and the ensuing divisions and rules of endogamy are based on tradition, customs and organs of self-rule, language and dialects, trades, history of migrations, and religion. Individual groups can be classified into major metagroups [1,2,75]: the Roma of East European extraction; the Sinti in Germany and Manouches in France and Catalonia; the Kaló in Spain, Ciganos in Portugal and Gitans of southern France; and the Romanichals of Britain [1]. The greatest diversity is found in the Balkans, where numerous groups with well defined social boundaries exist. The 700-800,000 Roma in Bulgaria belong to three metagroups, comprising a large number of smaller groups [75].

Linguistics, history and cultural anthropology suggest two major, equally plausible historical scenarios that could lead to a "jigsaw puzzle" of founder populations: (i) a genetically substructured ancestral population, where the old social traditions of strict endogamy have been retained and subsequent splits of the comprising groups have enhanced the original genetic differences; (ii) a small homogeneous ancestral population spawning numerous subgroups where strong drift effects have resulted in substantial genetic divergence. Genetic research has indeed faced the "jigsaw puzzle" and has thus far been unable to resolve it. The genetic data provide evidence of population stratification, however a closer examination is precluded by the random cross-section sampling design of most population genetic studies, where the traditional social organisation and self-identity of the Roma have been ignored and subjects classified on the basis of the political boundaries of Europe. The relationship between social organisation and genetic structure does not appear to be straightforward and is still to be addressed in population genetic research based on the long standing identity of Gypsy groups. The issue is of relevance to public health policies and the targeted prevention of mendelian disorders, as well as to future studies of genetically complex disorders.

The existing information on single gene disorders is certainly not exclusive to the Roma. The phenomenon of clustering of rare disorders and private founder mutations has been studied in detail in well characterised founder populations, such as the Jews [77,78], Finns [79,80] and French Canadians [81]. Unlike the above examples however, genetic studies of the Roma have failed to take the immediate benefits of research back to the individuals and families that have been the object of research. Yet by now it should be obvious that genetics has an important role to play in improving the quality of health care for the Roma. Treatable disorders such as galactokinase and MCAD deficiency, with an expected incidence of affected births in the range of 1:1,000 to 1:5,000, meet the standard criteria for newborn screening more than does phenylketonuria, with its average incidence of 1:10,000. Adding the simple, sensitive and specific mutation tests to existing newborn screening programs would be technically simple and highly efficient due to the homogeneous genetic basis of the disorders.

Carrier testing should be made available to Romani communities at high risk for severe untreatable disorders. Information on the identity of affected Romani populations is important for public health intervention since it would allow the planning and facilitate the implementation of targeted prevention programs, especially in the Eastern European countries where economic resources are limited. The importance of the educational component of such programs has already been demonstrated by the highly successful prevention of Tay-Sachs disease among Ashkenazi Jews [82] and the failure of sickle-cell screening among Afro-Americans [83]. This component would be particularly important for a population like the Roma, which has been subject to racism and persecution throughout its co-existence with European societies.

The attention of geneticists is increasingly attracted by genetically isolated populations in the third world. In terms of living standards and the major health indicators, the Roma are much closer to the developing world than to their European neighbours [3]. This forgotten people of Europe can be regarded as a test case for the capacity of genetics to provide better health.

Declarations

Acknowledgements

We thank the Romani families and communities, and the numerous colleagues in different countries who have made our research into the genetics of the Roma possible, the members of the Gypsy Genetic Heritage Consortium Prof. J.-C. Kaplan, Prof. A. Urtizberea, Prof. J.-P. Liegeois, Drs. M. Jeanpierre and L. Merlini for their commitment to international collaboration, and Drs. E. Marushiakova, V. Popov and I. Hancock for enlightening discussions of the ethnology, history and linguistics of the Roma. Special thanks to the research team at the Centre for Human Genetics of Edith Cowan University.

L.K. wishes to acknowledge funding from The Wellcome Trust, The National Health and Medical Research Council of Australia, The Muscular Dystrophy Association of the US, L'Assoçiation Française contre les Myopathies, The Australian Research Council and Edith Cowan University.

