Glutathione S-transferase pi 1 variant and squamous cell carcinoma susceptibility: a meta-analysis of 52 case-control studies

Wang, Shuang; Zhang, Jingqi; Jun, Fan; Bai, Zhijie

doi:10.1186/s12881-019-0750-x

Table 1 Basic information of the eligible articles in the meta-analysis

From: Glutathione S-transferase pi 1 variant and squamous cell carcinoma susceptibility: a meta-analysis of 52 case-control studies

First author	Year	Region	Race	Assay	Case			Disease type	Control			Control source	P _HWE
First author	Year	Region	Race	Assay	AA	AG	GG	Disease type	AA	AG	GG	Control source	P _HWE
Abbas	2004	France	Caucasian	PCR-RFLP	21	21	3	ESCC	59	56	9	PB	0.38
Cabelguenne	2001	France	Caucasian	PCR-RFLP	89	57	16	HNSCC	146	139	25	HB	0.31
Cai	2006	China	Asian	PCR-RFLP	143	58	3	ESCC	265	116	12	PB	0.87
Cho	2006	Korea	Asian	Gene sequencing	201	85	7	HNSCC	211	112	10	HB	0.29
Dura	2013	Netherlands	Caucasian	PCR	48	42	15	ESCC	246	261	84	PB	0.27
Dzian	2012	Netherlands	Caucasian	PCR-RFLP	56	45	11	LSCC	153	115	22	PB/HB	0.95
Evans	2004	USA	Caucasian	PCR-RFLP	123	132	27	HNSCC	97	85	24	PB	0.42
Fryer	2005	Australia	Caucasian	PCR-RFLP	59	51	18	SSCC	95	90	25	HB	0.60
Harth	2008	Germany	Caucasian	PCR-melting-curve	145	122	45	HNSCC	130	138	32	HB	0.62
Jain	2006	India	Asian	PCR-RFLP	46	23	7	ESCC	72	56	9	HB	0.67
Jourenkova	1999a	France	Caucasian	PCR-RFLP	49	53	15	HNSCC	86	64	22	HB	0.07
Jourenkova	1999b	France	Caucasian	PCR-RFLP	62	52	15	HNSCC	86	64	22	HB	0.07
Jourenkova	1998	France	Caucasian	PCR-RFLP	46	41	11	LSCC	86	64	22	HB	0.07
Kelders	2002	Netherlands	Caucasian	PCR-RFLP	36	38	13	HNSCC	26	18	7	HB	0.20
Kihara	1999	Japan	Asian	PCR-RFLP	84	32	9	LSCC	184	65	8	HB	0.45
Larsen	2006	Australia	Caucasian	PCR-RFLP	230	213	51	LSCC	161	169	49^a	HB	0.66
		Australia	Caucasian	PCR-RFLP	230	213	51	LSCC	112	100	35^b	PB	0.11
Leichsenring	2006	Brazil	Mixed	PCR-RFLP	30	34	8	HNSCC	30	25	5	PB	0.95
Leite	2007	Brazil	Mixed	PCR-RFLP	14	13	2	SSCC	60	46	18	PB	0.07
Lewis	2002	UK	Caucasian	PCR-RFLP	14	17	1	LSCC	64	74	13	HB	0.19
Li	2010	South African	Black African	PCR-RFLP	56	59	26	ESCC	76	83	27	PB	0.58
			Mixed	PCR-RFLP	34	52	11	ESCC	30	51	13	PB	0.24
Li	2007	USA	Caucasian	PCR-RFLP	336	356	111	HNSCC	333	385	121	PB	0.57
Liang	2005	China	Asian	diASA-AMP	58	32	4	LSCC	132	86	9	HB	0.27
Liu	2010	China	Asian	PCR-RFLP	66	29	0	ESCC	61	27	3	PB	1.00
Malik	2010	India	Asian	PCR-RFLP	53	36	14	ESCC	111	75	9	PB	0.41
Matejcic	2011	South African	Black African	TaqMan genotyping	79	155	91	ESCC	100	242	132	PB	0.57
		South African	Mixed	TaqMan genotyping	69	112	48	ESCC	145	191	92	PB	0.05
