This article has Open Peer Review reports available.
Health status in patients at risk of inherited arrhythmias and sudden unexpected death compared to the general population
© Hamang et al; licensee BioMed Central Ltd. 2010
Received: 6 July 2009
Accepted: 17 February 2010
Published: 17 February 2010
The possibilities in the molecular genetics of long QT syndrome (LQTS) and hypertrophic cardiomyopathy (HCM) has made family screening, with diagnostic and predictive genetic testing part of the health care offer in genetic counselling of inherited arrhythmias, potentially affecting the subjective health among these individuals. The study compared health status among patients at risk of arrhythmia because of family history or clinical diagnosis of LQTS and HCM with reference health status scores of the general population.
In the period 2005-2007, 127 patients (mean age 45 years, 53.5% women), with a family history of arrhythmia (n = 95) or a clinical diagnosis of LQTS (n = 12) or HCM (n = 19) referred for genetic counselling at the medical genetic departments in Norway filled in a questionnaire (Short Form Health Survey SF-36) measuring health status on eight domains. The patient SF-36 scores were compared to expected scores of the general population by t-test, and the relationship between the socio-demographic variables, clinical status, and SF-36 domains were analysed by multiple linear regression.
The total sample reported significant lower SF-36 score as compared to the general population scores for the domain of general health (mean difference -7.3 (<0.001). When analysing the sample in subgroups according to clinical status, the general health was still significant lower for the group of family risk and in the group of HCM. In addition the physical functioning, role physical, vitality and role emotional domains were reduced for the latter group. In general, employment, higher education and being referred to genetic counselling through a family member were associated with better scores on the health status domains.
Having a genetic risk of arrhythmia affects general health significantly. In addition, patients with a clinical diagnosis of HCM demonstrate a significantly poorer health in both physical and mental domains.
Patients with long QT syndrome (LQTS) and hypertrophic cardiomyopathy (HCM) have a genetically based increased risk for serious arrhythmias. Both patients and family members therefore live with the threat of a premature sudden death. This threat applies especially to children and teenagers, but can also affect adults [1, 2]. The advances in gene technology have made it possible to offer genetic testing, and at risk individuals and their close relatives have the opportunity to receive genetic counselling.
The penetrance (likelihood for actually developing the disease) is varying, which leads to uncertainty of ever experiencing clinical symptoms of the disease. The manifestations of symptoms can range from asymptomatic to sudden death, but there can be a lot of variation between individuals and families. The two diseases are structurally and functionally different from each other. LQTS is an ion channel disease leading to a prolonged QT interval with an increased propensity to ventricular tachycardia manifesting as torsade de pointes . HCM is defined by the presence of increased ventricular wall thickness or mass, having ruled out hypertension and valve disease . However, being genetic disorders causing arrhythmias they still have a lot in common in the genetic counselling setting, where topics like inheritance patterns, symptoms, management and prevention are being addressed according to guidelines .
Events and issues such as experiencing syncope, surviving life-threatening arrhythmias and living with an implantable cardioverter-defibrillator (ICD), have previously been shown to have an effect on health status [6–8]. It is also well documented that uncertainty about one's health can be very distressing [9, 10], as well as the uncertainty regarding your children's health [11, 12].
Living with the genetic risk of arrhythmia and possible sudden death may therefore affect health status of the patient group referred to genetic counselling. However, the knowledge of the health status of the patients coming to genetic counselling because of a risk of inherited arrhythmias is limited. Previous studies have mainly focused on children at genetic risk and their parents' higher distress levels as a reaction to that [13–15].
In the adult patient population a qualitative study of living with LQTS reported that these patients reported worries and limitations in daily life, but also here their main concern was for their children or grandchildren .
In adult HCM patients, living with HCM has been reported to be associated with decreased levels of self reported health status compared to the general population , and one study also reported problems for the patients to adjust to the diagnosis .
