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Table 1 Summary of pooled effect sizes of ABCG2 and SLC2A9 polymorphisms on gout and hyperuricemia

From: The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis

 

Asian

Caucasian

Na

I2

Pooled OR

95% CI

Lambdab

95% CI

Na

I2

Pooled OR

95% CI

Lambdab

95% CI

ABCG2

 Gout

  rs2231142

   OR1 (AA versus CC)

16

75.2

4.53

4.10, 5.00

0.463

0.332, 0.616

5

39.2

3.24

2.39, 4.41

0.461

0.253, 0.883

   OR2 (CA versus CC)

16

68.7

2.10

1.95, 2.26

  

5

62.9

1.64

1.47, 1.82

  

  rs72552713

   OR1 (TT versus CC)

8

0.0

3.86

2.30, 9.76

0.670

0.362, 0.978

      

   OR2 (CT versus CC)

8

0.0

2.46

1.93, 3.18

        

  rs2231137

   OR1 (AA versus GG)

6

54.6

0.43

0.34, 0.55

0.547

0.262, 0.925

      

   OR2 (GA versus GG)

6

54.9

0.64

0.56, 0.72

        

 Hyperuricemia

  rs2231142

   OR1 (AA versus CC)

3

67.2

2.25

1.80, 2.81

0.527

0.131, 0.940

      

   OR2 (CA versus CC)

3

44.6

1.56

1.35, 1.80

        

SLC2A9

 Gout

  rs1014290

   OR1 (CC versus TT)

6

55.0

0.42

0.36, 0.49

0.520

0.317, 0.847

3

0.0

0.57

0.37, 0.87

0.474

0.092, 0.954

   OR2 (TC versus TT)

6

0.0

0.65

0.58, 0.72

  

3

0.0

0.75

0.63, 0.89

  

  rs3733591

   OR1 (CC versus TT)

6

68.1

1.55

1.17, 2.06

0.512

0.087, 0.960

3

0.0

1.03

0.60, 1.79

0.463

0.021, 0.972

   OR2 (TC versus TT)

6

45.2

1.29

1.07, 1.55

  

3

28.8

0.85

0.48, 1.50

  

  rs6449213

   OR1 (CC versus TT)

      

5

29.0

0.38

0.29, 0.50

0.400

0.179, 0.829

   OR2 (TC versus TT)

      

5

0.0

0.69

0.62, 0.78

  

  rs6855911

   OR1 (GG versus AA)

3

0.0

0.61

0.20, 1.87

0.395

0.019, 0.963

2

40.0

0.36

0.28, 0.46

0.370

0.078, 0.872

   OR2 (AG versus AA)

3

0.0

0.82

0.53, 1.27

  

2

49.4

0.67

0.59, 0.77

  

  rs16890979

   OR1 (TT versus CC)

3

NAc

NAc

         

   OR2 (CT versus CC)

3

0.0

0.60

0.39, 0.94

        

  rs7442295

   OR1 (GG versus AA)

      

3

38.7

0.35

0.28, 0.46

0.401

0.163, 0.799

   OR2 (AG versus AA)

      

3

8.6

0.65

0.57, 0.74

  

  rs12510549

   OR1 (CC versus TT)

      

3

0.0

0.44

0.34, 0.58

0.528

0.216, 0.942

   OR2 (TC versus TT)

      

3

8.5

0.66

0.58, 0.76

  
  1. ABCG2 ATP-binding cassette sub-family G member 2, CI confidence interval, NA not applicable, OR odds ratio, SLC2A9 solute carrier family 2 member 9
  2. aNumber of sub-studies
  3. bMedian lambda
  4. cUnable to pool OR1 for rs16890979 due to no gout case with TT genotype found