Gene | SNP ID | Allelic and Genotypic Frequencies in Cases and Controls | Â | Â | ||||
---|---|---|---|---|---|---|---|---|
Allele/Genotype | Cases: total number = 222 n(%) | Controls: total number = 218 n(%) | P-value* | Pearson Chi-square | Odd Ratio | CI (95%) | ||
CYP19A1 | rs7176005 | C | 341(0.77) | 370(0.85) | 0.002 | 9.408 | 0.584 | 0.4132–0.8254 |
T | 101(0.23) | 64(0.15) | ||||||
CC | 132(0.6) | 155(0.71) | 0.003 | 11.06 | 5.3538 | 1.1497–24.9301 | ||
CT | 77(0.35) | 60(0.28) | ||||||
TT | 12(0.05) | 2(0.01) | ||||||
rs6493497 | G | 343(0.78) | 368(0.85) | 0.005 | 7.57 | 0.615 | 0.4341–0.8711 | |
A | 97(0.22) | 64(0.15) | ||||||
GG | 12(0.05) | 2(0.01) | 0.008 | 9.627 | 5.7049 | 1.2236–26.5984 | ||
GA | 73(0.33) | 60(0.28) | ||||||
AA | 135(0.61) | 154(0.71) | ||||||
rs700519 | G | 430 (0.97) | 425(0.98) | 0.534 | 0.385 | 0.7588 | 0.3164–1.8196 | |
A | 12 (0.03) | 9(0.02) | ||||||
AG | 12(0.05) | 9(0.04) | 0.530 | 0.394 | 0.7536 | 0.3109–1.8266 | ||
GG | 209(0.95) | 208(0.96) | ||||||
rs10046 | G | 252(0.58) | 243(0.56) | 0.537 | 0.381 | 1.0883 | 0.8318–1.424 | |
A | 182(0.42) | 191(0.44) | ||||||
AA | 34(0.16) | 42(0.19) | 0.585 | 1.071 | 0.6577 | 0.3764–1.1493 | ||
GA | 114(0.53) | 107(0.49) | ||||||
GG | 69(0.32) | 68(0.31) | ||||||
rs4646 | C | 313(0.71) | 309(0.71) | N/A | N/A | 0.9972 | 0.7454–1.3342 | |
A | 129(0.29) | 127(0.29) | ||||||
AA | 22(0.1) | 22(0.1) | 0.996 | 0.008 | 0.9683 | 0.4867–1.9264 | ||
CA | 85(0.38) | 83(0.38) | ||||||
CC | 114(0.52) | 113(0.52) | ||||||
CYP2C9 | rs1799853 | C | 377(0.86) | 367(0.85) | 0.424 | 0.638 | 1.1665 | 0.7991–1.7029 |
T | 59(0.14) | 67(0.15) | ||||||
CC | 166(0.76) | 159(0.73) | 0.752 | 0.569 | 0.8187 | 0.2772–2.4179 | ||
CT | 45(0.21) | 49(0.23) | ||||||
TT | 7(0.03) | 9(0.04) | ||||||
CYP2C19 | rs4244285 | G | 383(0.89) | 390(0.92) | 0.060 | 3.515 | 0.6413 | 0.4019–1.0233 |
A | 49(0.11) | 32(0.08) | ||||||
AA | 3(0.01) | 1(0.0) | 0.170 | 3.543 | 2.175 | 0.2152–21.9809 | ||
AG | 43(0.2) | 30(0.14) | ||||||
GG | 170(0.79) | 180(0.85) | ||||||
CYP1B1 | rs10175368 | C | 310(0.71) | 318(0.74) | 0.350 | 0.87 | 0.8682 | 0.6452–1.1684 |
T | 128(0.29) | 114(0.26) | ||||||
CC | 109(0.5) | 121(0.56) | 0.340 | 2.156 | 0.7297 | 0.3512–1.5163 | ||
CT | 92(0.42) | 76(0.35) | ||||||
TT | 18(0.08) | 19(0.09) | ||||||
CYP3A4 | rs35599367 | G | 431(0.98) | 425(0.97) | 0.974 | 0.001 | 1.0141 | 0.435–2.3642 |
A | 11(0.02) | 11(0.03) | ||||||
GA | 11(0.05) | 11(0.05) | 0.974 | 0.001 | 1.0145 | 0.4304–2.3914 | ||
GG | 210(0.95) | 207(0.95) | ||||||
CYP1A2 | rs762551 | A | 295(0.67) | 274(0.63) | 0.225 | 1.472 | 1.188 | 0.8993–1.5695 |
C | 145(0.33) | 160(0.37) | ||||||
AA | 98(0.45) | 95(0.44) | 0.004 | 10.916 | 0.3712 | 0.1968–0.7003 | ||
AC | 99(0.45) | 84(0.39) | ||||||
CC | 23(0.1) | 38(0.18) |