Masoli M, Fabian D, Holt S, Beasley R: The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004, 59 (5): 469-478. 10.1111/j.1398-9995.2004.00526.x.
Article
PubMed
Google Scholar
Schroder NW, Maurer M: The role of innate immunity in asthma: leads and lessons from mouse models. Allergy. 2007, 62 (6): 579-590. 10.1111/j.1398-9995.2007.01386.x.
Article
CAS
PubMed
Google Scholar
Krieg AM: Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov. 2006, 5 (6): 471-484. 10.1038/nrd2059.
Article
CAS
PubMed
Google Scholar
Pasare C, Medzhitov R: Control of B-cell responses by Toll-like receptors. Nature. 2005, 438 (7066): 364-368. 10.1038/nature04267.
Article
CAS
PubMed
Google Scholar
Lazarus R, Klimecki WT, Raby BA, Vercelli D, Palmer LJ, Kwiatkowski DJ, Silverman EK, Martinez F, Weiss ST: Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. Genomics. 2003, 81 (1): 85-91. 10.1016/S0888-7543(02)00022-8.
Article
CAS
PubMed
Google Scholar
Lachheb J, Dhifallah IB, Chelbi H, Hamzaoui K, Hamzaoui A: Toll-like receptors and CD14 genes polymorphisms and susceptibility to asthma in Tunisian children. Tissue Antigens. 2008, 71 (5): 417-425. 10.1111/j.1399-0039.2008.01011.x.
Article
CAS
PubMed
Google Scholar
Carvalho A, Pasqualotto AC, Pitzurra L, Romani L, Denning DW, Rodrigues F: Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis. J Infect Dis. 2008, 197 (4): 618-621. 10.1086/526500.
Article
CAS
PubMed
Google Scholar
Novak N, Yu CF, Bussmann C, Maintz L, Peng WM, Hart J, Hagemann T, Diaz-Lacava A, Baurecht HJ, Klopp N, et al: Putative association of a TLR9 promoter polymorphism with atopic eczema. Allergy. 2007, 62 (7): 766-772. 10.1111/j.1398-9995.2007.01358.x.
Article
CAS
PubMed
Google Scholar
Hong J, Leung E, Fraser AG, Merriman TR, Vishnu P, Krissansen GW: TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort. J Gastroenterol Hepatol. 2007, 22 (11): 1760-1766. 10.1111/j.1440-1746.2006.04727.x.
Article
CAS
PubMed
Google Scholar
Torok HP, Glas J, Endres I, Tonenchi L, Teshome MY, Wetzke M, Klein W, Lohse P, Ochsenkuhn T, Folwaczny M, et al: Epistasis Between Toll-Like Receptor-9 Polymorphisms and Variants in NOD2 and IL23R Modulates Susceptibility to Crohn's Disease. Am J Gastroenterol. 2009
Google Scholar
Torok HP, Glas J, Tonenchi L, Bruennler G, Folwaczny M, Folwaczny C: Crohn's disease is associated with a toll-like receptor-9 polymorphism. Gastroenterology. 2004, 127 (1): 365-366. 10.1053/j.gastro.2004.05.051.
Article
PubMed
Google Scholar
Urry Z, Xystrakis E, Richards DF, McDonald J, Sattar Z, Cousins DJ, Corrigan CJ, Hickman E, Brown Z, Hawrylowicz CM: Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. J Clin Invest. 2009, 119 (2): 387-398.
CAS
PubMed
PubMed Central
Google Scholar
Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A: Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001, 19: 683-765. 10.1146/annurev.immunol.19.1.683.
Article
CAS
PubMed
Google Scholar
The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Childhood Asthma Management Program Research Group. Control Clin Trials. 1999, 20 (1): 91-120. 10.1016/S0197-2456(98)00044-0.
Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N Engl J Med. 2000, 343 (15): 1054-1063. 10.1056/NEJM200010123431501.
