Table 5 Association analysis for the relationship between validated SNPs in the explored candidate genes and quantitative variables of hyperandrogenemia in PCOS with genetic effect sizes estimates derived for a log-additive genetic model (MC4R rs2229616 dominant genetic model) for the minor allele (see also Table 1).
| Â | testosterone [nmol/l] | FAI | bioavailable testosterone [ng/ml] | ||||||
|---|---|---|---|---|---|---|---|---|---|
gene (SNP) minor allele | β | 95% CI | p | β | 95% CI | p | β | 95% CI | p |
FTO (rs9939609) A | -0.01 | (-0.41;0.39) | 0.95 | 5.25 | (-7.11;17.60) | 0.41 | 0.03 | (-0.09;0.15) | 0.64 |
INSIG2 (rs7566605) C | -0.16 | (-0.58;0.26) | 0.46 | -6.33 | (-19.36;6.71) | 0.34 | -0.07 | (-0.20;0.05) | 0.25 |
TCF7L2 (rs7903146) T | 0.20 | (-0.25;0.64) | 0.38 | 7.93 | (-5.90;21.77) | 0.26 | 0.04 | (-0.09;0.18) | 0.50 |
MC4R (rs2229616) T | -0.28 | (-1.88;1.32) | 0.73 | -12.18 | (-60.54;36.17) | 0.62 | -0.08 | (-0.54;0.38) | 0.73 |
MC4R (rs17782313) C | -0.25 | (-0.70;0.19) | 0.27 | -3.47 | (-17.33;10.40) | 0.62 | -0.05 | (-0.18;0.08) | 0.46 |
MC4R (rs12970134) A | 0.15 | (-0.29;0.58) | 0.51 | 7.26 | (-5.97;20.49) | 0.28 | 0.07 | (-0.06;0.19) | 0.30 |