Clinical parameter | N (%) | PIN3 16-bp duplication | X2 | P value | ||
---|---|---|---|---|---|---|
A1A1% | A1A2% | A2A2% | ||||
Mean age at diagnosis | 43.72 ± 3.14 | 2.41* | 0.12 | |||
  ≤ 40 years of age | 29 (48.3) | 11 (37.9) | 12 (41.4) | 6 (20.7) |  |  |
  > 40 years of age | 31 (51.7) | 16 (51.6) | 13 (41.4) | 2 (6.5) |  |  |
Localization | Â | Â | Â | Â | 1.98 | 0.74 |
 Right breast | 19 (31.7) | 7 (36.8) | 9 (47.4) | 3 (15.8) |  |  |
 Left breast | 37 (61.7) | 19 (51.4) | 14 (37.8) | 4 (10.8) |  |  |
 Bilateral | 4 (6.6) | 1 (25.0) | 2 (50.0) | 1 (25.0) |  |  |
Use of contraceptives | Â | Â | Â | 0.56* | 0.45 | |
 No | 45 (75.0) | 18 (40.0) | 25 (55,6) | 2 (4.4) |  |  |
 Yes | 15 (25.0) | 9 (60.0) | – | 6 (40.0) |  |  |
Menopausal status | Â | Â | Â | Â | 3.15 | 0.53 |
 Pre-menopausal | 11 (18.3) | 6 (54.5) | 4 (36.4) | 1 (9.1) |  |  |
 Post-menopausal | 20 (33.3) | 10 (50.0) | 9 (45.0) | 1 (5.0) |  |  |
 Fertile women | 29 (48.3) | 11 (37.9) | 12 (41.4) | 6 (20.7) |  |  |
Parity | Â | Â | Â | Â | 7.33 | 0.12 |
 Nulliparity | 6 (10.0) | – | 5 (83.3) | 1 (16.7) |  |  |
 Primiparity | 9 (15.0) | 3 (33.3) | 4 (44.4) | 2 (22.2) |  |  |
 Multiparity | 45 (75.5) | 24 (53.3) | 16 (35.6) | 5 (11.1) |  |  |
Breastfeeding | Â | Â | Â | Â | 0.50* | 0.48 |
 Yes | 53 (88.3) | 26 (49.1) | 19 (35.8) | 8 (15.1) |  |  |
 No | 7 (11.7) | 1 (14.3) | 6 (85.7) | – |  |  |
Family history of BC | Â | Â | Â | Â | 0.64* | 0.42 |
 Yes | 8 (13.3) | 4 (50.0) | 4 (50.0) | – |  |  |
 No | 52 (86.7) | 23 (44.2) | 21 (40.4) | 8 (15.4) |  |  |
Personal history of benign breast disease | Â | Â | Â | Â | 1.69* | 0.19 |
 Yes | 6 (10.0) | 4 (66.7) | 2 (33.3) | – |  |  |
 No | 54 (90.0) | 23 (42.6) | 23 (42.6) | 8 (14.8) |  |  |
Obesity | Â | Â | Â | Â | 0.43 | 0.81 |
 Yes | 19 (31.7) | 8 (42.1) | 9 (47.4) | 2 (10.5) |  |  |
 No | 41 (68.3) | 19 (46.3) | 16 (39.0) | 6 (14.6) |  |  |
Smoking | Â | Â | Â | Â | 0.20* | 0.65 |
 Passive smoking | 7 (11.7) | 3 (42.9) | 4 (57.1) | – |  |  |
 No | 53 (88.3) | 24 (45.3) | 21 (39.6) | 8 (15.1) |  |  |
Histological type | Â | Â | Â | Â | 4.14* | 0.04 |
 Invasive ductal carcinoma | 56 (93.3) | 23 (41.1) | 25 (44.6) | 8 (14.3) |  |  |
 Others | 4 (6.7) | 4 (100.0) | – | – |  |  |
Tumor size | Â | Â | Â | Â | 5.63 | 0.46 |
 T1 | 1 (1.7) | – | 1 (100.0) | – |  |  |
 T2 | 10 (16.7) | 5 (50.0) | 5 (50.0) | – |  |  |
 T3 | 41 (68.3) | 18 (43.9) | 15 (36.6) | 8 (19.5) |  |  |
 T4 | 8 (13.3) | 4 (50.0) | 4 (50.0) | – |  |  |
Nodal involvement | Â | Â | Â | Â | Â | Â |
 N0 | 36 (60.0) | 16 (44.4) | 16 (44.4) | 4 (11.1) | 6.05 | 0.41 |
 N1 | 16 (26.7) | 5 (31.3) | 7 (43.8) | 4 (25.0) |  |  |
 N2 | 7 (11.7) | 5 (71.4) | 2 (28.6) | – |  |  |
 N3 | 1 (1.7) | 1 (100.0) | – | – |  |  |
Metastasis | Â | Â | Â | Â | 0.91* | 0.34 |
 M0 | 55 (91.7) | 24 (43.6) | 23 (41.8) | 8 (14.5) |  |  |
 M1 | 5 (8.3) | 3 (60.0) | 2 (40.0) | – |  |  |