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Table 3 Association of the investigated CYP450 candidate gene polymorphisms and breast cancer (BC)

From: Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population

Gene

SNP ID

Allelic and Genotypic Frequencies in Cases and Controls

  

Allele/Genotype

Cases: total number = 222

n(%)

Controls: total number = 218

n(%)

P-value*

Pearson Chi-square

Odd Ratio

CI (95%)

CYP19A1

rs7176005

C

341(0.77)

370(0.85)

0.002

9.408

0.584

0.4132–0.8254

T

101(0.23)

64(0.15)

CC

132(0.6)

155(0.71)

0.003

11.06

5.3538

1.1497–24.9301

CT

77(0.35)

60(0.28)

TT

12(0.05)

2(0.01)

rs6493497

G

343(0.78)

368(0.85)

0.005

7.57

0.615

0.4341–0.8711

A

97(0.22)

64(0.15)

GG

12(0.05)

2(0.01)

0.008

9.627

5.7049

1.2236–26.5984

GA

73(0.33)

60(0.28)

AA

135(0.61)

154(0.71)

rs700519

G

430 (0.97)

425(0.98)

0.534

0.385

0.7588

0.3164–1.8196

A

12 (0.03)

9(0.02)

AG

12(0.05)

9(0.04)

0.530

0.394

0.7536

0.3109–1.8266

GG

209(0.95)

208(0.96)

rs10046

G

252(0.58)

243(0.56)

0.537

0.381

1.0883

0.8318–1.424

A

182(0.42)

191(0.44)

AA

34(0.16)

42(0.19)

0.585

1.071

0.6577

0.3764–1.1493

GA

114(0.53)

107(0.49)

GG

69(0.32)

68(0.31)

rs4646

C

313(0.71)

309(0.71)

N/A

N/A

0.9972

0.7454–1.3342

A

129(0.29)

127(0.29)

AA

22(0.1)

22(0.1)

0.996

0.008

0.9683

0.4867–1.9264

CA

85(0.38)

83(0.38)

CC

114(0.52)

113(0.52)

CYP2C9

rs1799853

C

377(0.86)

367(0.85)

0.424

0.638

1.1665

0.7991–1.7029

T

59(0.14)

67(0.15)

CC

166(0.76)

159(0.73)

0.752

0.569

0.8187

0.2772–2.4179

CT

45(0.21)

49(0.23)

TT

7(0.03)

9(0.04)

CYP2C19

rs4244285

G

383(0.89)

390(0.92)

0.060

3.515

0.6413

0.4019–1.0233

A

49(0.11)

32(0.08)

AA

3(0.01)

1(0.0)

0.170

3.543

2.175

0.2152–21.9809

AG

43(0.2)

30(0.14)

GG

170(0.79)

180(0.85)

CYP1B1

rs10175368

C

310(0.71)

318(0.74)

0.350

0.87

0.8682

0.6452–1.1684

T

128(0.29)

114(0.26)

CC

109(0.5)

121(0.56)

0.340

2.156

0.7297

0.3512–1.5163

CT

92(0.42)

76(0.35)

TT

18(0.08)

19(0.09)

CYP3A4

rs35599367

G

431(0.98)

425(0.97)

0.974

0.001

1.0141

0.435–2.3642

A

11(0.02)

11(0.03)

GA

11(0.05)

11(0.05)

0.974

0.001

1.0145

0.4304–2.3914

GG

210(0.95)

207(0.95)

CYP1A2

rs762551

A

295(0.67)

274(0.63)

0.225

1.472

1.188

0.8993–1.5695

C

145(0.33)

160(0.37)

AA

98(0.45)

95(0.44)

0.004

10.916

0.3712

0.1968–0.7003

AC

99(0.45)

84(0.39)

CC

23(0.1)

38(0.18)

  1. CI confidence interval
  2. *P-Value < 0.0045 considered as significant