Table 2 Distribution of IL7 genotypes and haplotypes in the clinical groups
Genetic Variants | Total (n = 883) | UM ( n = 718) | SMA (n = 165) | P-value |
|---|---|---|---|---|
Genotypes | ||||
IL7 (72194 T/C) | ||||
TT, n (%) | 391 (44.30) | 318 (44.30) | 73 (44.20) | 0.98 |
TC, n (%) | 399 (45.20) | 325 (45.30) | 74 (44.80) | |
CC, n (%) | 93 (10.50) | 75 (10.40) | 18 (10.90) | |
IL7 (−2440 A/G) | ||||
AA, n (%) | 733 (83.00) | 601 (83.70) | 132 (80.00) | 0.51 |
AG, n (%) | 142 (16.10) | 111 (15.50) | 31 (18.80) | |
GG, n (%) | 8 (0.90) | 6 (0.80) | 2 (1.20) | |
Haplotypes | ||||
TA | ||||
0 | 99 (11.20) | 79 (11.00) | 20 (12.10) | 0.68 |
1 | 784 (88.70) | 639 (89.00) | 145 (87.90) | |
TG | ||||
0 | 821 (93.00) | 674 (93.90) | 147 (89.10) | 0.03 |
1 | 62 (7.00) | 44 (6.10) | 18 (10.90) | |
THAT | ||||
0 | 468 (53.10) | 382 (53.20) | 86 (52.10) | 0.80 |
1 | 415 (46.90) | 336 (46.80) | 79 (47.90) | |
CG | ||||
0 | 792 (89.70) | 642 (89.40) | 150 (90.90) | 0.57 |
1 | 91 (10.30) | 76 (10.60) | 15 (9.10) | |