Genetic impact of methylenetetrahydrofolate reductase (MTHFR) polymorphism on the susceptibility to colorectal polyps: a meta-analysis

Sun, Manyi; Zhong, Jin; Zhang, Li; Shi, Songli

doi:10.1186/s12881-019-0822-y

Table 1 Main features of eligible studies for pooled analysis

From: Genetic impact of methylenetetrahydrofolate reductase (MTHFR) polymorphism on the susceptibility to colorectal polyps: a meta-analysis

First author	Year	NOS	Polymorphism	Case			Disease type	Control			Country	Ethnicity	Genotyping assay	P _HWE
First author	Year	NOS	Polymorphism	A/A	A/B	B/B	Disease type	A/A	A/B	B/B	Country	Ethnicity	Genotyping assay	P _HWE
Al-Ghnaniem [14]	2007	7	rs1801133	22	12	1	adenomatous polyps	41	29	6	UK	Caucasian	PCR-RFLP	0.784
			rs1801133	11	3	3	hyperplastic polyps	41	29	6	UK	Caucasian	PCR-RFLP	0.784
			rs1801131	18	12	5	adenomatous polyps	47	26	3	UK	Caucasian	PCR-RFLP	0.799
			rs1801131	8	7	2	hyperplastic polyps	47	26	3	UK	Caucasian	PCR-RFLP	0.799
Ashktorab [15]	2007	6	rs1801133	18	4	0	colorectal polyps	30	5	0	USA	Caucasian	PCR-RFLP	0.649
Beckett [16]	2015	5	rs1801133	29	20	7	adenomatous polyps	88	91	18	Australia	Caucasian	PCR-RFLP	0.421
Beckett [16]			rs1801131	28	22	6	adenomatous polyps	101	83	13	Australia	Caucasian	PCR-RFLP	0.460
Chen [17]	1998	8	rs1801133	102	126	30	adenomatous polyps	323	324	66	USA	Caucasian	PCR-RFLP	0.234
Chiang [18]	2015	7	rs1801133	44	26	0	adenomatous polyps	91	73	18	China	Asian	PCR-RFLP	0.553
de Vogel [19]	2011	6	rs1801133	947	714	135	adenomatous polyps	4463	3563	708	Norway	Caucasian	Real-time PCR	0.933
Delgado [20]	2001	8	rs1801133	6	19	7	adenomatous polyps	34	52	24	Mexico	Caucasian	PCR-RFLP	0.625
Giovannucci [21]	2003	6	rs1801133	157	168	49	adenomatous polyps	299	325	101	USA	Caucasian	PCR-RFLP	0.401
Giovannucci [21]			rs1801131	186	165	24	adenomatous polyps	369	299	57	USA	Caucasian	PCR-RFLP	0.740
Goode [22]	2004	7	rs1801133	236	196	58	adenomatous polyps	259	238	67	USA	Caucasian	PCR-RFLP	0.281
Hazra [23]	2007	7	rs1801133	217	245	63	adenomatous polyps	229	232	64	USA	Caucasian	NA	0.658
Hazra [23]			rs1801131	278	211	48	adenomatous polyps	264	219	46	USA	Caucasian	NA	0.951
Hirose [24]	2005	8	rs1801133	182	203	67	adenomatous polyps	399	496	155	Japan	Asian	PCR-RFLP	0.966
Yi [8]	2006	6	rs1801133	5	5	4	adenomatous polyps	2	4	0	Korea	Asian	PCR-RFLP	0.221
Yi [8]			rs1801131	10	3	1	adenomatous polyps	3	3	0	Korea	Asian	PCR-RFLP	0.414
Levine [25]	2000	7	rs1801133	256	163	52	adenomatous polyps	263	198	49	USA	Caucasian	PCR-RFLP	0.193
Lightfoot [26]	2008	8	rs1801133	135	132	41	adenomatous polyps	130	139	27	UK	Caucasian	Taqman drug metabolizing genotyping assays	0.238
Lightfoot [26]			rs1801131	155	124	29	adenomatous polyps	140	130	26	UK	Caucasian	Taqman drug metabolizing genotyping assays	0.590
Marugame [10]	2000	8	rs1801133	83	92	30	adenomatous polyps	89	105	26	Japan	Asian	PCR-RFLP	0.555
Mitrou [27]	2006	7	rs1801133	405	376	87	adenomatous polyps	402	407	89	UK	Caucasian	PCR-RFLP	0.340
			rs1801131	383	375	104	adenomatous polyps	415	380	88	UK	Caucasian	PCR-RFLP	0.941
Pufulete [28]	2003	7	rs1801133	20	13	2	adenomatous polyps	41	29	6	UK	Caucasian	PCR-RFLP	0.784
Pufulete [28]			rs1801131	18	12	5	adenomatous polyps	47	26	3	UK	Caucasian	PCR-RFLP	0.799
Ulrich [29]	1999	9	rs1801133	258	219	50	adenomatous polyps	303	269	73	USA	Caucasian	PCR-RFLP	0.260
Ulrich [30]	2000	7	rs1801133	98	72	26	hyperplastic polyps	297	258	71	USA	Caucasian	PCR-RFLP	0.192
van den [9]	2005	7	rs1801133	343	346	79	adenomatous polyps	325	305	79	Netherlands	Caucasian	PCR-RFLP	0.560
Williams [31]	2013	7	rs1801133	34	48	8	adenomatous polyps	44	42	9	UK	Caucasian	PCR-RFLP	0.822
Yamaji [32]	2009	6	rs1801133	263	325	124	adenomatous polyps	219	324	120	Japan	Asian	TaqMan PCR	0.993
Yamaji [32]			rs1801131	452	228	32	adenomatous polyps	441	197	25	Japan	Asian	TaqMan PCR	0.609

A/A C/C genotype of rs1801133, or A/A genotype of rs1801131, A/B C/T genotype of rs1801133, or A/C genotype of rs1801131, B/B T/T genotype of rs1801133, or C/C genotype of rs1801131, NA not available, PCR-RFLP polymerase chain reaction-restriction fragment length polymorphism, HWE Hardy-Weinberg Equilibrium, NOS Newcastle-Ottawa Scale

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ISSN: 1471-2350

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