In Health research, the traditional outcomes mortality and morbidity have been supplemented with subjective accounts of health in patient groups of various diseases . In general, health status is measured by instruments based on a multidimensional model of health, such as the Short Form Health Survey [SF-36] which is used in the present study. In SF-36, eight domains are constructed from the Medical Outcomes Study (MOS) (Boston, USA) which is relevant to functional status and well-being, and that can directly be affected by disease and treatment .
The patients coming to genetic counselling consist of high risk individuals with the potential to develop an arrhythmia. The arrhythmia risk may be present either because of a family history of arrhythmia or that individuals have a clinical diagnosis such as long QT syndrome. Similarly the HCM group consists of persons with a possible inherited risk not yet diagnosed and patients with the clinical condition.
Because there is limited systematic information about how the increased genetic risk affects the health status of the heart patients with LQTS or HCM, as well as their family members, we investigated the health status in a Norwegian sample of patients at risk of inherited arrhythmia prior to the genetic counselling session. Specifically, our research questions were; (1) Is there a relationship between living with genetic risk of inherited arrhythmia and health status vulnerability? (2) What is the relationship between socio-demographic variables, clinical status and health status domains among the patients at risk of arrhythmia coming to genetic counselling?
The arrhythmia risk patients
One hundred and seventy-three patients were asked to participate in the study. Of these 39 (22.5%) did not consent to participate and 7 (5.2%) did not return the questionnaire, leaving 127 (73.4%) patients included in the study.
The general population
SF-36 expected scores were calculated based on the normative data from the general Norwegian population aged 19-80 that were randomly drawn from the Norwegian Population Register (n = 3500). In total 2323 (67%) responded .
Participants filled in a questionnaire measuring health status and socio-demographic variables, whereas their clinical status was obtained from the medical records. Information about the study and a consent form was mailed to the patient together with the questionnaire 2-4 weeks before the genetic counselling. The participants received one reminder. The study was approved by the Regional committee for medical research ethics in Western Norway in September 2004.
Short Form-36 Health Survey (SF-36) is a self-report questionnaire that measures health status domains (0 = worst health state. 100 = best health state) on eight sub-scales; where physical functioning (PF), role limitation-physical (RP), bodily pain (BP) and general health (GH) are mainly considered physical health domains and vitality (VT), social functioning (SF), role limitation-emotional (RE) and mental health (MH) are considered mental health domains. The general health and vitality domains have both physical and mental aspects in their construct. An additional point reports changes in health over the last year. The questionnaire is generic and multidimensional and it is suitable for administration to large populations and to subgroups such as patients. Its purpose is to be a measure of health status or health outcome in cross-sectional and longitudinal studies. The SF-36 has been shown to be a reliable and valid measure across studies all over the world and the Norwegian version exhibits satisfactory psychometric properties [21–24].
Socio-demographic variables and clinical status
The socio-demographic variables age, sex, and marital status, children, employment and education status, heart-disease in the family, family history of sudden death and/or genetic testing, and referral by physician/self referral through family member were obtained from the self-report questionnaire. The clinical status was collected from the patients' medical record and defined as having a family risk of arrhythmia or having a clinical diagnosis of either LQTS or HCM.
Descriptive analyses were performed for socio-demographic variables, clinical status and the health status domains of SF-36. Descriptive statistics for SF-36 are given as mean, standard deviation (SD) and number of participants. SF-36 expected scores were calculated based on the normative data from the general Norwegian population aged 19-80 years that were randomly drawn from the Norwegian Population Register (n = 3500) . SF-36 expected scores for each of the respondents were calculated for all health status domains, controlling for age and sex. Bivariate analyses were performed using paired samples t-tests  when comparing health status in the different groups with expected scores. Non-parametric tests were considered for analyzing the two smaller subgroups, but gave the same results with regard to statistical significance as the parametric tests. It was therefore decided to present the results with the parametric analysis, reporting mean differences and p-values.
When measuring the impact of clinical status on levels of health status, one-way analysis of variance (anova) with post hoc comparisons, using the Tukey method to correct for multiple testing was used.
