Table 2 rs7595412 SNP effects on osteoporosis traits in postmenopausal Danish women
A/A | A/G | G/G | Log-Additive (p value) | Recessive (p value) | Dominant (p value) | |
|---|---|---|---|---|---|---|
N | 943 | 229 | 19 | na | na | na |
Hip Bone Size (cm2) | 36.5 ± 3.6 | 36.4 ± 3.7 | 35.9 ± 4.0 | 0.26 | 0.47 | 0.30 |
Spine Bone Size (cm2) | 58.3 ± 5.3 | 58.1 ± 5.0 | 57.6 ± 6.2 | 0.49 | 0.57 | 0.55 |
Bone Mineral Density (g/cm2) | ||||||
Distal part of the arm | 0.358 ± 0.077 | 0.367 ± 0.072 | 0.335 ± 0.064 | 0.45 | 0.12 | 0.18 |
Femur Neck | 0.667 ± 0.105 | 0.666 ± 0.101 | 0.658 ± 0.075 | 0.44 | 0.62 | 0.47 |
Total Femur | 0.791 ± 0.122 | 0.784 ± 0.131 | 0.757 ± 0.083 | 0.16 | 0.19 | 0.24 |
Total Spine | 0.880 ± 0.149 | 0.890 ± 0.164 | 0.843 ± 0.122 | 0.94 | 0.24 | 0.66 |
Serum Crosslaps (ng/ml)# | 0.359 [0.189-0.684] | 0.351 [0.187-0.658] | 0.457 [0.230-0.905] | 0.68 | 0.10 | 0.97 |
Serum Osteocalcin (ng/ml)# | 29.19 [19.51-43.67] | 29.12 [19.46-43.59] | 35.57 [21.47-58.93] | 0.36 | 0.03 | 0.71 |
Vertebral fractures (Yes/No/na) | 177/729/37 | 34/192/3 | 3/16/0 | na | na | 0.04 |
Hip fractures (Yes/No/na) | 23/917/3 | 6/222/1 | 0/19/0 | na | na | 0.91 |