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Table 3 Association of the investigated CYP450 candidate gene polymorphisms and breast cancer (BC)

From: Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population

Gene SNP ID Allelic and Genotypic Frequencies in Cases and Controls   
Allele/Genotype Cases: total number = 222
n(%)
Controls: total number = 218
n(%)
P-value* Pearson Chi-square Odd Ratio CI (95%)
CYP19A1 rs7176005 C 341(0.77) 370(0.85) 0.002 9.408 0.584 0.4132–0.8254
T 101(0.23) 64(0.15)
CC 132(0.6) 155(0.71) 0.003 11.06 5.3538 1.1497–24.9301
CT 77(0.35) 60(0.28)
TT 12(0.05) 2(0.01)
rs6493497 G 343(0.78) 368(0.85) 0.005 7.57 0.615 0.4341–0.8711
A 97(0.22) 64(0.15)
GG 12(0.05) 2(0.01) 0.008 9.627 5.7049 1.2236–26.5984
GA 73(0.33) 60(0.28)
AA 135(0.61) 154(0.71)
rs700519 G 430 (0.97) 425(0.98) 0.534 0.385 0.7588 0.3164–1.8196
A 12 (0.03) 9(0.02)
AG 12(0.05) 9(0.04) 0.530 0.394 0.7536 0.3109–1.8266
GG 209(0.95) 208(0.96)
rs10046 G 252(0.58) 243(0.56) 0.537 0.381 1.0883 0.8318–1.424
A 182(0.42) 191(0.44)
AA 34(0.16) 42(0.19) 0.585 1.071 0.6577 0.3764–1.1493
GA 114(0.53) 107(0.49)
GG 69(0.32) 68(0.31)
rs4646 C 313(0.71) 309(0.71) N/A N/A 0.9972 0.7454–1.3342
A 129(0.29) 127(0.29)
AA 22(0.1) 22(0.1) 0.996 0.008 0.9683 0.4867–1.9264
CA 85(0.38) 83(0.38)
CC 114(0.52) 113(0.52)
CYP2C9 rs1799853 C 377(0.86) 367(0.85) 0.424 0.638 1.1665 0.7991–1.7029
T 59(0.14) 67(0.15)
CC 166(0.76) 159(0.73) 0.752 0.569 0.8187 0.2772–2.4179
CT 45(0.21) 49(0.23)
TT 7(0.03) 9(0.04)
CYP2C19 rs4244285 G 383(0.89) 390(0.92) 0.060 3.515 0.6413 0.4019–1.0233
A 49(0.11) 32(0.08)
AA 3(0.01) 1(0.0) 0.170 3.543 2.175 0.2152–21.9809
AG 43(0.2) 30(0.14)
GG 170(0.79) 180(0.85)
CYP1B1 rs10175368 C 310(0.71) 318(0.74) 0.350 0.87 0.8682 0.6452–1.1684
T 128(0.29) 114(0.26)
CC 109(0.5) 121(0.56) 0.340 2.156 0.7297 0.3512–1.5163
CT 92(0.42) 76(0.35)
TT 18(0.08) 19(0.09)
CYP3A4 rs35599367 G 431(0.98) 425(0.97) 0.974 0.001 1.0141 0.435–2.3642
A 11(0.02) 11(0.03)
GA 11(0.05) 11(0.05) 0.974 0.001 1.0145 0.4304–2.3914
GG 210(0.95) 207(0.95)
CYP1A2 rs762551 A 295(0.67) 274(0.63) 0.225 1.472 1.188 0.8993–1.5695
C 145(0.33) 160(0.37)
AA 98(0.45) 95(0.44) 0.004 10.916 0.3712 0.1968–0.7003
AC 99(0.45) 84(0.39)
CC 23(0.1) 38(0.18)
  1. CI confidence interval
  2. *P-Value < 0.0045 considered as significant