Multiple linear regression analyses were performed on the total arrhythmia-risk group to assess the impact of the socio-demographic variables and clinical status on the different health domains of SF-36. Models were reported as unstandardised regression coefficients (β) with standard error, p-values and determination coefficients (R 2), adjusted. From a fully adjusted model with all socio-demographic variables and clinical status entered, a backward stepwise elimination of predictors were performed to achieve a final model with variables fulfilling the inclusion criteria with p ≤ 0.05 and excluded with p ≥ 0.1 All other tests were two-tailed at the 5% significance level. Data were analyzed using SPSS version 15.0.
Socio-demographic variables and clinical status of the 127 arrhythmia risk patients coming to genetic counselling
n = 127
29 or less:
70 or more:
Heart-disease in family
Long QT syndrome (LQTS)
Hypertrophic cardiomyopathy (HCM)
Sudden Death Occurred in Family
Genetic Testing Conducted in
Self referred through family
Clinical diagnosis of LQTS
Clinical diagnosis of HCM
Comparisons with the expected scores of the general population
SF-36 Health status scores among patients at risk of inherited arrhythmias compared to the expected scores of the general population*
SF-36 Health status domains
Comparisons between the groups according to clinical status
Differences between groups according to clinical status*
SF-36 Health status domains
F-test statistic (p-value)
F 2,121 = 11.3
F 2,125 = 7.8
F 2,126 = 5,5
F 2,126 = 7.5
F 2,125 = 2.7
F 2,126 = 2.2
F 2,125 = 2.3
F 2,126 = 0.1
The relationship between socio-demographic variables and health status domains
Multiple linear regression analysis assessing the relationship between socio-demographic variables, clinical status and the SF-36 health status domains among the arrhythmia risk patients*
SF-36 Health status domains
Socio-demographic variables and clinical status
Heart disease in family
Genetic testing in family
Sudden death in the family
Heart disease in the family
The present study demonstrates reduced health status in the SF-36 domain of general health in the arrhythmia-risk patients. The general health domain was reported significantly lower than the general population with the largest mean difference. In general, employment, higher education and being referred to genetic counselling through a family member were associated with better scores on the health status domains.
The general health domain deals with a personal evaluation of both physical and mental health, including current health, health outlook, and resistance to illness. In the present study, the general health domain was reduced among patients at genetic risk of arrhythmia, even if the other physical health domains were indifferent or even better than the expected scores from the general population. The mental health domains were less than the reference scores, but none of them reached statistical significance. Even if the finding may seem inconsistent, considering what these patients are up against, it might not be surprising. Living with and having knowledge about genetic risk of sudden death in the family can initiate genetic testing and health preventive behaviours, but one can also imagine that it will have an effect on how you perceive your health and health outlook.
According to a psychological framework for analysing risk of disease, the risk can be defined in terms of probability and effect . The probability part of the risk concept is the likelihood of some specific negative event will occur as a result of the possible genetic vulnerability. For most patients in our study there is a high probability for heart disease, since the genetic vulnerability for heart disease is already known among first degree family members. The probability for having inherited mutation associated with heart disease is 50% (autosomal dominant inheritance), although, the penetrance for actually developing the disease as well as the intra-familial expression of the disease are varying. The effect side of the risk concept is the severity or consequence of the event. In a proportion of cases the event is very serious and even fatal in this patient population. With this in mind it can be the patients' relation to living with this risk that explain why they rate their general health poorly. It has been shown that uncertainty about survival can decrease the perception of general health [8, 9], and Loge et al discusses their similar finding among Hodgkin's disease survivors, that it may reflect having lived with a potentially fatal disease . Our participants are currently living with the risk of a potentially fatal disease, but this does not seem to influence the other health domains.
In other patient groups coming to genetic counselling, there have also been similar findings. In a study of women with high risk for breast cancer due to family history, subjects reported significant lower levels of health status for domains related to mental health and for general health compared to normative data, but similar levels on domains related to physical health .