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, et al: Standardisation of spirometry. Eur Respir J. 2005, 26 (2): 319-338. 10.1183/09031936.05.00034805.
Article
CAS
PubMed
Google Scholar
Hollis BW, Kamerud JQ, Selvaag SR, Lorenz JD, Napoli JL: Determination of vitamin D status by radioimmunoassay with an 125I-labeled tracer. Clin Chem. 1993, 39 (3): 529-533.
CAS
PubMed
Google Scholar
Hollis BW, Napoli JL: Improved radioimmunoassay for vitamin D and its use in assessing vitamin D status. Clin Chem. 1985, 31 (11): 1815-1819.
CAS
PubMed
Google Scholar
Hunninghake GM, Soto-Quiros ME, Avila L, Ly NP, Liang C, Sylvia JS, Klanderman BJ, Silverman EK, Celedon JC: Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica. J Allergy Clin Immunol. 2007, 119 (3): 654-661. 10.1016/j.jaci.2006.12.609.
Article
PubMed
Google Scholar
Pearce N, Ait-Khaled N, Beasley R, Mallol J, Keil U, Mitchell E, Robertson C: Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax. 2007, 62 (9): 758-766. 10.1136/thx.2006.070169.
Article
PubMed
PubMed Central
Google Scholar
Blumenthal MN, Banks-Schlegel S, Bleecker ER, Marsh DG, Ober C: Collaborative studies on the genetics of asthma--National Heart, Lung and Blood Institute. Clin Exp Allergy. 1995, 25 (Suppl 2): 29-32. 10.1111/j.1365-2222.1995.tb00416.x.
Article
PubMed
Google Scholar
Himes BE, Dai Y, Kohane IS, Weiss ST, Ramoni MF: Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records. J Am Med Inform Assoc. 2009, 16 (3): 371-379. 10.1197/jamia.M2846.
Article
PubMed
PubMed Central
Google Scholar
Zeng QT, Goryachev S, Weiss S, Sordo M, Murphy SN, Lazarus R: Extracting principal diagnosis, co-morbidity and smoking status for asthma research: evaluation of a natural language processing system. BMC Med Inform Decis Mak. 2006, 6: 30-10.1186/1472-6947-6-30.
Article
PubMed
PubMed Central
Google Scholar
Pritchard JK, Rosenberg NA: Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet. 1999, 65 (1): 220-228. 10.1086/302449.
Article
CAS
PubMed
PubMed Central
Google Scholar
Price AL, Butler J, Patterson N, Capelli C, Pascali VL, Scarnicci F, Ruiz-Linares A, Groop L, Saetta AA, Korkolopoulou P, et al: Discerning the ancestry of European Americans in genetic association studies. PLoS Genet. 2008, 4 (1): e236-10.1371/journal.pgen.0030236.
Article
PubMed
PubMed Central
Google Scholar
Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D: Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006, 38 (8): 904-909. 10.1038/ng1847.
Article
CAS
PubMed
Google Scholar
Chu JH, Weiss ST, Carey VJ, Raby BA: A graphical model approach for inferring large-scale networks integrating gene expression and genetic polymorphism. BMC Syst Biol. 2009, 3: 55-10.1186/1752-0509-3-55.
Article
PubMed
PubMed Central
Google Scholar
Lange C, DeMeo D, Silverman EK, Weiss ST, Laird NM: PBAT: tools for family-based association studies. Am J Hum Genet. 2004, 74 (2): 367-369. 10.1086/381563.
Article
PubMed
PubMed Central
Google Scholar
Lake SL, Laird NM: Tests of gene-environment interaction for case-parent triads with general environmental exposures. Ann Hum Genet. 2004, 68 (Pt 1): 55-64. 10.1046/j.1529-8817.2003.00073.x.
Article
CAS
PubMed
Google Scholar
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, et al: PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007, 81 (3): 559-575. 10.1086/519795.
