Association between the IL-10 and IL-6 polymorphisms and brucellosis susceptibility: a meta-analysis

Jin, Xiaochun; Wu, Yueyuan; Yin, Shuzhou; Chen, Xu; Zhang, Youtao

doi:10.1186/s12881-020-01006-0

BMC Medical Genetics

Table 3 The general results for the association between IL-10, IL-6 polymorphisms with Brucellosis risk

From: Association between the IL-10 and IL-6 polymorphisms and brucellosis susceptibility: a meta-analysis

Comparison	Group (sample size)	Test of association			Mode	Test of Heterogeneity
Comparison	Group (sample size)	OR	95%CI	P	Mode	x²	P	I²
IL-6-174 (G → C)
G versus. C	Overall(452/377)	1.09	0.87–1.36	0.468	Fixed	1.27	0.867	0
	Caucasian(202/235)	1.09	0.82–1.46	0.544	Fixed	1.14	0.567	0
	Asian(250/142)	1.07	0.76–1.52	0.685	Fixed	0.13	0.724	0
GG versus. CC	Overall(452/377)	1.28	0.71–2.28	0.410	Fixed	4.33	0.363	7.7
	Caucasian(202/235)	1.15	0.43–3.12	0.780	Fixed	3.61	0.164	44.6
	Asian(250/142)	1.78	0.69–4.55	0.232	Fixed	0	0.976	0
GG versus. CC/GC	Overall(452/377)	1.03	0.77–1.38	0.852	Fixed	3.64	0.457	0
	Caucasian(202/235)	1.04	0.63–1.73	0.869	Fixed	3.37	0.185	40.7
	Asian(250/142)	0.97	0.62–1.52	0.905	Fixed	0.15	0.699	0
GG/GC versus. CC	Overall(452/377)	1.30	0.62–2.73	0.487	Fixed	6.95	0.138	42.5
	Caucasian(202/235)	1.16	0.35–3.87	0.809	Random	5.53	0.063	63.8
	Asian(250/142)	1.87	0.74–4.71	0.184	Fixed	0.02	0.891	0
IL-10-1082 (G → A)
A versus. G	Overall(458/377)	0.82	0.62–1.08	0.152	Fixed	6.94	0.139	42.4
	Caucasian(208/236)	0.76	0.49–1.18	0.217	Random	4.90	0.086	59.1
	Asian(250/141)	0.89	0.58–1.37	0.602	Fixed	1.78	0.182	44.0
AA versus. GG	Overall(458/377)	1.51	0.87–2.60	0.142	Fixed	5.07	0.281	21.1
	Caucasian(208/236)	1.36	0.58–3.18	0.484	Random	4.20	0.123	52.4
	Asian(250/141)	1.95	0.83–4.58	0.124	Fixed	0.37	0.544	0
AA versus. GG/GA	Overall(458/377)	0.80	0.49–1.30	0.360	Random	9.76	0.045	59
	Caucasian(208/236)	0.62	0.39–0.98	0.043	Fixed	2.75	0.252	27.4
	Asian(250/141)	1.42	0.39–5.23	0.598	Random	4.66	0.031	78.5
AA/GA versus. GG	Overall(458/377)	0.72	0.39–1.32	0.291	Fixed	7.06	0.133	43.4
	Caucasian(208/236)	0.96	0.44–2.09	0.916	Random	2.75	0.126	51.7
	Asian(250/141)	0.42	0.19–0.94	0.035	Fixed	4.66	0.678	0
-819 (C → T)
T versus. C	Overall(458/377)	0.90	0.62–1.31	0.587	Random	11.71	0.02	65.8
	Caucasian(208/236)	1.22	0.91–1.63	0.190	Fixed	1.28	0.528	0
	Asian(250/141)	0.60	0.44–0.82	0.001	Fixed	0.02	0.889	0
TT versus. CC	Overall(458/377)	0.71	0.28–1.81	0.471	Random	9.96	0.041	59.8
	Caucasian(208/236)	1.22	0.56–2.65	0.615	Fixed	2.54	0.280	21.4
	Asian(250/141)	0.24	0.09–0.62	0.003	Fixed	0.15	0.694	0
TT versus. CC/TC	Overall(458/377)	0.68	0.28–1.65	0.393	Random	9.77	0.044	59.1
	Caucasian(208/236)	1.15	0.60–2.23	0.670	Fixed	1.96	0.375	0
	Asian(250/141)	0.22	0.05–0.91	0.036	Fixed	1.30	0.254	23.2
TT/TC versus. CC	Overall(458/377)	1.33	0.73–2.44	0.353	Random	15.88	0.003	74.8
	Caucasian(208/236)	1.31	0.90–1.90	0.160	Fixed	0.44	0.802	0
	Asian(250/141)	1.62	0.19–13.80	0.658	Random	13.99	0	92.9
-592 (C → A)
A versus. C	Overall(373/292)	0.90	0.64–1.26	1.524	Fixed	7.56	0.109	47.1
	Caucasian(123/151)	1.05	0.70–1.56	0.813	Fixed	2.21	0.331	9.6
	Asian(250/141)	0.78	0.44–1.38	0.393	Random	3.55	0.059	71.9
AA versus. CC	Overall(373/292)	0.58	0.32–1.06	0.076	Fixed	4.49	0.344	10.9
	Caucasian(123/151)	0.77	0.32–1.85	0.564	Fixed	0.76	0.683	0
	Asian(250/141)	0.48	0.14–1.67	0.248	Random	2.99	0.084	66.5
AA versus. CC/CA	Overall(373/292)	0.63	0.37–1.07	0.086	Fixed	2.91	0.573	0
	Caucasian(123/151)	0.86	0.38–1.94	0.710	Fixed	0.05	0.167	0
	Asian(250/141)	0.51	0.19–1.33	0.168	Random	1.91	0.078	47.7
AA/CA versus. CC	Overall(373/292)	0.80	0.51–1.26	0.345	Fixed	6.10	0.192	34.4
	Caucasian(123/151)	0.78	0.34–1.80	0.567	Fixed	3.89	0.235	30.9
	Asian(250/141)	0.80	0.40–1.67	0.535	Random	3.15	0.076	68.2

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