Authors’ Affiliations

(1)
Centre for Human Genetics, Edith Cowan University, Perth, Australia
(2)
Western Australian Institute for Medical Research, Perth, Australia
(3)
Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain

References

  1. Fraser A: The Gypsies. Oxford: Blackwell Publishers,. 1992Google Scholar
  2. Liegeois J-P: Roma, Gypsies, Travellers. Strasbourg: Council of Europe Press,. 1994Google Scholar
  3. Braham M: The untouchables: a survey of the Roma people in Central and Eastern Europe. Geneva: UNHCR,. 1993Google Scholar
  4. Corretger JM, Fortuny C, Botet F, Valls O: Marginalidad, grupos etnicos y salud. An Esp Pediatr. 1992, Suppl 48: 115-117.Google Scholar
  5. Binnie GAG: The health of Gypsies. Problem of caring for travellers is British, not just European. BMJ. 1998, 316: 1824-1825.View ArticlePubMedPubMed CentralGoogle Scholar
  6. Hajioff S, McKee M: The health of the Roma people: a review of the published literature. J Epidemiol Community Health. 2000, 54: 864-869. 10.1136/jech.54.11.864.View ArticlePubMedPubMed CentralGoogle Scholar
  7. Reyniers A: Gypsy populations and their movements within central and eastern Europe and towards some OECD countries. In International Migration and Labour Market Policies: Occasional Papers No1, Paris. 1995Google Scholar
  8. Romani east-west migrations: strangers in anybody's land. Cambridge Review of International Affairs. 2000, , Spring-Summer Issue.Google Scholar
  9. Fings K, Heuss H, Sparing F: From "Race Science" to the Camps. The Gypsies during the Second World War. Hartfield: University of Hetfordshire Press,. 1997Google Scholar
  10. Avcin M: Gypsy isolates in Slovenia. J Biosoc Sci. 1969, 1: 221-233.View ArticlePubMedGoogle Scholar
  11. Rex-Kiss B, Szabo L, Szabo S, Hartmann E: ABO, MN, Rh blood groups, Hp types and Hp level, Gm(1) factor investigations on the Gypsy population of Hungary. Hum Biol. 1973, 45: 41-61.PubMedGoogle Scholar
  12. Bartsocas CS, Karayanni C, Tsipouras P, Baibas E, Bouloukos A, Papadatos C: Genetic structure of the Greek gypsies. Clin Genet. 1979, 15: 5-10.View ArticlePubMedGoogle Scholar
  13. Sivakova D: Distribution of three red-cell enzyme polymorphisms (ACP, PGM1 and AK) in gypsies from Slovakia (Czechoslovakia). Ann Hum Biol. 1983, 10: 449-452.View ArticlePubMedGoogle Scholar
  14. Tauszik T, Friss A, Gyodi E, Santora Z, Takacs S, Kotvasz A, Toth AM, Horvath M, Tarjan L, Petranyi G, et al: Genetic polymorphisms of the Gypsy population in Hungary as based on studies of red blood cell antigens. Haemotologia (Budap.). 1985, 18: 205-217.Google Scholar
  15. de Pablo R, Vilches C, Moreno ME, Rementeria MC, Solis R, Kreisler M: Distribution of HLA antigens in Spanish Gypsies: a comparative study. Tissue Antigens. 1992, 40: 187-196.View ArticlePubMedGoogle Scholar
  16. Mastana SS, Papiha SS: Origin of Romany Gypsies - genetic evidence. Z Morphol Anthropol. 1992, 79: 43-51.PubMedGoogle Scholar
  17. Forrai G, Tauszik T, Auszik N, Moh T, Tunyog M, Holics C, Bankovi G, Gal I: A high incidence of PKD in a large geographic area of south-western Hungary: A medical genetic study. In Genetics of Kindey Disorders. Edited by Bartsocas C. New York: Alan R. Liss, Inc.,. 1989Google Scholar
  18. Bernasovsky I, Suchy J, Bernasovska K, Vargova T: Blood groups of Roms (Gypsies) in Czechoslovakia. Am J Phys Anthropol. 1976, 45: 277-280.View ArticlePubMedGoogle Scholar