Article
CAS
PubMed
PubMed Central
Google Scholar
Himes BE, Hunninghake GM, Baurley JW, Rafaels NM, Sleiman P, Strachan DP, Wilk JB, Willis-Owen SA, Klanderman B, Lasky-Su J, et al: Genome-wide association analysis identifies PDE4 D as an asthma-susceptibility gene. Am J Hum Genet. 2009, 84 (5): 581-593. 10.1016/j.ajhg.2009.04.006.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fisher RAS: Statistical Methods for Research Workers. 1970, New York: Hafner Press, 14
Google Scholar
Won S, Morris N, Lu Q, Elston RC: Choosing an optimal method to combine P-values. Stat Med. 2009, 28 (11): 1537-1553. 10.1002/sim.3569.
Article
PubMed
PubMed Central
Google Scholar
Baron RM, Carvajal IM, Liu X, Okabe RO, Fredenburgh LE, Macias AA, Chen YH, Ejima K, Layne MD, Perrella MA: Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia. J Immunol. 2004, 173 (6): 4147-4153.
Article
CAS
PubMed
Google Scholar
Dickie LJ, Church LD, Coulthard LR, Mathews RJ, Emery P, McDermott MF: Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes. Rheumatology (Oxford). 2010
Google Scholar
Lammers KM, Ouburg S, Morre SA, Crusius JB, Gionchett P, Rizzello F, Morselli C, Caramelli E, Conte R, Poggioli G, et al: Combined carriership of TLR9-1237C and CD14-260T alleles enhances the risk of developing chronic relapsing pouchitis. World J Gastroenterol. 2005, 11 (46): 7323-7329.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mollaki V, Georgiadis T, Tassidou A, Ioannou M, Daniil Z, Koutsokera A, Papathanassiou AA, Zintzaras E, Vassilopoulos G: Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate-gene association study. J Hum Genet. 2009
Google Scholar
Velez DR, Wejse C, Stryjewski ME, Abbate E, Hulme WF, Myers JL, Estevan R, Patillo SG, Olesen R, Tacconelli A, et al: Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. Hum Genet. 2009
Google Scholar
Pine SO, McElrath MJ, Bochud PY: Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individuals. AIDS. 2009, 23 (18): 2387-2395. 10.1097/QAD.0b013e328330b489.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ramaprakash H, Ito T, Standiford TJ, Kunkel SL, Hogaboam CM: Toll-like receptor 9 modulates immune responses to Aspergillus fumigatus conidia in immunodeficient and allergic mice. Infect Immun. 2009, 77 (1): 108-119. 10.1128/IAI.00998-08.
Article
CAS
PubMed
Google Scholar
Creticos PS, Schroeder JT, Hamilton RG, Balcer-Whaley SL, Khattignavong AP, Lindblad R, Li H, Coffman R, Seyfert V, Eiden JJ, et al: Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med. 2006, 355 (14): 1445-1455. 10.1056/NEJMoa052916.
Article
CAS
PubMed
Google Scholar
Kline JN, Krieg AM: Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy. Drug News Perspect. 2008, 21 (8): 434-439.
CAS
PubMed
Google Scholar
Kanzler H, Barrat FJ, Hessel EM, Coffman RL: Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med. 2007, 13 (5): 552-559. 10.1038/nm1589.
Article
CAS
PubMed
Google Scholar
Kline JN, Krieg AM, Waldschmidt TJ, Ballas ZK, Jain V, Businga TR: CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma. J Allergy Clin Immunol. 1999, 104 (6): 1258-1264. 10.1016/S0091-6749(99)70022-9.
Article
CAS
PubMed
Google Scholar
Tversky JR, Bieneman AP, Chichester KL, Hamilton RG, Schroeder JT: Subcutaneous allergen immunotherapy restores human dendritic cell innate immune function. Clin Exp Allergy. 40 (1): 94-102.