There were also differences in health status between the subgroups and the expected scores of the general population, and differences between the groups according to clinical status. Patients with HCM had significantly reduced scores on physical health status domains compared to both the expected scores of the general population, the patients with LQTS and the family risk group, and reduced scores of the domains of vitality and role emotional compared to the general population. This is comparable with results from a study of health related quality of life and psychological wellbeing in patients with HCM, where the analysis of the SF-36 indicated limitations in both the physical and mental health domains . In our study the LQTS group also demonstrated lower scores on most of the health domains but none were significant. This can be due to the nature of the diseases, where HCM will have more manifestations of physical symptoms that are more prone to affect especially physical health domains, whereas having a clinical diagnosis of LQTS or family risk may cause more worries and distress because there might be more uncertainties around symptoms, diagnosis and management of the disease, potentially affecting more psychological measures as previous research have shown [13, 15, 29–31].
In the present study, women scored significantly lower than men on the domains of bodily pain, vitality and mental health, domains that primarily measure well-being, whereas not for the domains that measures disability, such as physical functioning, role-physical, social functioning and role-emotional. One explanation of this might be that it is different for men and women to live with the risk of uncertainty. It has been previously shown that impact of uncertainty associated with children's chronic health condition can have a relationship with mothers mental and physical health, while uncertainty does not affect fathers' health in the same way. In the normative data of the general Norwegian population all of the physical health status domains had a strong relationship with age, and in three out of four physical health domains women scored lower than men .
Being employed had a positive relationship to both physical and mental health domains in our study, which is in line with epidemiological research conducted in Norway that found better perceived health status in employed, as compared to unemployed and disability benefit recipients . Lower education status predicted also lower health status as reported from the normative data of the Norwegian general population .
In a study of the psychological impact of risk for long QT syndrome, parents of carrier children reported high levels of distress. The distress was predicted by lower education status along with previous history of distress in person, knowledge of the disease for a longer time period, sudden death in the family, and unsatisfied with the disease-information . In the present study reduced scores on the mental health domain is best predicted by being female, having children, lower education status and referral by physician, while experience of sudden death in the family did not have a significant relationship to mental health.
Implications for genetic counselling practice
The main aim of the genetic counselling is to help people to understand and adapt to the medical, psychological, and familial implications of genetic contributions to disease. Therefore, it is important to have knowledge about the health status of these individuals coming to genetic counselling in order to be able to interpret, educate and counsel .
In the present study it was found that the socio-demographic variable influencing the health domains the most was how the patient was referred to genetic counselling. Being referred by a physician consistently showed a negative relationship to all health status domains. Other research has revealed that the patients experience a lack of knowledge and understanding concerning inherited arrhythmias among health-care providers [15, 17, 18, 34], which previously have been described to have the potential of creating uncertainty, lead to misinformation and wrong treatment advice . Being referred by a physician might influence the patient's perception and understanding of the content of information that is received in this setting compared to when patients are self-referred through a family member. Although it might also be that the patients rate their condition more seriously if the health care provider refers them to genetic counselling, expecting it is more serious then, or that the patients referred by the physician do have actual symptoms of disease. Regardless, being referred to genetic counselling will provide the possibility of getting the information necessary to be able to adapt to and understand the situation, which according to previous research  can be key predictors to an improved general health status in inherited arrhythmias.
The design of this study shares the limitations that all cross-sectional designs have regarding control, causality and generalisability. Our sample size was relatively small; however the data was collected at three different hospitals in three different health regions of Norway to reduce possible influence of community characteristics.
An important issue in discussing the findings in the present study are whether the research sample is representative of a greater population and what kind of biases might influence the results. Ideally we would like to generalize the finding in our study to all subjects undergoing genetic counselling for LQTS and HCM. The rate of decliners in the study was fairly high (26.6%). The Regional Committee for Medical and Health Research Ethics did not permit publication of data related to information for individuals who did not consent for research. Therefore, it was not possible to compare respondents to non-respondents. We cannot rule out the possibility that the decliners are different than the respondents. More health problems among non-responders , could be an alternative explanation for the somewhat better health scores in the present study, than what could have been expected.
