Figure 2
From: Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function
Association between SNPs and FEV 1 in SGPP2 . This figure shows all SNPs tested for association with FEV1 in African-Americans (red markers) and European-Americans (blue markers) in Health ABC. The top graph shows the p-values for each SNP on a negative log scale. The threshold for significance, nominal P = 2 × 10-02, is shown as a line in the figure. Effect estimates (βSNP) for FEV1 (in mL) for each ancestry group are shown underneath the P-values (dotted line shows null value of 0). Effect estimates and p-values are from recessive, dominant, or additive genetic models for SNPs with p < 0.02, and from an additive genetic model for all other SNPs. Finally, the linkage disequilibrium structure of SGPP2 in the Health ABC European-American population is shown at the bottom, with darker shading representing higher R2.