Constabel H, Stankov MV, Hartwig C, Tschernig T, Behrens GM: Impaired lung dendritic cell migration and T cell stimulation induced by immunostimulatory oligonucleotides contribute to reduced allergic airway inflammation. J Immunol. 2009, 183 (5): 3443-3453. 10.4049/jimmunol.0804223.
Article
CAS
PubMed
Google Scholar
Kline JN: Eat dirt: CpG DNA and immunomodulation of asthma. Proc Am Thorac Soc. 2007, 4 (3): 283-288. 10.1513/pats.200701-019AW.
Article
CAS
PubMed
PubMed Central
Google Scholar
Berghofer B, Frommer T, Konig IR, Ziegler A, Chakraborty T, Bein G, Hackstein H: Common human Toll-like receptor 9 polymorphisms and haplotypes: association with atopy and functional relevance. Clin Exp Allergy. 2005, 35 (9): 1147-1154. 10.1111/j.1365-2222.2005.02325.x.
Article
CAS
PubMed
Google Scholar
Noguchi E, Nishimura F, Fukai H, Kim J, Ichikawa K, Shibasaki M, Arinami T: An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. Clin Exp Allergy. 2004, 34 (2): 177-183. 10.1111/j.1365-2222.2004.01839.x.
Article
CAS
PubMed
Google Scholar
Daley D, Lemire M, Akhabir L, Chan-Yeung M, He JQ, McDonald T, Sandford A, Stefanowicz D, Tripp B, Zamar D, et al: Analyses of associations with asthma in four asthma population samples from Canada and Australia. Hum Genet. 2009, 125 (4): 445-459. 10.1007/s00439-009-0643-8.
Article
PubMed
Google Scholar
Smit LA, Siroux V, Bouzigon E, Oryszczyn MP, Lathrop M, Demenais F, Kauffmann F: CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Am J Respir Crit Care Med. 2009, 179 (5): 363-368. 10.1164/rccm.200810-1533OC.
Article
CAS
PubMed
Google Scholar
De Jager PL, Richardson A, Vyse TJ, Rioux JD: Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus. Arthritis Rheum. 2006, 54 (4): 1279-1282. 10.1002/art.21755.
Article
CAS
PubMed
Google Scholar
Demirci FY, Manzi S, Ramsey-Goldman R, Kenney M, Shaw PS, Dunlop-Thomas CM, Kao AH, Rhew EY, Bontempo F, Kammerer C, et al: Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus. J Rheumatol. 2007, 34 (8): 1708-1711.
CAS
PubMed
Google Scholar
Hur JW, Shin HD, Park BL, Kim LH, Kim SY, Bae SC: Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus. Tissue Antigens. 2005, 65 (3): 266-270. 10.1111/j.1399-0039.2005.00374.x.
Article
CAS
PubMed
Google Scholar
Ito A, Ota M, Katsuyama Y, Inoko H, Ohno S, Mizuki N: Lack of association of Toll-like receptor 9 gene polymorphism with Behcet's disease in Japanese patients. Tissue Antigens. 2007, 70 (5): 423-426. 10.1111/j.1399-0039.2007.00924.x.
Article
CAS
PubMed
Google Scholar
Ben Dhifallah I, Lachheb J, Houman H, Hamzaoui K: Toll-like-receptor gene polymorphisms in a Tunisian population with Behcet's disease. Clin Exp Rheumatol. 2009, 27 (2 Suppl 53): S58-62.
CAS
PubMed
Google Scholar
Hamann L, Glaeser C, Hamprecht A, Gross M, Gomma A, Schumann RR: Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis. Clin Chim Acta. 2006, 364 (1-2): 303-307. 10.1016/j.cca.2005.07.017.
Article
CAS
PubMed
Google Scholar
Ng MT, van 't Hof R, Crockett JC, Hope ME, Berry S, Thomson J, McLean MH, McColl KE, El-Omar EM, Hold GL: Increase in NF-{kappa}B binding affinity of the C allelic variant of the Toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori induced gastric disease. Infect Immun. 2009
Google Scholar