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Table 6 Regression analysis to determine the effect age, sex and polymorphisms on glaucoma risk

From: Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin

Group

Variables

B

SE

Wald

Odds ratio (95% confidence interval)

p

PACG

 Age

0.016

0.016

0.995

1.02 (0.98–1.04)

0.319

 Sex

−0. 467

0.255

3.371

0. 62 (0.38–1.03)

0. 066

 Rs12997

  

7.904

 

0.019

 A/G

−0. 262

0. 281

0. 870

0.77 (0.44–1.33)

0.351

 G/G

0.748

0.354

4.457

2.11 (1.05–4.23)

0.035

 Rs1043784

  

0.675

 

0.714

 T/C

0.185

0.297

0.389

1.20 (0.67–2.15)

0.533

 C/C

−0.329

0.709

0.216

0.72 (0.18–2.88)

0.642

 Constant

−1.498

0.961

2.43

0.223

0.119

PXG

 Age

0.075

0.017

20.488

1.08 (1.04–1.11)

0.000

 Sex

−0.299

0.278

1.159

1.34 (0.78–2.32)

0.282

 Rs12997

  

6.227

 

0.044

 A/G

0.188

0.295

0.404

1.20 (0.67–2.15)

0.525

 G/G

1.033

0.418

6.107

2.81 (1.23–6.37)

0.013

 Rs1043784

  

2.932

 

0.231

 T/C

0.455

0.303

2.26

1.57 (0.87–2.85)

0.133

 C/C

−0.559

0.854

0.427

0.57 (0.10–3.05)

0.513

 Constant

−6.028

1.095

30.318

0.002

0.000

  1. Abbreviations: PACG primary angle-closure glaucoma, PXG pseudoexfoliation glaucoma
  2. Significant p-value in bold