Table 2 Comparison of two groups of Chechen CF patients
Group 1 (n = 17) | Group 2 (n = 8) | |||
|---|---|---|---|---|
CFTR genotype | c.[1545_1546delTA];[1545_1546delTA] (p.[Tyr515X];[Tyr515X]); (1677delTA/1677delTA) | c.[1545_1546delTA];[274G > A] (p.[Tyr515X];[Glu92Lys]); (1677delTA/E92K) | p-value | |
Age at last clinical examination (yrs) | 5.66 ± 8.28 (0.29÷31.46) | 4.53 ± 4.13 (0.92÷11.92) | > 0.05 | |
Age at diagnosis (yrs) | 1.66 ± 0.91 (0.00÷20.18) | 1.07 ± 0.91 (0.16÷3.00) | > 0.05 | |
BMI (kg/m2) | 14.93 ± 3.12 (12.30÷24.88) | 15.92 ± 2.55 (13.00÷21.00) | > 0.05 | |
Sweat chloride (mM/L) | 120.25 ± 36.27 (100.00÷134.00) | 120.25 ± 15.62 (100.00÷134.00) | > 0.05 | |
FEV1 (% predicted) | 82.66 ± 26.85 (52.00÷102.00) | 91.50 ± 2.12 (90.00÷93.00) | > 0.05 | |
FVC (% predicted) | 93.66 ± 27.09 (68.00÷122.00) | 91.50 ± 2.12 ((90.00÷93.00) | > 0.05 | |
Meconium ileus | 0 | 0 | ||
Liver cirrhosis | 0 | 0 | ||
CF-related diabetes mellitus | 0 | 0 | ||
Fecal elastase 1 concentration | ≥200 μg/g | 0 | 8 | < 0.0001 |
< 200 μg/g | 17 | 0 | ||
S. aureus lung colonization | 44% | 14% | > 0.05 | |
P. aeruginosa lung colonization | 69% | 14% | 0.024 | |