Quantitative phenotype scan statistic (QPSS) reveals rare variant associations with Alzheimer’s disease endophenotypes

Table 1 Type I error estimates with Bonferroni correction

	Window size/sliding window size (m = the number of sliding windows in the region G)
	5 k/2.5 k (m = 400)	2 k/1 k (m = 1000)	1 k/500 (m = 2000)	500/250 (m = 4000)
n = 500
α = 0.05	0.047	0.054	0.053	0.051
α = 0.01	0.008	0.016	0.007	0.011
n = 1000
α = 0.05	0.051	0.052	0.051	0.033
α = 0.01	0.013	0.009	0.012	0.008

Empirical type I error rates were estimated as proportion of p-values less than or equal to the corresponding Bonferroni-corrected significance level (α* = α /m) for the window where \( \ln {\hat{LR}}_W \) is maximized

ISSN: 1471-2350