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Table 3 The associations between SNPs and age of onset for heroin use

From: Association studies of dopamine synthesis and metabolism genes with multiple phenotypes of heroin dependence

Gene Variable/ID Age ≤ 28 (n = 440) Age > 28 (n = 361) Pa OR, 95% CI Pb Exp(B), 95% CI
   Number Percent Number Percent     
TH rs10770140      0.018n   0.092  
  TT 366 83.2 322 89.2 0.015n 0.599, 0.395–0.908 0.019n 0.568, 0.354–0.912
  TC 72 16.4 39 10.8 0.023 1.615, 1.064–2.452 0.032 1.681, 1.047–2.703
  CC 2 0.5 0 0.0 0.504 1.005, 0.998–1.011 0.999 0.000, 0.000-
  T 804 91.4 683 94.6 0.013n 0.604, 0.405–0.901   
  C 76 8.6 39 5.4     
  rs10770141      0.015n   0.071  
  GG 371 84.3 326 90.3 0.012n 0.577, 0.374–0.890 0.014n 0.538, 0.328–0.881
  GA 67 15.2 35 9.7 0.019 1.673, 1.083–2.585 0.024 1.77, 1.080–2.907
  AA 2 0.5 0 0.0 0.504 1.005, 0.998–1.001 0.999 0.000, 0.000-
  G 809 91.9 687 95.2 0.010n 0.580, 0.382–0.881   
  A 71 8.1 35 4.8     
  1. Pa: Genotypic and allele frequency difference assessment by chi-square test
  2. Pb: Genotypic and allele frequency difference assessment by binary logistic regression
  3. n: The result was not significant after Bonferroni’s correction