  19. Sivakova D, Sieglova Z, Lubyova B, Novakova J: A genetic profile of a Romany (Gypsy) subethnic group from a single region in Slovakia. Gene Geogr. 1994, 8: 109-116.PubMedGoogle Scholar
  20. Guglielmino CR, Beres J: Genetic structure in relation to the history of hungarian ethnic groups. Hum Biol. 1996, 68: 335-355.PubMedGoogle Scholar
  21. Gyodi E, Tauszik T, Petranyi G, Kotvasz A, Palaffy G, Takacs , Nemak P, Hollan SR: The HLA antigen distribution in the Gipsy population in hungary. Tissue Antigens. 1981, 18: 1-12.View ArticlePubMedGoogle Scholar
  22. Harper PS, Williams EM, Sunderland E: Genetic markers in Welsh Gypsies. J Med Genet. 1977, 14: 177-182.View ArticlePubMedPubMed CentralGoogle Scholar
  23. Clarke VA: Genetic factors in some British Gypsies. In Genetic Variation in Britain. Edited by Roberts DF, Sunderland E. London: Taylor and Francis,. 1973Google Scholar
  24. Beckman L, Takman J: On the anthropology of a Swedish Gypsy population. Hereditas. 1965, 53: 272-280.View ArticlePubMedGoogle Scholar
  25. Galikova J, Vilimova M, Ferak V, Mayerova A: Haptoglobin types in Gypsies from Slovakia (Czechoslovakia). Hum Hered. 1969, 19: 480-485.View ArticlePubMedGoogle Scholar
  26. Bernasovsky I, Halko N, Biros I, Sivakova D, Jurickova J: Some genetic markers in Valachian (Olachian) Gypsies in Slovakia. Gene Geogr. 1994, 8: 99-107.PubMedGoogle Scholar
  27. Hocevar M: Die Verteilung Blutgruppen bei einem Zigeunerisolat. In Proceedings of the 10th Congress of the International Society on Blood Transfusion, Stockholm,. 1965, ii: 312-319.Google Scholar
  28. Mourant AE, Kopec AC, Domaniewska-Sobczak K: The distribution of the human blood groups and other polymorphisms. London: Oxford University Press,. 1976Google Scholar
  29. Sanger R, Race RR: The combination of blood groups in a sample of 250 people. Annals of Eugenics. 1950, 15: 77-90.View ArticleGoogle Scholar
  30. Fisher RA, Race RR: Rh gene frequencies in Britain. Nature. 1946, 157: 48-49.View ArticlePubMedGoogle Scholar
  31. Beckman LA, Takman H, Arfords KE: Distribution of blood and serum groups in a Swedish gypsy population. Acta Genetica (Basel). 1965, 15: 134-139.Google Scholar
  32. Smars G, Beckman L, Book JA: Osteogenesis imperfecta and blood groups. Acta Genet Stat Med. 1961, 11: 133-136.Google Scholar
  33. Watkin IM: The Welsh element in the South Wales coalfield. Journal of the Royal Anthropological Institute. 1965, 95: 104-114.Google Scholar
  34. Tiwari SC, Bhasin MK: The blood groups of the Brahmins and Rajputs of Garwhal. Hum Biol. 1968, 40: 386-395.PubMedGoogle Scholar
  35. Cavalli-Sforza LL, Menozzi P, Piazza A: History and geography of human genes. Princeton: Princeton University Press,. 1994Google Scholar
  36. Papiha SS, Roberts DF, Wig NN, Singh S: Red cell enzyme polymorphisms in Punjabis in north India. Am J Phys Anthropol. 1972, 37: 293-299.View ArticlePubMedGoogle Scholar
  37. Kalaydjieva L, Hallmayer J, Chandler D, Savov A, Nikolova A, Angelicheva D, King RHM, Ishpekova B, Honeyman K, Calafell F, et al: Gene mapping in Gypsies identifies a novel demyelinating neuropathy on chromosome 8q24. Nat Genet. 1996, 14: 214-217.View ArticlePubMedGoogle Scholar
