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Table 1 Distribution of the PIN3 16-bp duplication polymorphism of TP53 according to the clinicopathological characteristics in Malian breast cancer

From: Association of PIN3 16-bp duplication polymorphism of TP53 with breast cancer risk in Mali and a meta-analysis

Clinical parameter N (%) PIN3 16-bp duplication X2 P value
A1A1% A1A2% A2A2%
Mean age at diagnosis 43.72 ± 3.14 2.41* 0.12
  ≤ 40 years of age 29 (48.3) 11 (37.9) 12 (41.4) 6 (20.7)   
  > 40 years of age 31 (51.7) 16 (51.6) 13 (41.4) 2 (6.5)   
Localization      1.98 0.74
 Right breast 19 (31.7) 7 (36.8) 9 (47.4) 3 (15.8)   
 Left breast 37 (61.7) 19 (51.4) 14 (37.8) 4 (10.8)   
 Bilateral 4 (6.6) 1 (25.0) 2 (50.0) 1 (25.0)   
Use of contraceptives     0.56* 0.45
 No 45 (75.0) 18 (40.0) 25 (55,6) 2 (4.4)   
 Yes 15 (25.0) 9 (60.0) 6 (40.0)   
Menopausal status      3.15 0.53
 Pre-menopausal 11 (18.3) 6 (54.5) 4 (36.4) 1 (9.1)   
 Post-menopausal 20 (33.3) 10 (50.0) 9 (45.0) 1 (5.0)   
 Fertile women 29 (48.3) 11 (37.9) 12 (41.4) 6 (20.7)   
Parity      7.33 0.12
 Nulliparity 6 (10.0) 5 (83.3) 1 (16.7)   
 Primiparity 9 (15.0) 3 (33.3) 4 (44.4) 2 (22.2)   
 Multiparity 45 (75.5) 24 (53.3) 16 (35.6) 5 (11.1)   
Breastfeeding      0.50* 0.48
 Yes 53 (88.3) 26 (49.1) 19 (35.8) 8 (15.1)   
 No 7 (11.7) 1 (14.3) 6 (85.7)   
Family history of BC      0.64* 0.42
 Yes 8 (13.3) 4 (50.0) 4 (50.0)   
 No 52 (86.7) 23 (44.2) 21 (40.4) 8 (15.4)   
Personal history of benign breast disease      1.69* 0.19
 Yes 6 (10.0) 4 (66.7) 2 (33.3)   
 No 54 (90.0) 23 (42.6) 23 (42.6) 8 (14.8)   
Obesity      0.43 0.81
 Yes 19 (31.7) 8 (42.1) 9 (47.4) 2 (10.5)   
 No 41 (68.3) 19 (46.3) 16 (39.0) 6 (14.6)   
Smoking      0.20* 0.65
 Passive smoking 7 (11.7) 3 (42.9) 4 (57.1)   
 No 53 (88.3) 24 (45.3) 21 (39.6) 8 (15.1)   
Histological type      4.14* 0.04
 Invasive ductal carcinoma 56 (93.3) 23 (41.1) 25 (44.6) 8 (14.3)   
 Others 4 (6.7) 4 (100.0)   
Tumor size      5.63 0.46
 T1 1 (1.7) 1 (100.0)   
 T2 10 (16.7) 5 (50.0) 5 (50.0)   
 T3 41 (68.3) 18 (43.9) 15 (36.6) 8 (19.5)   
 T4 8 (13.3) 4 (50.0) 4 (50.0)   
Nodal involvement       
 N0 36 (60.0) 16 (44.4) 16 (44.4) 4 (11.1) 6.05 0.41
 N1 16 (26.7) 5 (31.3) 7 (43.8) 4 (25.0)   
 N2 7 (11.7) 5 (71.4) 2 (28.6)   
 N3 1 (1.7) 1 (100.0)   
Metastasis      0.91* 0.34
 M0 55 (91.7) 24 (43.6) 23 (41.8) 8 (14.5)   
 M1 5 (8.3) 3 (60.0) 2 (40.0)   
  1. X2 Chi-squared test, P p-value, * Chi-squared test two-sided, N Number, BC Breast cancer, A1A1 Wild-type, A1A2 heterozygous, A2A2 homozygous mutant, % Percentagwe, Other histological type: Glycogen-rich clear cell carcinoma, lobular carcinoma in situ, Moderately differentiated adenocarcinoma and infiltrating adenocarcinoma.