From: Frequency of thrombophilia associated genes variants: population-based study
Main recommendation in patients: |
1. before the age of 50 with first unprovoked VTE or with recurrent VTE |
2. with VTE when the results of it may influence the treatment and clinical decisions |
3. with at least two VTE in the family or VTE cases which occurred in relatives of the first generation at an early age |
May be considered in several circumstances: |
4. like smoking females under the age of 50 with a history of acute myocardial infarction |
5. in siblings of individuals known to be homozygous for factor V Leiden or factor II c.*97G > A |
6. in an asymptomatic pregnant woman or a woman considering pregnancy, with first degree relatives with unprovoked VTE or VTE caused by pregnancy or by use of contraception can be considered to undergo this test |
7. in a pregnant woman’s family and a woman planning to conceive, the first degree relative who is the carrier of mutation Leiden and / or factor II c.* 97G > A and a history of VTE |
8. in women who plan to start taking contraceptives or have hormone replacement therapy |
The ACMG does not recommend routine testing for patients with a personal or family history of coronary artery disease or ischemic stroke |