  38. Kalaydjieva L, Nikolova A, Tournev I, Petrova J, Hristova A, Ishpekova B, Petkova I, Shmarov A, Stancheva S, Middleton L, et al: Hereditary motor and sensory neuropathy - Lom, a novel demyelinating neuropathy associated with deafness in Gypsies. Clinical, electrophysiological and nerve biopsy findings. Brain. 1998, 121: 399-408. 10.1093/brain/121.3.399.View ArticlePubMedGoogle Scholar
  39. Kalaydjieva L, Gresham D, Gooding R, Heather L, Baas F, de Jonge R, Blechschmidt K, Angelicheva D, Chandler D, Worsley P, et al: N-myc downstream regulated gene 1 is mutated in hereditary motor and sensory neuropathy - Lom. Am J Hum Genet. 2000, 67: 47-58. 10.1086/302978.View ArticlePubMedPubMed CentralGoogle Scholar
  40. Rogers T, Chandler D, Angelicheva D, Thomas PK, Youl B, Tournev I, Gergelcheva V, Kalaydjieva L: A novel locus for autosomal recessive peripheral neuropathy in the EGR2 region on 10q23. Am J Hum Genet. 2000, 67: 664-671. 10.1086/303053.View ArticlePubMedPubMed CentralGoogle Scholar
  41. Tournev I, Kalaydjieva L, Youl B, Ishpekova B, Guerguelcheva V, Kamenov O, Katzarova M, Kamenov Z, King RHM, Romanski K, et al: Congenital cataracts facial dysmorphism neuropathy syndrome, a novel complex genetic disease in Balkan Gypsies: clinical and electrophysiological observations. Ann Neurol. 1999, 45: 742-750. 10.1002/1531-8249(199906)45:6<742::AID-ANA8>3.3.CO;2-E.View ArticlePubMedGoogle Scholar
  42. Angelicheva D, Turnev I, Dye D, Chandler D, Thomas PK, Kalaydjieva L: Congenital cataracts facial dysmorphism neuropathy syndrome: a novel developmental disorder in Gypsies maps to 18qter. Eur J Hum Genet. 1999, 7: 560-566.View ArticlePubMedGoogle Scholar
  43. Piccolo F, Jeanpierre M, Leturcq F, Dode C, Azibi K, Toutain A, Merlini L, Jarre L, Navarro C, Krishnamoorthy R, et al: A founder mutation in the γ-sarcoglycan gene of Gypsies possibly predating their migration out of India. Hum Mol Genet. 1996, 5: 2019-2022. 10.1093/hmg/5.12.2019.View ArticlePubMedGoogle Scholar
  44. Kalaydjieva L, Perez-Lezaun A, Angelicheva D, Onengut S, Dye D, Bosshard NU, Jordanova A, Savov A, Yanakiev P, Kremensky I, et al: A founder mutation in the GK1 gene is responsible for galactokinase deficiency in Roma (Gypsies). Am J Hum Genet. 1999, 65: 1299-1307. 10.1086/302611.View ArticlePubMedPubMed CentralGoogle Scholar
  45. Plašilová M, Stoilov I, Sarfarazi M, Kadasi L, Feráková E, Ferák V: Identification of a single ancestral CYP1B1 mutation in Slovak Gypsies (Roms) affected with primary congenital glaucoma. J Med Genet. 1999, 36: 290-294.PubMedPubMed CentralGoogle Scholar
  46. Abicht A, Stucka R, Karcagi V, Vherczegfalvi A, Horváth R, Mortier W, Schara U, Ramaekers V, Jost W, Brunner J, et al: A common mutation ε1267delG in congenital myasthenic patients of Gypsy ethnic origin. Neurology. 1999, 53: 1564-1569.View ArticlePubMedGoogle Scholar
  47. Martinez-Frias ML: Analisis del riesgo que para defectos congenitos tienen differentes grupos etnicos de nuestro pais. An Esp Pediatr. 1998, 48: 395-400.PubMedGoogle Scholar
  48. Gimenez-Roldan S, Delgado G, Marin M, Villanueva A, Mateo D: Hereditary torsion dystonia in Gypsies. In Advances in Neurology. 1988, 50: 73-81.Google Scholar
  49. Martinez-Frias ML, Bermejo E: Prevalence of congenital anomaly syndromes in a Spanish Gypsy population. J Med Genet. 1992, 29: 483-486.PubMedPubMed CentralGoogle Scholar
  50. Angelicheva D, Calafell F, Savov A, Jordanova A, Kufardjieva A, Galeva I, Nedkova V, Ivanova T, Yankova P, Konstantinova D, et al: Cystic fibrosis mutations and associated haplotypes in Bulgaria: a comparative population genetic study. Hum Genet. 1997, 99: 513-520. 10.1007/s004390050398.View ArticlePubMedGoogle Scholar
