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Fig. 8 | BMC Medical Genetics

Fig. 8

From: Modeling gene-environment interactions in longitudinal family studies: a comparison of methods and their application to the association between the IGF pathway and childhood obesity

Fig. 8

Significance of interactions between the IGF pathway genes and environmental factors. Negative natural log transformed p-values from the twin model, the linear mixed model and the PBI test were compared with unadjusted significance level (ɑ = 0.05) and Bonferroni-adjusted level (ɑadj = 0.006). Genetic (IGF-1, IGFALS) and environmental (physical activities, daycare attendance, sleep duration) main effects were evaluated by the twin and linear mixed models. All methods estimated significance of gene-environment interaction effects. Any effect with significance per unadjusted level (p-value < 0.05) is labeled for the involved IGF-1 or IGFALS SNP. LMM = linear mixed model; PBI = partition based score I test

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BMC Medical Genetics

ISSN: 1471-2350

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