The arrhythmia risk groups were different from each other with the distribution of some of the socio-demographic variables, but even if this mostly was controlled for in the analysis, there can be other variables that influence also. In the genetic counselling setting it is however interesting to analyse the groups together since it is not so much the clinical manifestations that are central to the research questions, but more the attempt to elucidate a major unmeasured component of overall health risk, the extent to which knowledge gained about the potential harm associated with the risk of disease affects the outcome of the subjective health status of the patients coming to genetic counselling. We were able in this study to explain considerable variance in the dependent variables with the socio-demographic variables and clinical status. However some variance in health status is yet to be explained, such as the influence of psychosocial variables.
In conclusion, living with genetic risk of arrhythmia and possible sudden death is most likely related to health status vulnerability. In general, persons at genetic risk of arrhythmia perceive their current health; health outlook and resistance to illness to be lower than the general population, and for persons with HCM, physical health and emotional problems can in addition limit and interfere with work or daily activities. Lower health status reported on general health suggests that the arrhythmia-risk patients indeed is a special patient-group, a finding adding to the knowledge that this patient group can benefit particularly from genetic counselling. Prospective studies might give more insights to the effect of genetic counselling.
The authors thank all patients who participated in the study. We also acknowledge all helpful assistance from the Heart Foundation and the Genetic Departments in Oslo, Bergen and Trondheim. The project was supported financially by Western Norway Regional Health Authority and the University of Bergen.
- Sauer AJ, Moss AJ, McNitt S, Peterson DR, Zareba W, Robinson JL, Qi M, Goldenberg I, Hobbs JB, Ackerman MJ, Benhorin J, Hall WJ, Kaufman ES, Locati EH, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent GM, Zhang L: Long QT syndrome in adults. J Am Coll Cardiol. 2007, 49: 329-337. 10.1016/j.jacc.2006.08.057.View ArticlePubMedGoogle Scholar
- Elliott PM, Poloniecki J, Dickie S, Sharma S, Monserrat L, Varnava A, Mahon NG, McKenna WJ: Sudden death in hypertrophic cardiomyopathy: identification of high risk patients. J Am Coll Cardiol. 2000, 36: 2212-2218. 10.1016/S0735-1097(00)01003-2.View ArticlePubMedGoogle Scholar
- Khan IA: Long QT syndrome: diagnosis and management. Am Heart J. 2002, 143: 7-14. 10.1067/mhj.2002.120295.View ArticlePubMedGoogle Scholar
- Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P, Dubourg O, Kuhl U, Maisch B, McKenna WJ, Monserrat L, Pankuweit S, Rapezzi C, Seferovic P, Tavazzi L, Keren A: Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2008, 29: 270-276. 10.1093/eurheartj/ehm342.View ArticlePubMedGoogle Scholar
- Zipes DP, Camm AJ, Borggrefe M, Buxton AE, Chaitman B, Fromer M, Gregoratos G, Klein G, Moss AJ, Myerburg RJ, Priori SG, Quinones MA, Roden DM, Silka MJ, Tracy C, Smith SC, Jacobs AK, Adams CD, Antman EM, Anderson JL, Hunt SA, Halperin JL, Nishimura R, Ornato JP, Page RL, Riegel B, Blanc JJ, Budaj A, Dean V, Deckers JW, Despres C, Dickstein K, Lekakis J, McGregor K, Metra M, Morais J, Osterspey A, Tamargo JL, Zamorano JL: ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (writing committee to develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation. 2006, 114: e385-e484. 10.1161/CIRCULATIONAHA.106.178233.View ArticlePubMedGoogle Scholar