  51. Kalanin J, Takarada Y, Kagawa S, Yamashita K, Ohtsuka N, Matsuoka A: Gypsy phenylketonuria: a point mutation of the phenylalanine hydroxylase gene in Gypsy families from Slovakia. Am J Med Genet. 1994, 49: 235-239.View ArticlePubMedGoogle Scholar
  52. Desviat LR, Perez B, Ugarte M: Phenylketonuria in Spanish Gypsies: prevalence of the IVS10nt546 mutation on haplotype 34. Hum Mutat. 1997, 9: 66-68. 10.1002/(SICI)1098-1004(1997)9:1<66::AID-HUMU13>3.3.CO;2-U.View ArticlePubMedGoogle Scholar
  53. Martinez G, Garcia-Lozano JR, Ribes A, Maldonado MD, Baldellou A, de Pablo R, Nunez-Roldan A: High risk of medium chain acyl-CoA dehydrogenase deficiency among Gypsies. Pediatr Res. 1998, 44: 83-84.View ArticlePubMedGoogle Scholar
  54. Plašilová M, Feráková E, Kádasi L, Poláková E, Gerinec A, Ott J, Ferák V: Linkage of autosomal recessive primary congenital glaucoma to the GLC3A locus in Roms (Gypsies) from Slovakia. Hum Hered. 1998, 48: 30-33. 10.1159/000022778.View ArticlePubMedGoogle Scholar
  55. Chandler D, Angelicheva D, Heather L, Gooding R, Gresham D, Yanakiev P, de Jonge R, Baas F, Dye D, Karagyozov L, et al: Hereditary motor and sensory neuroapthy - Lom: Refined genetic mapping in Romani (Gypsy) families from several European countries. Neuromuscul Disord. 2000, 10: 584-591. 10.1016/S0960-8966(00)00148-6.View ArticlePubMedGoogle Scholar
  56. Gitzelmann R, Hansen RG: Galactose metabolism, hereditary defects and their clinical significance. In Inherited Disorders of Carbohydrate Metabolism. Edited by Burman D, Holton JB, Pennock CA. Lancaster: MTP,. 1980Google Scholar
  57. Levy HL: Screening for galactosemia. In Inherited Disorders of Carbohydrate Metabolism. Edited by Burman D, Holton JB, Pennock CA. Lancaster: MTP,. 1980Google Scholar
  58. Dalgaard OZ: Bilateral polycystic disease of the kidneys: a follow-up of two hundred and eighty four patients and their families. Acta Med Scand. 1957, 328: 1-255.Google Scholar
  59. d'Epinay SL, Remé CH: Ausgewählte Aspekte des kongenitalen Glaukoms. Klin Mbl Augenheilk. 1977, 170: 249-259.Google Scholar
  60. Travers JP: The presentation of congenital glaucoma. Br J Ophthalmol. 1979, 56: 241-242.Google Scholar
  61. Gencikova A, Gencik A: Congenital glaucoma in Gypsies from Slovakia. Hum Hered. 1982, 32: 270-273.View ArticlePubMedGoogle Scholar
  62. Gencik A, Gencikova A, Ferak V: Population genetical aspects of primary congenital glaucoma. I. Incidence, prevalence, gene frequency and age of onset. Hum Genet. 1982, 61: 193-197.View ArticlePubMedGoogle Scholar
  63. Levy JM, Mayer G, Sacrez R, Ruff R, Francfort J-J, Rodier L: Thrombasthénie de Glanzmann-Naegeli. Etude d'un groupe éthnique à forte endogamie. Ann Pediatr (Paris). 1971, 18: 381-389.Google Scholar
  64. de la Salle C, Schwartz A, Baas M-J, Lanza F, Cazenave J-P: Detection by PCR and HphI restriction analysis of a splice site mutation at the 5' end of intron 15 of the platele GPIIb (IIb integrin) gene responsible for Glanzmann's thrombasthenia type I in Gypsies originating from the Strasbourg area. Thromb Haemost. 1995, 74: 990-991.PubMedGoogle Scholar
  65. Tournev I, Aneva L, Kamenov O, Ishpekova B, Katzarova V, Guerguelcheva V, Angelicheva D, Kalaydjieva L: Gamma-sarcoglycan deficiency in Bulgarian Gypsies. Muscle Nerve. 1998, Suppl 7: 136-Google Scholar
