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Fig. 6 | BMC Medical Genetics

Fig. 6

From: A novel splice site indel alteration in the EIF2AK3 gene is responsible for the first cases of Wolcott-Rallison syndrome in Hungary

Fig. 6

Expression of CHOP and GRP78 proteins in liver of the Patient 2 with Wolcott-Rallison syndrome and a healthy control. 1st and 2nd row (a, b, c, d): H&E stain with different magnifications. 3rd row (e, f): CHOP immunohistological (IHC) staining (chromophore: VIP - purple). 4th row (g, h): GRP78 protein expression (IHC with VIP chromophore - purple). The tissue injury of the liver is severe, similarly to the pancreas in the WRS patient. The protective ER chaperon, GRP78 expressed tremendously accompanied with no CHOP expression in Patient 2. Control liver presents no tissue injury, extremely low GRP78 expression and a light immunostaining for CHOP

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BMC Medical Genetics

ISSN: 1471-2350

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