Analysis of genetic polymorphisms for age-related macular degeneration (AMD) in Chinese Tujia ethnic minority group

Liu, Shengchun; Wu, Mingxing; Zhang, Bianwen; Xiong, Xiaojing; Wang, Hao; Zhou, Xiyuan

doi:10.1186/s12881-019-0756-4

Table 2 Genotype and allele frequencies of ten genes’ polymorphism in AMD and healthy controls

From: Analysis of genetic polymorphisms for age-related macular degeneration (AMD) in Chinese Tujia ethnic minority group

Genes	SNPs		Case	Control	HWE	P	Pc	OR	95%Cl
CFH	rs1329428	Total sample	197	404
		CC	59	136	0.175	0.361	NS	0.842	0.583–1.217
		CT	94	208		0.386	NS	0.860	0.612–1.209
		TT	44	60		0.023	NS	1.649	1.069–2.543
		C	212	480
		T	182	328		0.065	NS	0.796	0.624–1.015
CFH	rs3753394	Total sample	197	403
		CC	55	74	0.416	0.006	NS	1.738	1.164–2.594
		CT	89	208		0.163	NS	0.784	0.558–1.104
		TT	53	124		0.357	NS	0.837	0.573–1.223
		C	199	356
		T	195	456		0.029	NS	1.307	1.027–1.664
CFH	rs1410996	Total sample	190	386
		GG	60	137	0.128	0.469	NS	0.873	0.603–1.262
		GA	87	204		0.194	NS	0.795	0.562–1.125
		AA	43	55		0.008	NS	1.814	1.164–2.826
		G	207	478
		A	173	314		0.056	NS	0.786	0.614–1.006
CFH	rs800292	Total sample	193	402
		GG	54	140	0.190	0.095	NS	0.727	0.500–1.058
		GA	95	205		0.686	NS	0.932	0.661–1.313
		AA	44	57		0.009	NS	1.787	1.154–2.769
		G	203	485
		A	183	319		0.011	NS	0.730	0.571–0.932
VEGF	rs833061	Total sample	192	403
		TT	113	196	0.881	0.020	NS	1.511	1.067–2.138
		TC	67	171		0.079	NS	0.727	0.509–1.039
		CC	12	36		0.261	NS	0.680	0.345–1.338
		T	293	563
		C	91	243		0.021	NS	1.390	1.051–1.837
VEGF	rs2010963	Total sample	189	396
		CC	27	64	0.089	0.558	NS	0.865	0.531–1.408
		CG	99	170		0.032	NS	1.462	1.033–2.071
		GG	63	162		0.078	NS	0.722	0.502–1.038
		C	153	298
		G	225	494		0.349	NS	1.127	0.877–1.448
VEGFR2	rs1531289	Total sample	197	404
		CC	118	275	0.181	0.048	NS	0.701	0.492–0.998
		CT	62	111		0.310	NS	1.212	0.836–1.758
		TT	17	18		0.040	NS	2.025	1.020–4.022
		C	298	661
		T	96	147		0.012	NS	0.690	0.516–0.924
ARMS2	rs10490924	Total sample	197	404
		GG	57	137	0.625	0.213	NS	0.791	0.546–1.145
		GT	86	200		0.169	NS	0.786	0.558–1.108
		TT	54	66		0.002	NS	1.928	1.280–2.904
		G	200	474
		T	194	332		0.008	NS	0.722	0.567–0.920
KCTD10/MVK	rs2338104	Total sample	197	403
		GG	19	44	0.673	0.633	NS	0.871	0.494–1.536
		GC	110	184		0.019	NS	1.505	1.068–2.120
		CC	68	175		0.037	NS	0.687	0.482–0.978
		G	148	272
		C	246	534		0.193	NS	1.181	0.919–1.518
CX3CR1	rs3732378	Total sample	193	402
		AA	3	0	0.573	0.034	NS
		AG	12	22		0.714	NS	1.145	0.554–2.365
		GG	178	380		0.277	NS	0.687	0.348–1.356
		A	18	22
		G	368	782		0.084	NS	1.739	0.921–3.281

Back to article page

ISSN: 1471-2350

Contact us

General enquiries: ORSupport@springernature.com

BMC Medical Genetics

Contact us