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Table 4 Association analysis of rs12997 variant in ACVR1 with primary pseudoexfoliation glaucoma

From: Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin

Group Genetic Model Genotype Control
n (%)
PXG
n (%)
OR (95% CI) p AIC BIC p§
Overall Co-dominant A/A 110 (44.4) 34 (35.8) 1.00 0.150 407.0 418.6 0.52
A/G 111 (44.8) 44 (46.3) 1.28 (0.76–2.16)
G/G 27 (10.9) 17 (17.9) 2.04 (0.99–4.18)
Dominant A/A 110 (44.4) 34 (35.8) 1.00 0.150 406.7 414.4 0.34
A/G-G/G 138 (55.6) 61 (64.2) 1.43 (0.88–2.33)
Recessive A/A-A/G 221 (89.1) 78 (82.1) 1.00 0.091 405.9 413.6 0.37
G/G 27 (10.9) 17 (17.9) 1.78 (0.92–3.45)
Over-dominant A/A-G/G 137 (55.2) 51 (53.7) 1.00 0.800 408.7 416.4 0.7
A/G 111 (44.8) 44 (46.3) 1.06 (0.66–1.71)
Log-additive 1.39 (0.99–1.97) 0.059* 405.2 412.9 0.25
Men Co-dominant A/A 55 (41.0) 23 (37.7) 1.00 0.460 246.8 256.6 0.82
A/G 62 (46.3) 26 (42.6) 1.00 (0.51–1.96)
G/G 17 (12.7) 12 (19.7) 1.69 (0.70–4.09)
Dominant A/A 55 (41.0) 23 (37.7) 1.00 0.660 246.1 252.7 0.83
A/G-G/G 79 (59.0) 38 (62.3) 1.15 (0.62–2.14)
Recessive A/A-A/G 117 (87.3) 49 (80.3) 1.00 0.210 244.8 251.3 0.53
G/G 17 (12.7) 12 (19.7) 1.69 (0.75–3.79)
Over-dominant A/A-G/G 72 (53.7) 35 (57.4) 1.00 0.630 246.1 252.6 0.85
A/G 62 (46.3) 26 (42.6) 0.86 (0.47–1.59)
Log-additive 1.24 (0.80–1.90) 0.340 245.4 252 0.64
Women Co-dominant A/A 55 (48.2) 11 (32.4) 1.00 0.230 162.5 171.5 0.45
A/G 49 (43.0) 18 (52.9) 1.84 (0.79–4.27)
G/G 10 (8.8) 5 (14.7) 2.50 (0.71–8.76)
Dominant A/A 55 (48.2) 11 (32.4) 1.00 0.098 160.8 166.8 0.22
A/G-G/G 59 (51.8) 23 (67.7) 1.95 (0.87–4.37)
Recessive A/A-A/G 104 (91.2) 29 (85.3) 1.00 0.330 162.6 168.6 0.54
G/G 10 (8.8) 5 (14.7) 1.79 (0.57–5.66)
Over-dominant A/A-G/G 65 (57.0) 16 (47.1) 1.00 0.310 162.5 168.5 0.38
A/G 49 (43.0) 18 (52.9) 1.49 (0.69–3.22)
Log-additive 1.64 (0.92–2.93) 0.091 160.7 166.7 0.22
  1. Abbreviations: AIC Akaike’s information criterion, BIC Bayesian information criterion, OR (95% CI) Odds ratio (95% confidence interval), PXG pseudoexfoliation glaucoma. Note: Significant odds ratio and p-value (trend) in bold. Bonferroni corrected p-value is 0.01
  2. §p-value adjusted for age and sex in overall group and by age in men and women groups; A/A vs G/G p-value = 0.049; *Best-fit model p-value