- van Dijk N, Sprangers MA, Colman N, Boer KR, Wieling W, Linzer M: Clinical factors associated with quality of life in patients with transient loss of consciousness. J Cardiovasc Electrophysiol. 2006, 17: 998-1003. 10.1111/j.1540-8167.2006.00533.x.View ArticlePubMedGoogle Scholar
- Carroll DL, Hamilton GA: Quality of life in implanted cardioverter defibrillator recipients: the impact of a device shock. Heart Lung. 2005, 34: 169-178. 10.1016/j.hrtlng.2004.10.002.View ArticlePubMedGoogle Scholar
- Carroll DL, Hamilton GA, McGovern BA: Changes in health status and quality of life and the impact of uncertainty in patients who survive life-threatening arrhythmias. Heart Lung. 1999, 28: 251-260. 10.1016/S0147-9563(99)70071-3.View ArticlePubMedGoogle Scholar
- Padilla GV, Mishel MH, Grant MM: Uncertainty, appraisal and quality of life. Qual Life Res. 1992, 1: 155-165. 10.1007/BF00635615.View ArticlePubMedGoogle Scholar
- Searle C, Jeffrey J: Uncertainty and quality of life of adults hospitalized with life-threatening ventricular arrhythmias. Can J Cardiovasc Nurs. 1994, 5: 15-22.PubMedGoogle Scholar
- Arafa MA, Zaher SR, El Dowaty AA, Moneeb DE: Quality of life among parents of children with heart disease. Health Qual Life Outcomes. 2008, 6: 91-10.1186/1477-7525-6-91.View ArticlePubMedPubMed CentralGoogle Scholar
- Holm KE, Patterson Joan M, Rueter Martha A, Wamboldt F: Impact of uncertainty associated with a child's chronic health condition on parents' health. Families, Systems & Health. 2008, 26: 282-295.View ArticleGoogle Scholar
- Hendriks KS, Grosfeld FJ, Wilde AA, van den BJ, van Langen IM, van Tintelen JP, ten Kroode HF: High distress in parents whose children undergo predictive testing for long QT syndrome. Community Genet. 2005, 8: 103-113. 10.1159/000084778.View ArticlePubMedGoogle Scholar
- Smets EM, Stam MM, Meulenkamp TM, van Langen IM, Wilde AA, Wiegman A, de Wert GM, Tibben A: Health-related quality of life of children with a positive carrier status for inherited cardiovascular diseases. Am J Med Genet A. 2008, 146A: 700-707. 10.1002/ajmg.a.32218.View ArticlePubMedGoogle Scholar
- Hendriks KS, Grosfeld FJ, van Tintelen JP, van Langen IM, Wilde AA, Bout van den J, ten Kroode HF: Can parents adjust to the idea that their child is at risk for a sudden death?: Psychological impact of risk for long QT syndrome. Am J Med Genet A. 2005, 138A: 107-112. 10.1002/ajmg.a.30861.View ArticlePubMedGoogle Scholar
- Andersen J, Oyen N, Bjorvatn C, Gjengedal E: Living with long QT syndrome: a qualitative study of coping with increased risk of sudden cardiac death. J Genet Couns. 2008, 17: 489-498. 10.1007/s10897-008-9167-y.View ArticlePubMedGoogle Scholar
- Cox S, O'Donoghue AC, McKenna WJ, Steptoe A: Health related quality of life and psychological wellbeing in patients with hypertrophic cardiomyopathy. Heart. 1997, 78: 182-187.View ArticlePubMedPubMed CentralGoogle Scholar
- Ingles J, Lind JM, Phongsavan P, Semsarian C: Psychosocial impact of specialized cardiac genetic clinics for hypertrophic cardiomyopathy. Genet Med. 2008, 10: 117-120. 10.1097/GIM.0b013e3181612cc7.View ArticlePubMedGoogle Scholar
- Contopoulos-Ioannidis DG, Karvouni A, Kouri I, Ioannidis JP: Reporting and interpretation of SF-36 outcomes in randomised trials: systematic review. BMJ. 2009, 338: a3006-10.1136/bmj.a3006.View ArticlePubMedPubMed CentralGoogle Scholar
- Ware JE: SF-36 Health Survey Manual and Interpretation Guide. 1993, Boston: The Health Institute New England Medical CenterGoogle Scholar
- Loge JH, Kaasa S: Short form 36 (SF-36) health survey: normative data from the general Norwegian population. Scand J Soc Med. 1998, 26: 250-258.PubMedGoogle Scholar
