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Table 5 Prevalence of different cancer localizations among 1st and 2nd degree relatives of probands who were BRCA1 c.4034delA and c.5266dupC mutation carriers (in % of all the reported cancer cases in each group)

From: Genotype-phenotype correlations among BRCA14153delA and 5382insC mutation carriers from Latvia

Cancer site c.4034delA c.5266dupC 95% CI P-value
Breast 19.0% 34.0% 7.16 to 22.84 0.0002
Ovary 19.0% 8.0% 4.66 to 17.34 0. 0003
Other gynaecological cancers* 16.0% 8.0% 1.94 to 14.06 0.006
Colon and rectum 2.6% 3.1% -2.75 to 3.75 n.s
Pancreas 1.3% 1.3% -2.35 to 2.35 n.s
Prostate 1.7% 2.4% -2.12 to 3.52 n.s
Stomach 11.3% 9.6% -4.00 to 7.40 n.s
Lung 6.5% 2.7% -0.28 to 7.88 0.059
Total amount of relatives reported as having cancer 230 290   
  1. * - Other gynaecological cancers include ovarian, uterine and cervical cancer cases when exact localization of cancer was unknown.
  2. n.s. - non-significant