Table 5 Prevalence of different cancer localizations among 1st and 2nd degree relatives of probands who were BRCA1 c.4034delA and c.5266dupC mutation carriers (in % of all the reported cancer cases in each group)
From: Genotype-phenotype correlations among BRCA14153delA and 5382insC mutation carriers from Latvia
Cancer site | c.4034delA | c.5266dupC | 95% CI | P-value |
|---|---|---|---|---|
Breast | 19.0% | 34.0% | 7.16 to 22.84 | 0.0002 |
Ovary | 19.0% | 8.0% | 4.66 to 17.34 | 0. 0003 |
Other gynaecological cancers* | 16.0% | 8.0% | 1.94 to 14.06 | 0.006 |
Colon and rectum | 2.6% | 3.1% | -2.75 to 3.75 | n.s |
Pancreas | 1.3% | 1.3% | -2.35 to 2.35 | n.s |
Prostate | 1.7% | 2.4% | -2.12 to 3.52 | n.s |
Stomach | 11.3% | 9.6% | -4.00 to 7.40 | n.s |
Lung | 6.5% | 2.7% | -0.28 to 7.88 | 0.059 |
Total amount of relatives reported as having cancer | 230 | 290 | Â | Â |