A novel pathogenic variant in the LRTOMT gene causes autosomal recessive non-syndromic hearing loss in an Iranian family

Table 1 In silico analysis of identified variants in the LRTOMT gene

Variant/genomic Location	Exon	Amio- acid alteration	Database	Software	SIFT	Mutation Taster2.0	PROVEAN	PANTHER
c.509_524del (CAGTGGCTGAAAAACT) Frameshift mutation (Long InDel)	6	A170Afs*20	1000 G	state	Deleterious	Disease-Causing	Deleterious	Deleterious
			Not found	state	Deleterious	Disease-Causing	Deleterious	Deleterious
			ExAC	Score	0.894	NA	−4.709	–
			Not found	Score	0.894	NA	−4.709	–

ISSN: 1471-2350