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Table 4 Association analysis of rs12997 variant in ACVR1 with primary pseudoexfoliation glaucoma

From: Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin

Group

Genetic Model

Genotype

Control

n (%)

PXG

n (%)

OR (95% CI)

p

AIC

BIC

p§

Overall

Co-dominant

A/A

110 (44.4)

34 (35.8)

1.00

0.150

407.0

418.6

0.52

A/G

111 (44.8)

44 (46.3)

1.28 (0.76–2.16)

G/G

27 (10.9)

17 (17.9)

2.04 (0.99–4.18)

Dominant

A/A

110 (44.4)

34 (35.8)

1.00

0.150

406.7

414.4

0.34

A/G-G/G

138 (55.6)

61 (64.2)

1.43 (0.88–2.33)

Recessive

A/A-A/G

221 (89.1)

78 (82.1)

1.00

0.091

405.9

413.6

0.37

G/G

27 (10.9)

17 (17.9)

1.78 (0.92–3.45)

Over-dominant

A/A-G/G

137 (55.2)

51 (53.7)

1.00

0.800

408.7

416.4

0.7

A/G

111 (44.8)

44 (46.3)

1.06 (0.66–1.71)

Log-additive

1.39 (0.99–1.97)

0.059*

405.2

412.9

0.25

Men

Co-dominant

A/A

55 (41.0)

23 (37.7)

1.00

0.460

246.8

256.6

0.82

A/G

62 (46.3)

26 (42.6)

1.00 (0.51–1.96)

G/G

17 (12.7)

12 (19.7)

1.69 (0.70–4.09)

Dominant

A/A

55 (41.0)

23 (37.7)

1.00

0.660

246.1

252.7

0.83

A/G-G/G

79 (59.0)

38 (62.3)

1.15 (0.62–2.14)

Recessive

A/A-A/G

117 (87.3)

49 (80.3)

1.00

0.210

244.8

251.3

0.53

G/G

17 (12.7)

12 (19.7)

1.69 (0.75–3.79)

Over-dominant

A/A-G/G

72 (53.7)

35 (57.4)

1.00

0.630

246.1

252.6

0.85

A/G

62 (46.3)

26 (42.6)

0.86 (0.47–1.59)

Log-additive

1.24 (0.80–1.90)

0.340

245.4

252

0.64

Women

Co-dominant

A/A

55 (48.2)

11 (32.4)

1.00

0.230

162.5

171.5

0.45

A/G

49 (43.0)

18 (52.9)

1.84 (0.79–4.27)

G/G

10 (8.8)

5 (14.7)

2.50 (0.71–8.76)

Dominant

A/A

55 (48.2)

11 (32.4)

1.00

0.098

160.8

166.8

0.22

A/G-G/G

59 (51.8)

23 (67.7)

1.95 (0.87–4.37)

Recessive

A/A-A/G

104 (91.2)

29 (85.3)

1.00

0.330

162.6

168.6

0.54

G/G

10 (8.8)

5 (14.7)

1.79 (0.57–5.66)

Over-dominant

A/A-G/G

65 (57.0)

16 (47.1)

1.00

0.310

162.5

168.5

0.38

A/G

49 (43.0)

18 (52.9)

1.49 (0.69–3.22)

Log-additive

1.64 (0.92–2.93)

0.091

160.7

166.7

0.22

  1. Abbreviations: AIC Akaike’s information criterion, BIC Bayesian information criterion, OR (95% CI) Odds ratio (95% confidence interval), PXG pseudoexfoliation glaucoma. Note: Significant odds ratio and p-value (trend) in bold. Bonferroni corrected p-value is 0.01
  2. §p-value adjusted for age and sex in overall group and by age in men and women groups; A/A vs G/G p-value = 0.049; *Best-fit model p-value