Figure 2
From: Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles
Expected equilibrium frequency of the disease phenotype caused by an overdominant antagonistically pleiotropic allele. Equilibrium frequencies for homozygous disadvantages, Sdel, of 100% (completely lethal or always causing sterility), 50%, 25% and 10% are shown for a range of heterozygous advantageous effects ranging from 0% (no advantage) to 25% (a moderate, but potentially unrecognized, advantage). Note the Log10 scale on the Y-axis.