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Table 1 Type I error estimates with Bonferroni correction

From: Quantitative phenotype scan statistic (QPSS) reveals rare variant associations with Alzheimer’s disease endophenotypes

  Window size/sliding window size (m = the number of sliding windows in the region G)
5 k/2.5 k (m = 400) 2 k/1 k (m = 1000) 1 k/500 (m = 2000) 500/250 (m = 4000)
n = 500
 α = 0.05 0.047 0.054 0.053 0.051
 α = 0.01 0.008 0.016 0.007 0.011
n = 1000
 α = 0.05 0.051 0.052 0.051 0.033
 α = 0.01 0.013 0.009 0.012 0.008
  1. Empirical type I error rates were estimated as proportion of p-values less than or equal to the corresponding Bonferroni-corrected significance level (α* = α /m) for the window where \( \ln {\hat{LR}}_W \) is maximized