The role of MMP-12 gene polymorphism − 82 A-to-G (rs2276109) in immunopathology of COPD in polish patients: a case control study

Table 2 MMP-12 gene polymorphism -82 A-to-G impact on lung function of COPD patients and healthy control groups

Genotypes MMP-12-82A > G	COPD patients			CTR			CTR smokers			CTR non-smokers
	N = 355			N = 309			N = 110			N = 199
	N	FEV₁ (% predict.)	FEV₁/FVC (% predict.)	N	FEV₁ (% predict.)	FEV₁/FVC (% predict.)	N	FEV₁ (% predict.)	FEV₁/FVC (% predict.)	N	FEV₁ (% predict.)	FEV₁/FVC (% predict.)
A allele	333	55.5 ± 18.6	52.3 ± 16.0	297	92.0 ± 23.4	86.2 ± 23.2	105	92.8 ± 21.8	92.0 ± 19.5	192	91.5 ± 23.3	85.8 ± 24.5
G allele	82	54.1 ± 15.8	51.4 ± 17.9	93	92.1 ± 20.7	92.8 ± 24.7	14	94.9 ± 21.9	90.7 ± 20.6	49	88.5 ± 20.4	95.8 ± 27.8
AA	253	55.9 ± 19.3	52.5 ± 15.4	216	92.0 ± 23.4	86.2 ± 23.2	66	92.0 ± 22.2	92.8 ± 18.5	150	91.8 ± 24.2	85.3 ± 26.5
AG	80	53.9 ± 18.0	51.7 ± 18.1	81	92.6 ± 20.1	91.9 ± 21.7	39	94.0 ± 21.4	91.5 ± 21.2	42	90.0 ± 19.9	93.4 ± 22.3
GG	2	56.7 ± 17.4	44.9 ± 18.5	12	88.5 ± 25.3	99.2 ± 40.2	5	101.0 ± 22.6	84.3 ± 15.9	7	79.7 ± 22.3	109.9 ± 47.8
P value*		0.71	0.90		0.95	0.10		0.75	0.26		0.30	0.77

N number of individuals/alleles/genotypes, COPD chronic obstructive pulmonary disease groups, CTR control group, FEV₁ forced expiratory volume in 1 s, FEV₁/FVC Tiffeneau-Pinelli index – ratio of forced expiratory volume in 1 s and forced vital capacity; *, no significant difference in mean of lung function parameters between carriers with different −82 A > G alleles/genotypes in one-way ANOVA test, Tuckey post-hoc test were not conducted

ISSN: 1471-2350