McWilliams	2000	USA	Mixed	PCR-RFLP	60	73	13	HNSCC	58	51	15	HB	0.47
Miller	2006	USA	Caucasian	PCR-RFLP	190	173	49	LSCC	579	623	141	PB	0.16
Moaven	2010	Iran	Asian	PCR-RFLP	84	50	14	ESCC	74	54	8	PB	0.65
Nazar	2003	USA	Mixed	PCR-RFLP	35	29	9	LSCC	199	234	54	PB	0.23
Olshan	2000	USA	Mixed	PCR-RFLP	40	62	7	HNSCC	68	80	20	HB^c	0.63
		USA	Mixed	PCR-RFLP	18	38	7	HNSCC	7	13	5	HB^d	0.82
Oude	2003	Netherlands	Caucasian	PCR-RFLP	116	90	29	HNSCC	125	121	39	PB	0.27
Peters	2006	USA	Mixed	PCR-RFLP	303	311	76	HNSCC	333	329	86	PB	0.73
Ramsay	2001	UK	Caucasian	SSCP	10	10	0	SSCC	53	71	17	HB	0.36
Risch	2001	Germany	Caucasian	PCR-RFLP	76	77	18	LSCC	167	151	35	HB	0.92
Rossini	2007	Brazil	Mixed	PCR-RFLP	42	65	18	ESCC	116	108	28	PB	0.71
Ruwali	2009	India	Caucasian	PCR-RFLP	224	112	14	HNSCC	199	138	13	PB	0.06
Ruwali	2011	India	Caucasian	PCR-RFLP	316	162	22	HNSCC	285	195	20	PB	0.06
Ryberg	1997	Norway	Caucasian	PCR-RFLP	20	34	13	LSCC	153	117	27	PB	0.50
Schneider	2004	Germany	Caucasian	PCR-melting-curve	81	75	27	LSCC	298	254	70	PB/HB	0.16
Soucek	2010	Czech/Polish	Caucasian	TaqMan drug metabolism genotyping	56	53	7	HNSCC	57	50	10	PB	0.52
Soya	2007	India	Asian	PCR-RFLP	219	162	27	UADTSCC	120	88	12	PB	0.42
Stücker	2002	France	Caucasian	PCR-RFLP	54	46	15	LSCC	124	120	20	HB	0.22
Tan	2000	China	Asian	PCR-RFLP	93	48	9	ESCC	91	53	6	PB	0.62
To	2002	Spain	Caucasian	PCR-RFLP	101	84	19	HNSCC	100	78	23	PB	0.20
To	1999	Spain	Caucasian	PCR-RFLP	29	20	3	LSCC	64	54	14	PB^b	0.61
		Spain	Caucasian	PCR-RFLP	29	20	3	LSCC	90	90	20	PB^e	0.72
van	1999	Netherlands	Caucasian	PCR-RFLP	5	6	2	ESCC	146	89	12	PB	0.74
Zendehdel	2009	Sweden	Caucasian	Pyrosequencing	26	42	10	ESCC	208	207	38	PB	0.18

PCR polymerase chain reaction, PCR-RFLP polymerase chain reaction-restriction fragment length polymorphism, diASA-AMP di-allele-specific-amplification with artificially modified primers assay, SSCP Single-stranded conformational polymorphism, ESCC oesophageal squamous cell carcinoma, HNSCC head and neck squamous cell carcinoma, LSCC lung squamous cell carcinoma, SSCC skin squamous cell carcinoma, OSCC oral squamous cell carcinoma, UADTSCC upper aerodigestive tract squamous cell carcinoma, PB population-based, HB hospital-based, P_HWE P value of hardy-weinberg equilibrium
^aCOPD patients without LSCC, ^bhealthy smokers; ^ccontrol from Caucasian population; ^dcontrol from Black African population; ^econtrol from general population

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ISSN: 1471-2350

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