  66. Gresham D, Tournev I, Angelicheva D, Avena L, Kamenov O, Jeanpierre M-P, Kalaydjieva L: Limb-girdle muscular dystrophy in a Xoroxane Roma population. European Research Conferences: Inherited Disorders and Their Genes in Different European Populations, Obernai, France,. 1999Google Scholar
  67. Merlini L, Kaplan J-C, Navarro C, Barois A, Bonneau D, Brasa J, Echenne B, Gallano P, Jarre L, Jeanpierr M, et al: Homogeneous phenotype of the gypsy limb-girdle MD with the gamma-sarcoglycan C283Y mutation. Neurology. 2000, 54: 1075-1079.View ArticlePubMedGoogle Scholar
  68. Merlini L, Villanova M, Sabatelli P, Trogu A, Malandrini A, Yanakiev P, Maraldi NM, Kalaydjieva L: Hereditary motor and sensory neuropathy Lom type in an Italian Gypsy family. Neuromuscul Disord. 1998, 8: 182-185. 10.1016/S0960-8966(98)00023-6.View ArticlePubMedGoogle Scholar
  69. Butinar D, Zidar J, Leonardis L, Popovic M, Kalaydjieva L, Angelicheva D, Sininger Y, Keats B, Starr A: Hereditary auditory, vestibular, motor and sensory neuropathy in a Slovenian Roma (Gypsy) kindred. Ann Neurol. 1999, 46: 36-44. 10.1002/1531-8249(199907)46:1<36::AID-ANA7>3.0.CO;2-J.View ArticlePubMedGoogle Scholar
  70. Baethmann M, Gohlich-Ratmann G, Schröder JM, Kalaydjieva L, Voit T: HMSNL in a 13-year-old Bulgarian girl. Neuromuscul Disord. 1998, 8: 90-94. 10.1016/S0960-8966(98)00011-X.View ArticlePubMedGoogle Scholar
  71. Colomer J, Iturriaga J, Kalaydjieva L, Angelicheva D, King RHM, Thomas PK: Hereditary motor and sensory neuropathy LOM (HMSNL) in a Spanish family: clinical, electrophysiological, pathological and genetic studies. Neuromuscul Disord. 2000, 10: 578-583. 10.1016/S0960-8966(00)00149-8.View ArticlePubMedGoogle Scholar
  72. Sampson J: Notes on Professor R.L.Turner's "The position of Romani in Indo-Aryan". Journal of the Gypsy Lore Society. 1927, 6: 57-68.Google Scholar
  73. Turner RL: The position of Romani in Indo-Aryan. Journal of the Gypsy Lore Society. 1926, 5: 145-189.Google Scholar
  74. Hancock I: The emergence of Romani as a koine outside of India. In Scholarship and the Gypsy Struggle: Commitment in Romani Studies. Edited by Acton TA. Hatfield: University of Hertfordshire Press,. 2000Google Scholar
  75. Marushiakova E, Popov V: Gypsies (Roma) in Bulgaria. In Studien zur Tsiganologie und Folkloristik. Frankfurt am Main: Peter Lang,. 1997Google Scholar
  76. Hancock I: The pariah syndrome. Ann Arbor: Karoma Publishers Inc.,. 1987Google Scholar
  77. Goodman RM: Genetic disorders among the Jewish people. Baltimore: John Hopkins University Press,. 1978Google Scholar
  78. Motulsky AG: Jewish diseases and origins. Nat Genet. 1995, 9: 99-101.View ArticlePubMedGoogle Scholar
  79. de la Chapelle A: Disease gene mapping in isolated human populations: the example of Finland. J Med Genet. 1993, 30: 857-865.View ArticlePubMedPubMed CentralGoogle Scholar
  80. Peltonen L, Jalanko A, Varilo T: Molecular genetics of the Finnish disease heritage. Hum Mol Genet. 1999, 8: 1913-1923. 10.1093/hmg/8.10.1913.View ArticlePubMedGoogle Scholar
  81. Heyer E: One founder/one gene hypothesis in a new expanding population: Saguenay (Quebec, Canada). Hum Biol. 1999, 71: 99-109.PubMedGoogle Scholar
