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Table 2 Reports on AN with or without HCH due to p. Lys650Thr of FGFR3

From: Acanthosis nigricans in a Chinese girl with FGFR3 K650 T mutation: a case report and literature review

Patients Onset age Age Gender AN HCH Birth weight (g) Height (cm) BMI FBG(74-105 mg/dL) FINS (1.5–18.5μU/ml) HOMA-IR HbA1c
Family 3[6]
 1a infancy 4 F + / 105.5 (5.5y,8th) 15.5 normal / / normal
 2 / 25 M + / 156 19.7 / / / /
 3 / 29 F + / 145 (<5th) 30.5 / / / /
 4 / 11 F + / 139 (26th) 21.2 / / / /
Family 1[2]
 5 infancy 51 M + + / 144.3 26.4 190 5.3 2.4 7.9
 6 infancy 49 F + + / 141.2 28.1 81 3.6 0.7 4.4
 7 infancy 46 F + + / 145.5 26.9 92 4.4 0.9 4.9
 8 infancy 40 F + + / 149.4 28.3 87 5.1 1.1 4.8
 9 infancy 35 F + + / 153 25.8 85 3.9 0.8 4.3
 10a infancy 16 M + + 3515 / 24.2 97 7.0 1.6 4.6
 11 infancy 18 F + + / 147.9 26.5 73 2.8 0.5 4.2
 12 infancy 8 M + + / / 20.6 88 3.8 0.8 4.5
 13 infancy 13 M + + / / 20.2 90 6.9 1.5 4.6
 14 infancy 7 M + + / / 23 92 6.1 1.3 4.7
Family 5[1]
 15a 3 15 F + / / / / / / /
 16 / / F + / / / / / / /
 17 / / F + / / / / / / /
Family 2[3]
 18a 12 14 M + + / 143 21.5 / / / /
 19 / / M + + / / / / / / /
 20 / / M + + / / / / / / /
 21 / / M + + / / / / / / /
Family 4[4]
 22a 1 3 M + + 2883 91.7 (3-10th) 19.4 76 8.8 1.6  
Family 6[5]
 23a 2 10 M + + / 128 23.1 / 3.1 / /
 24 / 12 F + + / 135 23.5 / / / /
 25 / 47 M + + / 155 25 / / / /
 26 / 74 F + + / 140 23 / / / /
Current case
 27a 4 17 F + 4000 146 24.4 88.2 13.78 3.0 5.1
  1. aProband of the family
  2. AN acanthosis nigricans, HCH hypochondroplasia, BMI body mass index, FBG fasting glucose, FINS fasting insulin, HOMA-IR homeostasis model assessment index of insulin resistance, HbA1c glycosylated hemoglobin