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Table 2 Association with type 2 diabetes in the Chinese Han population.

From: Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in Type 2 Diabetes in a Chinese population

Chr SNPs Genes Genotypes distribution a Genotypic Pnominal Minor/Major Alleles RAF Odd ratio (95%CI) Allelic Pnominal c Allelic Ppermuted d
    Patients bb/Bb/BB Controls Bb/Bb/BB    Patients Controls    
9 rs10811661 CDKN2A/B 145:514:343 191:514:279 0.002 C/T 0.60 0.55 1.22(1.06-1.41) 0.005 0.005
8 rs13266634 SLC30A8 149:457:386 179:487:327 0.01 T/C 0.62 0.57 1.19(1.04-1.37) 0.009 0.009
4 rs6446482 WFS1 0:71:914 2:91:880 0.06 C/G 0.96 0.95 1.39(0.98-1.92) 0.06 0.06
10 rs5015480 HHEX 43:336:627 31:290:668 0.04 C/T 0.21 0.18 1.20(1.01-1.42) 0.03 0.03
17 rs7501939 TCF2 89:443:460 73:378:490 0.04 T/C 0.31 0.28 1.12(0.97-1.30) 0.12 0.12
6 rs10946398 CDKAL1 240:472:286 170:498:323 0.0006 C/A 0.48 0.42 1.27(1.11-1.45) 0.0006 0.0008
16 rs8050136 FTO 17:229:761 10:195:790 0.08 A/C 0.13 0.11 1.24(1.01-1.52) 0.041 0.046
3 rs4402960 IGF2BP2 76:418:503 53:356:571 0.001 T/G 0.29 0.24 1.26(1.08-1.47) 0.003 0.003
11 rs2237892 KCNQ1 69:396:525 107:437:415 1.23 × 10-5 T/C 0.73 0.66 1.37(1.19-1.69) 2.47 × 10-5 1.0 × 10-4
  1. a. Genotype distributions are shown as the counts of three genotypes (bb, Bb, and BB). b, Minor allele; B, Major allele. RAF, Risk allele; OR, Risk allele-specific odds ratios calculated by logistic regression analysis. c. Adjusted for age, gender, and BMI. d. Permutation for 10,000 times. Bold indicates the risk allele.