Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts

Table 5 Minor allele counts for rare putative regulatory variants, odds ratios and p-values from Fisher’s exact test for genes of interest

Gene of interest	Allele Counts (# Reg. Variants) ISKS^a	Allele Counts (#Reg. Variants) MGRB^b	Odds ratio	p-value^c	Q-value ^d
ABCB5	12 (5)	3 (3)	4.9	0.007	0.049
ARHGAP39	10 (3)	24 (4)	1.13	0.702	1.00
BEAN1	3 (1)	1 (1)	6.11	0.10	0.800
C16orf96	58 (3)	151 (3)	0.58	0.0004	0.003
KIF2C	2 (1)	9 (1)	0.45	0.52	1.00
PDIA2	10 (1)	24 (1)	0.85	0.85	1.00
UVSSA	114 (4)	215 (4)	1.09	0.44	1.00
ZFP69B	0 (0)	0 (0)	–	–	–

^aISKS International Sarcoma Kindred Study. ^bMGRB Medical Genome Reference Bank. ^cUncorrected p-value. ^dBonferroni corrected p-value for multiple testing (α = 0.05)

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