Fig. 2
![Fig. 2](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12881-019-0878-8/MediaObjects/12881_2019_878_Fig2_HTML.png)
Locations of the mutations in the human GAA structure (PDB: 5NN8, [21]). a The positions of the novel mutations are indicated by residue sticks with blue color and the previously reported mutations are indicated by residue sticks with green color, respectively. b, c and d Close-up view of the position p.Ala261Thr, p.Asp513Gly and p.Leu632Arg, respectively