- Loge JH, Kaasa S, Hjermstad MJ, Kvien TK: Translation and performance of the Norwegian SF-36 Health Survey in patients with rheumatoid arthritis. I. Data quality, scaling assumptions, reliability, and construct validity. J Clin Epidemiol. 1998, 51: 1069-1076. 10.1016/S0895-4356(98)00098-5.View ArticlePubMedGoogle Scholar
- Ware JE, Kosinski M, Gandek B, Aaronson NK, Apolone G, Bech P, Brazier J, Bullinger M, Kaasa S, Leplege A, Prieto L, Sullivan M: The factor structure of the SF-36 Health Survey in 10 countries: results from the IQOLA Project. International Quality of Life Assessment. J Clin Epidemiol. 1998, 51: 1159-1165. 10.1016/S0895-4356(98)00107-3.View ArticlePubMedGoogle Scholar
- Ware JE: SF-36 health survey update. Spine. 2000, 25: 3130-3139. 10.1097/00007632-200012150-00008.View ArticlePubMedGoogle Scholar
- Student: The Probable Error of the Mean. Biometrika. 1908, 1-25.Google Scholar
- Breakwell GM: A psychological framework for analysing risk. The Psychology of Risk. 2007, New York: Cambridge University Press, 1-11.View ArticleGoogle Scholar
- Loge JH, Abrahamsen AF, Ekeberg O, Kaasa S: Reduced health-related quality of life among Hodgkin's disease survivors: a comparative study with general population norms. Ann Oncol. 1999, 10: 71-77. 10.1023/A:1008315525997.View ArticlePubMedGoogle Scholar
- Von Wachenfeldt A, Brandberg Y, Johansson H, Fornander T: Socioeconomic status and quality of life of women with family history of breast cancer attending an oncogenetic counseling clinic - a comparison with general population. Acta Oncol. 2008, 1-7.Google Scholar
- Grosfeld FJ, Beemer FA, Lips CJ, Hendriks KS, ten Kroode HF: Parents' responses to disclosure of genetic test results of their children. Am J Med Genet. 2000, 94: 316-323. 10.1002/1096-8628(20001002)94:4<316::AID-AJMG10>3.0.CO;2-N.View ArticlePubMedGoogle Scholar
- Meulenkamp TM, Tibben A, Mollema ED, van Langen IM, Wiegman A, de Wert GM, de Beaufort ID, Wilde AA, Smets EM: Predictive genetic testing for cardiovascular diseases: impact on carrier children. Am J Med Genet A. 2008, 146A: 3136-3146. 10.1002/ajmg.a.32592.View ArticlePubMedGoogle Scholar
- Hendriks KS, Hendriks MM, Birnie E, Grosfeld FJ, Wilde AA, Bout van den J, Smets EM, van Tintelen JP, ten Kroode HF, van Langen IM: Familial disease with a risk of sudden death: a longitudinal study of the psychological consequences of predictive testing for long QT syndrome. Heart Rhythm. 2008, 5: 719-724. 10.1016/j.hrthm.2008.01.032.View ArticlePubMedGoogle Scholar
- Overland S, Glozier N, Maeland JG, Aaro LE, Mykletun A: Employment status and perceived health in the Hordaland Health Study (HUSK). BMC Public Health. 2006, 6: 219-10.1186/1471-2458-6-219.View ArticlePubMedPubMed CentralGoogle Scholar
- Resta R, Biesecker BB, Bennett RL, Blum S, Estabrooks HS, Strecker MN, Williams JL: A New Definition of Genetic Counseling: National Society of Genetic Counselors' Task Force Report. J Genet Couns. 2006, 15: 77-83. 10.1007/s10897-005-9014-3.View ArticlePubMedGoogle Scholar
- Farnsworth MM, Fosyth D, Haglund C, Ackerman MJ: When I go in to wake them ... I wonder: parental perceptions about congenital long QT syndrome. J Am Acad Nurse Pract. 2006, 18: 284-290. 10.1111/j.1745-7599.2006.00132.x.View ArticlePubMedGoogle Scholar
- Dysvik E, Vinsnes AG, Eikeland OJ: The effectiveness of a multidisciplinary pain management programme managing chronic pain. Int J Nurs Pract. 2004, 10: 224-234. 10.1111/j.1440-172X.2004.00485.x.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2350/11/27/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.