Table 2 Distribution of three SNPs in HUA cases and controls, stratified by gender
Gene/SNP | Male | Female | Total | |||
|---|---|---|---|---|---|---|
Case (%) (n = 78) | Control (%) (n = 621) | Case (%) (n = 73) | Control (%) (n = 434) | Case (%) (n = 151) | Control (%) (n = 1055) | |
SLC2A9 rs3733591 | ||||||
C/C | 10 (12.8) | 72 (11.6) | 13 (17.8) | 33 (7.6) | 23 (15.2) | 105 (10.0) |
C/T | 34 (43.6) | 284 (45.7) | 38 (52.1) | 198 (45.6) | 72 (47.4) | 482 (45.7) |
T/T | 34 (43.6) | 265 (42.7) | 22 (30.1) | 203 (46.8) | 56 (37.1) | 468 (44.4) |
pa | 0.91 | 0.003 | 0.075 | |||
Allele (%) | ||||||
C | 54 (34.6) | 428 (34.5) | 604 (69.6) | 264 (30.4) | 118 (39.1) | 692 (32.8) |
T | 102 (65.4) | 814 (65.5) | 82 (56.2) | 64 (43.8) | 184 (60.9) | 1418 (67.2) |
ABCG2 rs2231142 | ||||||
T/T | 8 (10.3) | 50 (8.1) | 10 (13.7) | 34 (7.8) | 18 (11.9) | 84 (8.0) |
T/G | 46 (59.0) | 253 (40.7) | 35 (47.9) | 173 (39.9) | 81 (53.6) | 426 (40.4) |
G/G | 24 (30.8) | 318 (51.2) | 28 (38.4) | 227 (52.3) | 52 (34.4) | 545 (51.7) |
pa | 0.003 | 0.053 | 6.37 × 10−5 | |||
Allele (%) | ||||||
T | 62 (39.7) | 353 (28.4) | 55 (37.7) | 241 (27.8) | 117 (38.7) | 594 (28.2) |
G | 94 (60.3) | 889 (71.6) | 91 (62.3) | 627 (72.2) | 185 (61.3) | 1516 (71.8) |
SLC22A12 rs893006 | ||||||
G/G | 51 (65.4) | 346 (55.7) | 39 (53.4) | 218 (50.2) | 90 (59.6) | 564 (53.5) |
G/T | 25 (32.1) | 234 (37.7) | 31 (42.5) | 187 (43.1) | 56 (37.1) | 421 (39.9) |
T/T | 2 (2.6) | 419 (6.6) | 3 (4.1) | 29 (6.7) | 5 (3.3) | 70 (6.6) |
pa | 0.16 | 0.67 | 0.17 | |||
Allele (%) | ||||||
G | 127 (81.4) | 926 (74.6) | 109 (74.7) | 623 (71.8) | 561 (26.6) | 1549 (73.4) |
T | 29 (18.6) | 316 (25.4) | 37 (25.3) | 245 (28.2) | 66 (21.9) | 236 (78.1) |