Skip to main content
Fig. 5 | BMC Medical Genetics

Fig. 5

From: A novel splice site indel alteration in the EIF2AK3 gene is responsible for the first cases of Wolcott-Rallison syndrome in Hungary

Fig. 5

Expression of insulin and EIF2AK3 proteins in pancreas of the Patient 2 with Wolcott-Rallison syndrome and a healthy control. 1st and 2nd row (a, b, c, d): H&E staining with different magnifications. 3rd row (e, f): Insulin immunohistological staining (chromophore: DAB - brown). 4th row (g, h): immunohistological staining by anti-EIF2AK3 antibody in Wolcott-Rallison syndrome and a control sample (chromophore: DAB - brown). The WRS samples present severe tissue injury with fibrotic remodeling with negative insulin staining in the Langerhans islands accompanied with negative EIF2AK3 protein expression. Control pancreas presents no tissue injury, and positive insulin-EIF2Ak3 immunoreactivity

Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us