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Table 4 Subgroup analysis of the GSTP1 rs1695 A/G polymorphism by SCC type

From: Glutathione S-transferase pi 1 variant and squamous cell carcinoma susceptibility: a meta-analysis of 52 case-control studies

Subgroup Index Allele Carrier Homozygote Heterozygote Dominant Recessive
ESCC OR (95% CIs) 1.05 (0.96~1.15) 1.03 (0.93~1.14) 1.15 (0.95~1.39) 1.00 (0.88~1.14) 1.03 (0.92~1.17) 1.13 (0.95~1.34)
  P a 0.263 0.568 0.155 0.970 0.575 0.160
  Case/control 1934/3951 1934/3951 1934/3951 1934/3951 1934/3951 1934/3951
  Study number 15 15 15 15 15 15
HNSCC OR (95% CIs) 0.95 (0.89~1.01) 0.96 (0.89~1.03) 0.94 (0.82~1.09) 0.94 (0.87~1.02) 0.93 (0.86~1.01) 0.95 (0.83~1.09)
  P a 0.112 0.247 0.408 0.131 0.102 0.459
  Case/control 4671/4961 4671/4961 4671/4961 4671/4961 4671/4961 4671/4961
  Study number 18 18 18 18 18 18
LSCC OR (95% CIs) 1.00 (0.93~1.08) 1.00 (0.92~1.09) 1.04 (0.88~1.24) 0.97 (0.87~1.07) 0.98 (0.89~1.09) 1.06 (0.90~1.25)
  P a 0.940 0.973 0.616 0.526 0.741 0.485
  Case/control 2574/5421 2574/5421 2574/5421 2574/5421 2574/5421 2574/5421
  Study number 15 15 15 15 15 15
SSCC OR (95% CIs) 0.91 (0.70~1.19) 0.94 (0.69~1.28) 0.83 (0.46~1.49) 0.94 (0.64~1.36) 0.91 (0.64~1.30) 0.86 (0.49~1.51)
  P a 0.493 0.688 0.532 0.728 0.605 0.597
  Case/control 177/475 177/475 177/475 177/475 177/475 177/475
  Study number 3 3 3 3 3 3
  1. ESCC oesophageal squamous cell carcinoma, HNSCC head and neck squamous cell carcinoma, LSCC lung squamous cell carcinoma, SSCC skin squamous cell carcinoma, OR odds ratio, CIs confidence intervals, Pa, P value of association test