  82. Kaback M, Lim-Steele J, Dabholkar D, Brown D, Levy N, Zeiger K: Tay-Sachs disease- carrier screening, prenatal diagnosis, and the molecular era. An international perspective, 1970 to 1993. The International TSD Data Collection Network. JAMA. 1993, 270: 2307-2315. 10.1001/jama.270.19.2307.View ArticlePubMedGoogle Scholar
  83. Markel H: The stigma of disease: implications of genetic screening. Am J Med. 1992, 93: 209-215. 10.1016/0002-9343(92)90052-D.View ArticlePubMedGoogle Scholar
  84. Reynolds J, Weir BS, Cockerham CC: Estimation of the coancestry coefficient: basis for a short term genetic distance. Genetics. 1983, 105: 767-779.PubMedPubMed CentralGoogle Scholar
  85. Saitou N, Nei M: The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol. 1987, 4: 406-425.PubMedGoogle Scholar
  86. Felsenstein J: Confidence limits on phylogenies: an approach using the bootstrap. Evolution. 1985, 39: 783-791.View ArticleGoogle Scholar
  87. Felsenstein J: PHYLIP - Phylogeny Inference Package (Version 3.2). Cladistics. 1989, 5: 164-166.Google Scholar
  88. Excoffier L, Smouse PE, Quattro JM: Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. Genetics. 1992, 131: 479-491.PubMedPubMed CentralGoogle Scholar
  89. Schneider S, Kueffer J-M, Excoffier L: Arlequin ver 1.1: A software for population genetic data analysis. Genetics and Biometry Laboratory, University of Geneva, Switzerland,. 1997Google Scholar
  90. Velthuisen B, Saris JJ, de Haij S, Hayashi T, Reynolds DM, Mochizuki T, Elles R, Fossdal R, Bogdanova N, van Dijk MA, et al: A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2). Am J Hum Genet. 1997, 61: 574-555.Google Scholar
  91. Lasa A, Piccolo F, De Diego C, Jeanpierre M, Colomer J, Rodriguez MJ, Urtizberea JA, Baiget M, Kaplan J-C, Gallano P: Severe limb girdle muscular dystrophy in Spanish Gypsies: further evidence for a founder mutation in the gamma-sarcoglycan gene. Eur J Hum Genet. 1998, 6: 396-399. 10.1038/sj/ejhg/5200197.View ArticlePubMedGoogle Scholar
  92. Schlegel N, Gayet O, Morel-Kopp MC, Wyler B, Hurtaud-Roux MF, Kaplan C, MacGregor J: The molecular basis of Glanzmann thrombasthenia (GT) in a Gypsy population in France. Identification of a new mutation of the IIb gene. Blood. 1994, 84: 477a-Google Scholar
  93. Todorova A, Ashikov A, Beltcheva O, Tournev I, Kremensky I: C283Y mutation and other C-terminal nucleotide changes in the γ-sarcoglycan gene in the Bulgarian Gypsy population. Hum Mutat. 1999, 14: 40-44. 10.1002/(SICI)1098-1004(1999)14:1<40::AID-HUMU5>3.3.CO;2-I.View ArticlePubMedGoogle Scholar
  94. Blehova J, Daneslova J, Grec L, Hajeck F, Matousek M, Vojtik V: Vyskyt fenylketonurie cechach a na Morave. Cheskoslovenska Pediatrie. 1959, 14: 498-503.Google Scholar
  95. Thalhammer O, Gitzelmann R, Pantlischko M: Hypergalactosemia and galactosuria due to galactokinase deficiency in a newborn. Pediatrics. 1968, 42: 441-445.PubMedGoogle Scholar
  96. Gitzelmann R: Hereditary galactokinase deficiency. Citation Classics Current Contents. 1987, 30: 14-Google Scholar
  97. Bolgiani MP, Gallenca M, Barocelli PC: Su un caso di galattosemia da deficit di galattochinasi. Pediat Med Chir. 1984, 6: 333-336.Google Scholar
  98. Achim V: Tigani in Istoria Romaniei. In Colectia "Biblioteca enciclopedica de istorie a Romaniei". Bucuresti: Editura Enciclopedica,. 1998Google Scholar

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    1. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/content/backmatter/1471-2350-2-5-b1.pdf

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