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Table 1 Characteristics of 22 XLA male patients

From: Clinical characteristics and prenatal diagnosis for 22 families in Henan Province of China with X-linked agammaglobulinemia (XLA) related to Bruton’s tyrosine kinase (BTK) gene mutations

PatientsAge at onset, yAge at diagnosis, yCD19+ B cells, %IgG,g/l (5.66–14.25)IgA,g/l(0.8–5)IgM,g/l (0.3–2.09)Clinical presentation
P1121(6–25)0.5100.0600.060Pneumonia, herpetic stomatitis
P2350(6–25)< 0.810< 0.3300.300Mycoplasmal pneumoniae
P36 months40.00(5.0–18.0)0.1700.0300.220Sepsis, bilateral otitis media, sepsis
P414151(6–25)< 1.770< 0.060< 0.080Infectious diarrhea, dystrophic anemia
P57 months10 months0.2400.0300.200Bronchopneumonia, gastrointestinal dysfunction
P69260.260
P7270.23(6–25)< 0.020< 0.070< 0.150Central nervous system infection, epilepsy, upper respiratory infection, hydronephrosis
P8390.0(5.0–18.0)0.7100.0100.130Bronchopneumonia, bronchiectasis, airway hyperresponsiveness, sinusitis
P93130.00(5.0–18.0)4.4000.4600.570Bronchopneumonia, pleural effusion
P1020 days40.00(5.0–18.0)5.6400.1100.050Pneumonia, bronchiectasis
P11550(6–25)< 0.550< 0.050< 0.200Acute upper respiratory tract infection, viral encephalitis, pneumonia
P12781(6–25)< 0.800< 0.090< 0.220Bronchopneumonia
P13330.00(5.0–18.0)1.5000.7900.760Bronchopneumonia, dilated cardiomyopathy, Vitamin k deficiency, Upper respiratory tract infection, sepsis
P14270.04(5.0–18.0)
P1523.50.1000.0000.040Pneumonia
P161100.00(5.0–18.0)0.4100.0200.040Recurrent cough, bronchiectasis, pulmonary infection, hepatitis B virus carrier
P179 months20(6–25)< 0.100< 0.090< 0.18Pneumonia
P18150.00(5.0–18.0)0.1000.0200.040Bronchopneumonia
P1928< 2.090< 0.000< 0.000Pulmonary infection, bronchiectasis, sinusitis
P2033< 0.030< 0.000< 0.060Pneumonia, iron-deficiency anemia, hypoalbuminemia
P216 months80.300
P226 months50.03(5.0–18.0)< 0.740< 0.000< 0.130Perianal abscess, anal fistula, chronic nasosinusitis, otitis media, sepsis