Glutathione S-transferase pi 1 variant and squamous cell carcinoma susceptibility: a meta-analysis of 52 case-control studies

Table 4 Subgroup analysis of the GSTP1 rs1695 A/G polymorphism by SCC type

Subgroup	Index	Allele	Carrier	Homozygote	Heterozygote	Dominant	Recessive
ESCC	OR (95% CIs)	1.05 (0.96~1.15)	1.03 (0.93~1.14)	1.15 (0.95~1.39)	1.00 (0.88~1.14)	1.03 (0.92~1.17)	1.13 (0.95~1.34)
	P _a	0.263	0.568	0.155	0.970	0.575	0.160
	Case/control	1934/3951	1934/3951	1934/3951	1934/3951	1934/3951	1934/3951
	Study number	15	15	15	15	15	15
HNSCC	OR (95% CIs)	0.95 (0.89~1.01)	0.96 (0.89~1.03)	0.94 (0.82~1.09)	0.94 (0.87~1.02)	0.93 (0.86~1.01)	0.95 (0.83~1.09)
	P _a	0.112	0.247	0.408	0.131	0.102	0.459
	Case/control	4671/4961	4671/4961	4671/4961	4671/4961	4671/4961	4671/4961
	Study number	18	18	18	18	18	18
LSCC	OR (95% CIs)	1.00 (0.93~1.08)	1.00 (0.92~1.09)	1.04 (0.88~1.24)	0.97 (0.87~1.07)	0.98 (0.89~1.09)	1.06 (0.90~1.25)
	P _a	0.940	0.973	0.616	0.526	0.741	0.485
	Case/control	2574/5421	2574/5421	2574/5421	2574/5421	2574/5421	2574/5421
	Study number	15	15	15	15	15	15
SSCC	OR (95% CIs)	0.91 (0.70~1.19)	0.94 (0.69~1.28)	0.83 (0.46~1.49)	0.94 (0.64~1.36)	0.91 (0.64~1.30)	0.86 (0.49~1.51)
	P _a	0.493	0.688	0.532	0.728	0.605	0.597
	Case/control	177/475	177/475	177/475	177/475	177/475	177/475
	Study number	3	3	3	3	3	3

ESCC oesophageal squamous cell carcinoma, HNSCC head and neck squamous cell carcinoma, LSCC lung squamous cell carcinoma, SSCC skin squamous cell carcinoma, OR odds ratio, CIs confidence intervals, P_a, P value of association test

ISSN: 1471-2350