A pharmacogenetic study of patients with schizophrenia from West Siberia gets insight into dopaminergic mechanisms of antipsychotic-induced hyperprolactinemia

Table 4 Analysis of association between HPRL and the polymorphisms of MAO genes for all patients divided by gender

Gender	SNP	OR	95% CI Lower bound	95% CI Upper bound	p-value
Females	rs1799836	0.939	0.644	1.369	0.744
	rs1137070	0.757	0.497	1.153	0.195
	rs6323	0.786	0.512	1.208	0.273
Males	rs1799836	0.748	0.561	0.998	0.048*
	rs1137070	1.279	0.942	1.737	0.115
	rs6323	1.315	0.970	1.782	0.078

Logistic regression analysis was used to test additive genetic model for association between HPRL and the MAO genes polymorphisms in males and females separately adjusting for age and CPZeq. OR – odds ratio; CI – lower and upper bound 95% confidence intervals. ORs are reported for the risk of HPRL attributable to the rare allele vs common allele
*Values are deemed to have significance

ISSN: 1471-2350