Intronic polymorphisms in genes LRFN2 (rs2494938) and DNAH11 (rs2285947) are prognostic indicators of esophageal squamous cell carcinoma

Table 2 Genotyping results with ESCC patients’ survival

SNPs	Patients^a	Deaths^a	Genetic models	Univariate analysis		Multivariate analysis
SNPs	Patients^a	Deaths^a	Genetic models	HR (95% CI)	P	HR (95% CI)^e	P ^e
rs2494938	163/112/12	48/27/7	Additive^b	1.12 (0.76–1.64)	0.566	1.14 (0.78–1.67)	0.509
			Dominant^c	0.92 (0.59–1.43)	0.705	0.94 (0.60–1.46)	0.776
			Recessive^d	3.10 (1.42–6.75)	0.004	3.12 (1.43–6.83)	0.004
rs2285947	145/119/23	33/38/10	Additive^b	1.48 (1.07–2.04)	0.018	1.45 (1.05–2.01)	0.025
			Dominant^c	1.60 (1.03–2.48)	0.038	1.59 (1.02–2.49)	0.042
			Recessive^d	1.77 (0.91–3.43)	0.092	1.68 (0.85–3.31)	0.135
rs2399395	242/43/2	69/12/1	Additive^b	1.06 (0.61–1.85)	0.841	0.95 (0.54–1.66)	0.851
			Dominant^c	1.00 (0.56–1.82)	0.989	0.90 (0.50–1.65)	0.736
			Recessive^d	2.85 (0.40–20.48)	0.299	1.90 (0.26–14.01)	0.530

Abbreviations: CI confidence interval, HR hazard ratio
Values in bold indicate they are statistically different (P < 0.05)
^aWild homozygous type / Heterozygote / Variant homozygous type
^bRare homozygote versus heterozygote versus major homozygote
^cHeterozygote/rare homozygote versus major homozygote
^dRare homozygote versus heterozygote/major homozygote
^eAdjusted for age, gender, tumor site, TNM stage, tumor differentiation, smoking and drinking status in Cox regression model

ISSN: 1471-2350