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Table 3 Mediating effects of mQTL-associated CpG site(s) for association between each SNP and bladder cancer risk

From: Mediation by differential DNA methylation of known associations between single nucleotide polymorphisms and bladder cancer risk

SNP Region Gene RA Mediator(s) Effect of SNPa OR 95% CI
rs798766 4p16.3 TMEM129-TACC3-FGFR3 T cg00006948 NDE 1.16 (0.86, 1.50)
NIE 0.95 (0.81, 1.08)
TE 1.10 (0.85, 1.38)
rs401681 5p15.33 TERT-CLPTML C cg27028750 cg26209169 NDE 1.01 (0.76, 1.33)
NIE 1.05 (0.89, 1.25)
TE 1.05 (0.85, 1.30)
rs2294008 8q24.3 PSCA T cg06565975 cg03405983
cg24023258 cg17888033
cg17252645
NDE 1.04 (0.78, 1.35)
NIE 1.10 (0.90, 1.33)
TE 1.13 (0.91, 1.38)
rs8102137 19q12 CCNE1 C cg16836589 cg27475126 NDE 1.36 (1.05, 1.74)
NIE 1.02 (0.93, 1.11)
TE 1.38 (1.09, 1.74)
  1. aMediation models were adjusted for race/ethnicity, smoking status, pack-years of smoking, WHI arm, age at baseline, year of enrollment, follow-up time, and DNA extraction method
  2. Abbreviations: RA Risk allele; CI Confidence interval; NDE Natural direct effect; NIE Natural indirect effect; TE Total effect